Novel Aspects of the Renal Renin-Angiotensin System: Angiotensin-(1-7),ACE2 and Blood Pressure Regulation

2004 ◽  
pp. 77-89 ◽  
Author(s):  
M.C. Chappell ◽  
J.G. Modrall ◽  
D.I. Diz ◽  
C.M. Ferrario
Keyword(s):  
Blood Pressure ◽  
Renin Angiotensin System ◽  
Blood Pressure Regulation ◽  
Pressure Regulation ◽  
Angiotensin System ◽  
Renin Angiotensin

Role of the Brain Renin-angiotensin System in Blood Pressure Regulation

2007 ◽  
Vol 31 (S1) ◽  
pp. 343-346
Author(s):  
M. V. Varoni ◽  
D. Palomba ◽  
M. P. Demontis ◽  
S. Gianorso ◽  
G. L. Pais ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renin Angiotensin System ◽  
Blood Pressure Regulation ◽  
Pressure Regulation ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
The Brain

Role of renin-angiotensin system in blood pressure regulation in pregnancy

The Lancet ◽  
1995 ◽  
Vol 345 (8954) ◽  
pp. 896-897 ◽  
Author(s):  
P. August ◽  
F.B. Mueller ◽  
J.E. Sealey ◽  
T.G. Edersheim
Keyword(s):  
Blood Pressure ◽  
Renin Angiotensin System ◽  
Blood Pressure Regulation ◽  
Pressure Regulation ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
In Pregnancy

The depressor axis of the renin–angiotensin system and brain disorders: a translational approach

2018 ◽  
Vol 132 (10) ◽  
pp. 1021-1038 ◽  
Author(s):  
Mariela M. Gironacci ◽  
Augusto Vicario ◽  
Gustavo Cerezo ◽  
Mauro G. Silva
Keyword(s):  
Blood Pressure ◽  
Angiotensin Converting Enzyme ◽  
Renin Angiotensin System ◽  
Blood Pressure Regulation ◽  
Brain Disorders ◽  
Pressure Regulation ◽  
Converting Enzyme ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Brain Functions

All the components of the classic renin–angiotensin system (RAS) have been identified in the brain. Today, the RAS is considered to be composed mainly of two axes: the pressor axis, represented by angiotensin (Ang) II/angiotensin-converting enzyme/AT1 receptors, and the depressor and protective one, represented by Ang-(1–7)/ angiotensin-converting enzyme 2/Mas receptors. Although the RAS exerts a pivotal role on electrolyte homeostasis and blood pressure regulation, their components are also implicated in higher brain functions, including cognition, memory, anxiety and depression, and several neurological disorders. Overactivity of the pressor axis of the RAS has been implicated in stroke and several brain disorders, such as cognitive impairment, dementia, and Alzheimer or Parkinson’s disease. The present review is focused on the role of the protective axis of the RAS in brain disorders beyond its effects on blood pressure regulation. Furthermore, the use of drugs targeting centrally RAS and its beneficial effects on brain disorders are also discussed.

Sign in / Sign up

Export Citation Format

Share Document