T Cell Prolymphocytic Leukemia with New Chromosome Rearrangements

2004 ◽  
Vol 111 (3) ◽  
pp. 168-170
Author(s):  
Samo Zver ◽  
Nadja Kokalj Vokac ◽  
Boris Zagradisnik ◽  
Alenka Erjavec ◽  
Andreja Zagorac ◽  
...  
Keyword(s):  
T Cell ◽  
Chromosome Rearrangements ◽  
Prolymphocytic Leukemia

Recurrent molecular deletion of the 12p13 region, centromeric to ETV6/TEL, in T-cell prolymphocytic leukemia

2000 ◽  
Vol 1 (1) ◽  
pp. 42-47 ◽  
Author(s):  
G Hetet ◽  
H Dastot ◽  
M Baens ◽  
A Brizard ◽  
F Sigaux ◽  
...  
Keyword(s):  
T Cell ◽  
Prolymphocytic Leukemia

scholarly journals The distinctive cytological features of T-cell prolymphocytic leukemia

2017 ◽  
Vol 92 (8) ◽  
pp. 830-832 ◽  
Author(s):  
Vishal Jayakar ◽  
Kan Cheung ◽  
Eva Yebra-Fernandez ◽  
Barbara J. Bain
Keyword(s):  
T Cell ◽  
Prolymphocytic Leukemia ◽  
Cytological Features

scholarly journals SAMHD1 IS FREQUENTLY INVOLVED IN T-CELL PROLYMPHOCYTIC LEUKEMIA (T-PLL) PATHOGENESIS

2017 ◽  
Vol 35 ◽  
pp. 164-164 ◽  
Author(s):  
P. Johansson ◽  
L. Klein-Hitpass ◽  
A.K. Bergmann ◽  
R. Siebert ◽  
R. Scholtysik ◽  
...  
Keyword(s):  
T Cell ◽  
Prolymphocytic Leukemia

scholarly journals Clinically and genetically atypical T-cell prolymphocytic leukemia underlines the relevance of a multidisciplinary diagnostic approach

Haematologica ◽  
2007 ◽  
Vol 92 (3) ◽  
pp. e34-e36 ◽  
Author(s):  
Y. Sandberg ◽  
K.L. Wu ◽  
F. Heule ◽  
R.R. van den Bos ◽  
K.H. Lam ◽  
...  
Keyword(s):  
T Cell ◽  
Diagnostic Approach ◽  
Prolymphocytic Leukemia

Linear nonpalpable purpura in a young male: a unique presentation of leukemia cutis in T-cell prolymphocytic leukemia

2017 ◽  
Vol 56 (3) ◽  
pp. e65-e67 ◽  
Author(s):  
Geeti Khullar ◽  
Saurabh Singh ◽  
Saurabh Agrawal ◽  
Man Updesh Singh Sachdeva ◽  
Uma Nahar Saikia
Keyword(s):  
T Cell ◽  
Young Male ◽  
Prolymphocytic Leukemia ◽  
Leukemia Cutis

scholarly journals Rearrangement and expression of T cell antigen receptor genes in B cell chronic lymphocytic leukemia

Blood ◽  
1988 ◽  
Vol 71 (1) ◽  
pp. 178-185
Author(s):  
JD Norton ◽  
J Pattinson ◽  
AV Hoffbrand ◽  
H Jani ◽  
JC Yaxley ◽  
...  
Keyword(s):  
T Cell ◽  
Chronic Lymphocytic Leukemia ◽  
B Cell ◽  
Germ Line ◽  
Lymphocytic Leukemia ◽  
Gene Transcript ◽  
Prolymphocytic Leukemia ◽  
Beta 2 ◽  
Beta Gene ◽  
Cell Chronic Lymphocytic Leukemia

Fifty-nine patients with B cell chronic lymphocytic leukemia (B-CLL) were screened for clonal rearrangement of T cell receptor (TCR) beta and gamma chain genes. Four were found with rearranged TCR beta genes, but none had detectable rearrangement of TCR gamma genes. One typical patient with B-CLL had a TCR beta gene structure consistent with a variable-diversity-joining rearrangement into the C beta 2 gene on one allele. An apparently identical rearrangement pattern was seen in a second patient, which suggested that there may be a restriction on the repertoire of possible TCR beta gene recombinations in mature B cells. Two further patients had a simple deletion of sequences, consistent with a diversity-joining rearrangement into C beta 2 on one allele. All four patients had rearrangements of immunoglobulin heavy- and light- chain genes typical of mature B cell malignancies. However, on review of clinical, morphological, and immunophenotype data, two had features consistent with B cell prolymphocytic leukemia or B lymphoma, and a third had progressed to a prolymphocytic transformation. Low-level expression of a predominantly 1.0- to 1.2-kilobase germ line TCR beta gene transcript was detected in several B-CLLs and at a comparable level in the four with rearranged TCR beta genes. This, together with the low frequency of TCR gene rearrangement, suggests that most B-CLL cases arise at a developmental stage when factors required for TCR gene activity are not operative.

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