Cabergoline Stimulates Synthesis and Secretion of Nerve Growth Factor, Brain-Derived Neurotrophic Factor and Glial Cell Line-Derived Neurotrophic Factor by Mouse Astrocytes in Primary Culture

Pharmacology ◽  
2004 ◽  
Vol 71 (3) ◽  
pp. 162-168 ◽  
Author(s):  
Kiyoe Ohta ◽  
Aya Fujinami ◽  
Sadako Kuno ◽  
Asuka Sakakimoto ◽  
Hidehito Matsui ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Primary Culture ◽  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Nerve Growth

scholarly journals The roles of glial cell line-derived neurotrophic factor, brain-derived neurotrophic factor and nerve growth factor during the final stage of folliculogenesis: a focus on oocyte maturation

Reproduction ◽  
2013 ◽  
Vol 145 (2) ◽  
pp. R43-R54 ◽  
Author(s):  
Katja Linher-Melville ◽  
Julang Li
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cell Line ◽  
Glial Cell ◽  
Oocyte Maturation ◽  
Neurotrophic Factor ◽  
Final Stage ◽  
Brain Derived Neurotrophic Factor ◽  
Peripheral Tissues ◽  
Nerve Growth

Neurotrophic factors were first identified to promote the growth, survival or differentiation of neurons and have also been associated with the early stages of ovarian folliculogenesis. More recently, their effects on the final stage of follicular development, including oocyte maturation and early embryonic development, have been reported. Glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), which are expressed in numerous peripheral tissues outside of the CNS, most notably the ovary, are now known to stimulate oocyte maturation in various species, also enhancing developmental competence. The mechanisms that underlie their actions in antral follicles, as well as the targets ultimately controlled by these factors, are beginning to emerge. GDNF, BDNF and NGF, alone or in combination, could be added to the media currently utilized forin vitrooocyte maturation, thereby potentially increasing the production and/or quality of early embryos.

Regulation of nociceptive neurons by nerve growth factor and glial cell line derived neurotrophic factor

2002 ◽  
Vol 80 (5) ◽  
pp. 495-505 ◽  
Author(s):  
J V Priestley ◽  
G J Michael ◽  
S Averill ◽  
M Liu ◽  
N Willmott
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Dorsal Root Ganglion ◽  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Dorsal Root ◽  
Small Diameter ◽  
Nerve Growth ◽  
Nociceptive Neurons

Nociceptive dorsal root ganglion (DRG) cells can be divided into three main populations, namely (1) small diameter non-peptide-expressing cells, (2) small-diameter peptide-expressing (calcitonin gene related peptide (CGRP), substance P) cells, and (3) medium-diameter peptide-expressing (CGRP) cells. The properties of these cell populations will be reviewed, with a special emphasis on the expression of the vanilloid (capsaicin) receptor VR1 and its regulation by growth factors. Cells in populations 1 and 2 express VR1, a nonselective channel that transduces certain nociceptive stimuli and that is crucial to the functioning of polymodal nociceptors. Cells in population 1 can be regulated by glial cell line derived neurotrophic factor (GDNF) and those in populations 2 and 3 by nerve growth factor (NGF). In vivo, DRG cells express a range of levels of VR1 expression and VR1 is downregulated after axotomy. However, treatment with NGF or GDNF can prevent this downregulation. In vitro, DRG cells also show a range of VR1 expression levels that is NGF and (or) GDNF dependent. Functional studies indicate that freshly dissociated cells also show differences in sensitivity to capsaicin. The significance of this is not known but may indicate a difference in the physiological role of cells in populations 1 and 2.Key words: nociceptors, CGRP, IB4, vanilloid, dorsal root ganglion.

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