Increasing Incidence of Critical Liver Disease among Causes of Death in Japanese Hemophiliacs with HIV-1

2004 ◽  
Vol 111 (4) ◽  
pp. 181-184 ◽  
Author(s):  
Shinobu Tatsunami ◽  
Masashi Taki ◽  
Akira Shirahata ◽  
Junichi Mimaya ◽  
Kaneo Yamada
Keyword(s):  
Liver Disease ◽  
Causes Of Death ◽  
Hiv 1

scholarly journals Circulating miR-122 and miR-200a as biomarkers for fatal liver disease in ART-treated, HIV-1-infected individuals

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Daniel D. Murray ◽  
Kazuo Suzuki ◽  
Matthew Law ◽  
Jonel Trebicka ◽  
Jacquie Neuhaus Nordwall ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatal Liver ◽  
Hiv 1

scholarly journals HAART and Causes of Death in Perinatally HIV-1-Infected Children

10.5772/32695 ◽  
2011 ◽  
Author(s):  
Claudia Palladino ◽  
Jose Maria ◽  
Francisco J. ◽  
Maria del Palacio Tamarit ◽  
Isabel de ◽  
...  
Keyword(s):  
Causes Of Death ◽  
Hiv 1

scholarly journals Comorbidity Risk Factors Contributing to COVID-19 Related Deaths in Florida, March 1, 2020-January 16, 2021

2021 ◽  
Author(s):  
Ursula K Weiss ◽  
Jason D Maynard ◽  
Katherine McDaniel ◽  
Alyssa Cohen ◽  
Marie Bailey ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Down Syndrome ◽  
Heart Disease ◽  
Liver Disease ◽  
Kidney Disease ◽  
Chronic Liver Disease ◽  
Causes Of Death ◽  
Chronic Liver ◽  
Comorbid Conditions

Abstract Objectives To assess the association of specific comorbid conditions to COVID-19 deaths in Florida among decedents 16 to 64 years of age. Methods This report uses Florida vital statistics death data over the period of March 1, 2020 through January 16, 2021, to estimate the effects of comorbid conditions on COVID-19 mortality for decedents 16 to 64 years of age. All cases of COVID-19 death occurring in Florida, regardless of resident status, were evaluated. The comorbidities, or contributing causes of death, identified in this report include Down syndrome, asthma, diabetes, pulmonary fibrosis, obesity, dementia, immunodeficiency, kidney disease, chronic obstructive pulmonary disease, hypertension, heart disease, and chronic liver disease and cirrhosis. The study uses a binary logistic regression to examine the relationship between COVID-19 and non-COVID-19 death and contributing causes of death based on information in the death record. Odds ratios were calculated as a residual of the logistic regression. Results Among COVID-19 deaths, Down syndrome was 15.26 times more likely to be a contributing cause of death compared to non-COVID-19 deaths followed by asthma (OR 7.74), diabetes (OR 6.11), pulmonary fibrosis (OR 5.13), obesity (OR 4.66), dementia (OR 4.51), immunodeficiency (OR 2.49), and kidney disease (OR 2.13). Chronic liver disease and cirrhosis (OR 0.95) and cancer (OR 0.79) had lower odds of being a contributing cause of death. Conclusions Heart disease, chronic liver disease and cirrhosis, and cancer were not risk factors for death from COVID-19 among decedents. Additional studies are needed to elucidate associations between race/ethnicity, socioeconomic status, and behavioral factors.

Survival of HIV Infected Individuals with Hemophilia after 20 Years: From the Canadian Hemophilia Registry.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 3085-3085
Author(s):  
Irwin R. Walker ◽  
Donald M. Arnold ◽  
Jim A. Julian
Keyword(s):  
Liver Disease ◽  
Liver Failure ◽  
Cause Of Death ◽  
Death Rate ◽  
Causes Of Death ◽  
Current Status ◽  
Annual Number ◽  
Hiv Positive ◽  
Overall Mortality

Abstract Background : Patients with hemophilia A and B have been tracked by the Canadian Hemophilia Registry since 1980. The total number on the Registry is 3307 (A=2721, B=586) of which 662 were/are HIV-positive. New HIV and HCV infections ceased after 1985 and 1988 respectively with the introduction of safer blood products; HIV-infected individuals with hemophilia therefore resemble a cohort with HIV infection that was acquired in a relatively narrow time period about 20 years ago. Current status of HIV-positive patients is Active 250 (37.8%), Deceased 406 (61.3%), Lost to Follow Up 9 (0.9%). Follow up data is available for 3135/3307 (95% of all patients), and for 656/662 (99% of HIV-positive patients). We previously reported (Haemophilia1998;4:714) a peak in the death rate of HIV-positive individuals during the years 1991 to 1993 with a subsequent decline. Objective : To update the rate and causes of death among HIV positive hemophilia patients in Canada with current information. HIV-Related Mortality : The annual number of deaths in the HIV-positive group has been [year-#(deaths per 100 person-years)], 1980-0(0), 81-0(0),82-0(0),83-3(0.45),84-1(0.15),85-2(0.30),86-12(1.8),87-12(1.9),88-21(3.3),89-25(4.1),90-24(4.1),91-45(8.0),92-38(7.4),93-Currently, 256/662 (38.7%) are alive. Causes of Death (HIV+) : The commonest primary causes of death in HIV-positive individuals have been: [cause #(%)] AIDS 284(70), liver failure 45(11), bleeding 18(4.4) and infections 15(3.7). Twenty-eight patients had liver disease listed as a secondary or contributing cause of death; thus liver disease was the primary or contributory cause of death in 45+28=73 individuals (18% of HIV-positive deaths). HCV-Related Deaths : HCV status is positive in 1151 of the total population of 3307 (35%) individuals in the registry, negative in 1260 (38%) and unknown in 896 (27%). Of HIV-positive individuals, 448 (68%) are co-infected with HCV, 53 of whom have died with liver failure (12% overall, 18% of deaths). HIV/HCV co-infected individuals have higher overall mortality than those not co-infected (46% vs. 12%, p<0.0001). In addition, HCV singly-infected individuals have lower overall mortality (7%). 703 HIV-negative individuals are infected with HCV, of whom 7 have died with liver failure (1% overall, 13% of deaths). Conclusions : The death rate of HIV-positive individuals peaked in the years 1991-3 and decreased thereafter with 38% of individuals still living at 20 years follow up. However deaths still occur at an annual rate of 3–5%. HIV/HCV co-infected individuals have the highest mortality and HCV single-infected individuals have the lowest mortality of those with transfusion-transmitted infection. Liver failure is a common mode of death in both HIV- and HCV-infected individuals.

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