scholarly journals Nicotinic Activation of Mesolimbic Neurons Assessed by Rubidium Efflux in Rat Accumbens and Ventral Tegmentum

Neurosignals ◽  
2004 ◽  
Vol 13 (3) ◽  
pp. 114-121 ◽  
Author(s):  
Peter P. Rowell ◽  
Kelly A. Volk
Keyword(s):  
Ventral Tegmentum ◽  
Rubidium Efflux

MESENCEPHALIC AREAS CONTROLLING PULSATILE OXYTOCIN RELEASE IN THE SUCKLED RAT

1981 ◽  
Vol 91 (2) ◽  
pp. 233-244 ◽  
Author(s):  
T. S. JUSS ◽  
J. B. WAKERLEY
Keyword(s):  
Medial Geniculate Body ◽  
Milk Ejection ◽  
Ventral Tegmentum ◽  
Irregular Pattern ◽  
Oxytocin Release ◽  
Medial Geniculate ◽  
Radiofrequency Lesions ◽  
Milk Ejection Reflex ◽  
Bilateral Lesions ◽  
And Control

Experiments were performed on anaesthetized lactating rats to investigate the effects of radiofrequency lesions of the mesencephalon on the milk-ejection reflex. In lesioned and control rats, intramammary pressure recordings were used to estimate oxytocin release (number and relative amplitude of the intermittent milk-ejection responses) during a 3-h suckling test with ten pups. Bilateral lesions (diameter 0·5–1·5 mm) of the lateral tegmentum (near the brachium of the inferior colliculus and medial geniculate body) seriously disrupted the milk-ejection reflex, reducing the number of rats ejecting milk (two out of ten v. all 12 controls, P<0·001) and the amount of oxytocin they released (1·35±0·35 (s.e.m.) v. 15·52±2·19 mu. for controls, P<0·05). Unilateral lesions of the lateral tegmentum also impaired milk ejection and, if the suckling stimulus was restricted only to the contralateral nipples, oxytocin release was virtually abolished. Bilateral lesions placed more medially in the intermediate tegmentum were far less disruptive (eight out of nine rats ejected milk), though the amount of oxytocin released in this group (8·64±1·88 mu.) was still significantly (P<0·05) lower than controls. All rats with lesions of the central grey (nine) or ventral tegmentum (eight) displayed reflex milk ejection, as did those with multiple lesions of the tectum, central grey and ventral tegmentum (seven); in these three groups the amounts of oxytocin released (13·88±2·68, 13·10±1·90 and 11·04±1·95 mu. respectively) did not differ significantly from controls. Damage to the ventral tegmentum produced an irregular pattern of milk ejection characterized by occasional abnormally short (<2 min) milk-ejection intervals, though the overall number of responses in 3 h was less than that of controls (20·83±1·82 v. 14·50±1·30 mu., P<0·05). In conclusion, these results delineate two mesencephalic areas of particular importance in the milk-ejection reflex: (a) the lateral tegmentum, which appears to be concerned with transmission of the suckling stimulus from the contralateral nipples and is indispensable for oxytocin release, and (b) the ventral tegmentum which, although not an essential component of the reflex, may contribute to the timing of the intermittent milk-ejection responses.

Oxytocin and cholecystokinin induced grooming behavior in the ventral tegmentum of the rat

1987 ◽  
Vol 426 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Maria-Th. Kaltwasser ◽  
Jacqueline N. Crawley
Keyword(s):  
Grooming Behavior ◽  
Ventral Tegmentum

scholarly journals Endocannabinoids Shape Accumbal Encoding of Cue-Motivated Behavior via CB1 Receptor Activation in the Ventral Tegmentum

Neuron ◽  
2012 ◽  
Vol 73 (2) ◽  
pp. 360-373 ◽  
Author(s):  
Erik B. Oleson ◽  
Michael V. Beckert ◽  
Joshua T. Morra ◽  
Carien S. Lansink ◽  
Roger Cachope ◽  
...  
Keyword(s):  
Receptor Activation ◽  
Cb1 Receptor ◽  
Ventral Tegmentum ◽  
Motivated Behavior

Silver impregnation of dopaminergic systems after radiofrequency and 6-OHDA lesions of the rat ventral tegmentum

1976 ◽  
Vol 115 (2) ◽  
pp. 215-231 ◽  
Author(s):  
Hervé Simon ◽  
Michel Le Moal ◽  
Daniel Galey ◽  
Bernard Cardo
Keyword(s):  
Silver Impregnation ◽  
Ventral Tegmentum ◽  
Dopaminergic Systems
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