Alzheimer�s γ-Secretase Mechanism Produces Amyloid-β-Protein Like Peptides Simultaneously with Release of Intracellular Signaling Fragments

2004 ◽  
pp. 31-41
Author(s):  
M. Okochi ◽  
A. Fukumori ◽  
Y. Satoh ◽  
N. Aidaralieva ◽  
H. Tanii ◽  
...  
Keyword(s):  
Amyloid Beta ◽  
Intracellular Signaling ◽  
Gamma Secretase ◽  
Amyloid Beta Protein

Proteolytic processing of the amyloid-beta protein precursor of Alzheimer's disease

2002 ◽  
Vol 38 ◽  
pp. 37-49 ◽  
Author(s):  
Janelle Nunan ◽  
David H Small
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Alternative Pathway ◽  
Protein A ◽  
Proteolytic Processing ◽  
Gamma Secretase ◽  
Amyloid Beta Protein ◽  
Protein Precursor ◽  
Amyloid Beta Protein Precursor

The proteolytic processing of the amyloid-beta protein precursor plays a key role in the development of Alzheimer's disease. Cleavage of the amyloid-beta protein precursor may occur via two pathways, both of which involve the action of proteases called secretases. One pathway, involving beta- and gamma-secretase, liberates amyloid-beta protein, a protein associated with the neurodegeneration seen in Alzheimer's disease. The alternative pathway, involving alpha-secretase, precludes amyloid-beta protein formation. In this review, we describe the progress that has been made in identifying the secretases and their potential as therapeutic targets in the treatment or prevention of Alzheimer's disease.

scholarly journals Thrombin receptor activation induces secretion and nonamyloidogenic processing of amyloid beta-protein precursor.

1994 ◽  
Vol 269 (36) ◽  
pp. 22623-22627 ◽  
Author(s):  
J. Davis-Salinas ◽  
S.M. Saporito-Irwin ◽  
F.M. Donovan ◽  
D.D. Cunningham ◽  
W.E. Van Nostrand
Keyword(s):  
Amyloid Beta ◽  
Receptor Activation ◽  
Thrombin Receptor ◽  
Amyloid Beta Protein ◽  
Protein Precursor ◽  
Amyloid Beta Protein Precursor

IMMUNOREACTIVITY OF NEURONAL LIPOFUSCIN WITH MONOCLONAL ANTIBODIES TO THE AMYLOID BETA PROTEIN

1988 ◽  
Vol 2 (3) ◽  
pp. 262 ◽  
Author(s):  
C. BANCHER ◽  
I. GRU NDKE-IQBAL ◽  
K. IQBAL ◽  
K. S. KIM ◽  
H. M. WISNIEWSKI
Keyword(s):  
Monoclonal Antibodies ◽  
Amyloid Beta ◽  
Amyloid Beta Protein

The beta APP717 Alzheimer mutation increases the percentage of plasma amyloid-beta protein ending at A beta 42(43)

Neurology ◽  
1997 ◽  
Vol 48 (3) ◽  
pp. 741-745 ◽  
Author(s):  
T. Kosaka ◽  
M. Imagawa ◽  
K. Seki ◽  
H. Arai ◽  
H. Sasaki ◽  
...  
Keyword(s):  
Amyloid Beta ◽  
Amyloid Beta Protein
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