Background and Initial Preclinical Results with a Novel Second-Generation Blood Substitute

A second-generation blood substitute (perfluorodichlorooctane emulsion) does not activate complement during an ex vivo circulation model of bypass

Journal of Cardiothoracic and Vascular Anesthesia ◽

10.1016/s1053-0770(98)90191-4 ◽

1998 ◽

Vol 12 (4) ◽

pp. 397-401 ◽

Cited By ~ 8

Author(s):

John D. Rosoff ◽

Louise O. Soltow ◽

Craig R. Vocelka ◽

Gottfried Schmer ◽

Wayne L. Chandler ◽

...

Keyword(s):

Second Generation ◽

Ex Vivo ◽

Circulation Model ◽

Blood Substitute

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A Second-Generation Blood Substitute (Perfluorodichlorooctane Emulsion) Generates Spurious Elevations in Platelet Counts from Automated Hematology Analyzers

Anesthesia & Analgesia ◽

10.1097/00000539-200003000-00004 ◽

2000 ◽

Vol 90 (3) ◽

pp. 517-522 ◽

Cited By ~ 13

Author(s):

Olivier Y. Cuignet ◽

Brent L. Wood ◽

Wayne L. Chandler ◽

Bruce D. Spiess

Keyword(s):

Second Generation ◽

Blood Substitute ◽

Platelet Counts ◽

Hematology Analyzers

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A Second-Generation Blood Substitute (Perflubron Emulsion) Increases the Blood Solubility of Modern Volatile Anesthetics In Vitro

Anesthesia & Analgesia ◽

10.1213/00000539-200208000-00023 ◽

2002 ◽

Vol 95 (2) ◽

pp. 368-372

Author(s):

Olivier Y. Cuignet ◽

Philippe M. Baele ◽

Luc J. Van Obbergh

Keyword(s):

Second Generation ◽

Blood Substitute ◽

Volatile Anesthetics ◽

Blood Solubility

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A Second-Generation Blood Substitute (Perflubron Emulsion) Increases the Blood Solubility of Modern Volatile Anesthetics In Vitro

Anesthesia & Analgesia ◽

10.1097/00000539-200208000-00023 ◽

2002 ◽

Vol 95 (2) ◽

pp. 368-372 ◽

Cited By ~ 3

Author(s):

Olivier Y. Cuignet ◽

Philippe M. Baele ◽

Luc J. Van Obbergh

Keyword(s):

Second Generation ◽

Blood Substitute ◽

Volatile Anesthetics ◽

Blood Solubility

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Sinusoidal Cells in Bone Marrow Take Up BSA-Au Conjugates in the Presence of an Artificial Blood Substitute

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100120199 ◽

1985 ◽

Vol 43 ◽

pp. 700-701

Author(s):

J.S. Geoffroy ◽

R.P. Becker

Keyword(s):

Bone Marrow ◽

Los Angeles ◽

Iliac Artery ◽

Blood Substitute ◽

Sprague Dawley ◽

Coated Pits ◽

Sinusoidal Cells ◽

Artificial Blood ◽

Left Common Iliac Artery

The pattern of BSA-Au uptake in vivo by endothelial cells of the venous sinuses (sinusoidal cells) of rat bone marrow has been described previously. BSA-Au conjugates are taken up exclusively in coated pits and vesicles, enter and pass through an “endosomal” compartment comprised of smooth-membraned tubules and vacuoles and cup-like bodies, and subsequently reside in multivesicular and dense bodies. The process is very rapid, with BSA-Au reaching secondary lysosmes one minute after presentation. (Figure 1)In further investigations of this process an isolated limb perfusion method using an artificial blood substitute, Oxypherol-ET (O-ET; Alpha Therapeutics, Los Angeles, CA) was developed. Under nembutal anesthesia, male Sprague-Dawley rats were laparotomized. The left common iliac artery and vein were ligated and the right iliac artery was cannulated via the aorta with a small vein catheter. Pump tubing, preprimed with oxygenated 0-ET at 37°C, was connected to the cannula.

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