Effect of Epidermal Growth Factor on the Developing Rat Renal Papilla

2004 ◽  
Vol 24 (2) ◽  
pp. 212-220 ◽  
Author(s):  
Seung-Hun Lee ◽  
Ju-Young Jung ◽  
Ki-Hwan Han ◽  
Chul-Woo Yang ◽  
Kyu-Bok Choi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Renal Papilla ◽  
Epidermal Growth ◽  
Developing Rat

Processing and transfer of epidermal growth factor in developing rat jejunum and ileum

Peptides ◽  
1990 ◽  
Vol 11 (6) ◽  
pp. 1093-1102 ◽  
Author(s):  
R.K. Rao ◽  
O. Koldovský ◽  
M. Korc ◽  
P.F. Pollack ◽  
S. Wright ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Rat Jejunum ◽  
Epidermal Growth ◽  
Developing Rat

Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor

Development ◽  
1993 ◽  
Vol 118 (3) ◽  
pp. 777-784 ◽  
Author(s):  
H.S. Coles ◽  
J.F. Burne ◽  
M.C. Raff
Keyword(s):  
Cell Death ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Normal Cell ◽  
Large Scale ◽  
Kidney Development ◽  
Rat Kidney ◽  
Survival Factors ◽  
Epidermal Growth ◽  
Developing Rat

Although normal cell death is known to occur in many developing vertebrate organs, it has not been thought to play an important part in the development of the mammalian kidney. We show here that normal cell death is found in both the nephrogenic region and medullary papilla of the developing rat kidney and, in each of these areas, it follows a distinct developmental time course. As many as 3% of the cells in these areas have a typical apoptotic morphology and the dead cells seem to be cleared rapidly (within 1–2 hours) by phagocytosis by neighbouring parenchymal cells. These values are similar to those in vertebrate neural tissues where 50% or more of the cells die during normal development, suggesting that large-scale death is a normal feature of kidney development. We also show that in vivo treatment with epidermal growth factor inhibits cell death in the developing kidney, consistent with the possibility that the cells normally die because they lack sufficient survival factors. Our findings suggest that the extent of normal cell death in developing animals is still greatly underestimated and they raise the possibility that many of these cell deaths may reflect limiting amounts of survival factors.

Expression of epidermal growth factor in the developing rat kidney

2005 ◽  
Vol 288 (1) ◽  
pp. F227-F235 ◽  
Author(s):  
Ju-Young Jung ◽  
Ji-Hyun Song ◽  
Can Li ◽  
Chul-Woo Yang ◽  
Tae-Cheon Kang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Kidney Development ◽  
Rat Kidney ◽  
Distal Tubule ◽  
Distal Convoluted Tubule ◽  
Thick Ascending Limb ◽  
Epidermal Growth ◽  
Developing Kidney ◽  
Developing Rat

Epidermal growth factor (EGF) is important in mammalian renal development. In our study, we investigated the detailed distribution and the time of the first appearance of EGF in developing rat kidney. Kidneys from embryonic 18 ( E18)- and 20-day-old ( E20) fetuses, postnatal 1 ( P1)-, 3 ( P3)-, 7 ( P7)-, 14 ( P14)-, and 21-day-old ( P21) pups, and adults were processed for immunohistochemistry and electronmicroscopy. In adult rat kidney, EGF immunoreactivity was found in distal tubule including the thick ascending limb (TAL) and portion 1 of distal convoluted tubule (DCT1), whereas no EGF immunoreactivity was seen in portion 2 of distal convoluted tubule (DCT2) and connecting tubule. In developing kidney, EGF-positive cells first appeared at P3 and were localized in the middle portion of the differentiating TAL of the corticomedullary junction. By P7, the abundance of EGF expression had dramatically increased in the medullary TAL. Between P14 and P21, EGF immunoreactivity was found in the TAL and the DCT for the first time. However, EGF-positive and EGF-negative cells were in the TAL in developing rat kidney. EGF-positive cells did not differ from negative cells in the expression of sodium transport proteins or in the proliferation rate at P3 and P7. In the TAL, smooth-surfaced cells had strong EGF immunoreactivity, but no EGF immunoreactivity was seen in the rough-surfaced cells with well-developed microvilli. Our results suggest that the expression of EGF in developing kidney plays an important role in the regulation of growth and differentiation of the loop of Henle during kidney development and that this may act in the paracrine mode.

Epidermal growth factor enemas are effective in the treatment of left-sided ulcarative colitis

2001 ◽  
Vol 120 (5) ◽  
pp. A11-A12 ◽  
Author(s):  
A SINHA ◽  
J NIGHTINGALE ◽  
K WEST ◽  
R PLAYFORD
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Epidermal Growth
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