The Fas Promoter Polymorphism at Position –670 Is Not Associated with Late-Onset Sporadic Alzheimer’s Disease

2004 ◽  
Vol 17 (3) ◽  
pp. 143-146 ◽  
Author(s):  
Hanna Rosenmann ◽  
Zeev Meiner ◽  
Esther Kahana ◽  
Zoja Aladjem ◽  
Gideon Friedman ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Late Onset ◽  
Promoter Polymorphism ◽  
Sporadic Alzheimer’S Disease

The Role of Microglia in Sporadic Alzheimer’s Disease

2021 ◽  
Vol 79 (3) ◽  
pp. 961-968
Author(s):  
Wolfgang J. Streit ◽  
Habibeh Khoshbouei ◽  
Ingo Bechmann
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Late Onset ◽  
Genetic Mutations ◽  
Sporadic Alzheimer’S Disease ◽  
Immune Effector ◽  
Effector Cells ◽  
Immune Effector Cells ◽  
Amyloid Cascade

Microglia constitute the brain’s immune system and their involvement in Alzheimer’s disease has been discussed. Commonly, and in line with the amyloid/neuroinflammation cascade hypothesis, microglia have been portrayed as potentially dangerous immune effector cells thought to be overactivated by amyloid and producing neurotoxic inflammatory mediators that lead to neurofibrillary degeneration. We disagree with this theory and offer as an alternative the microglial dysfunction theory stating that microglia become impaired in their normally neuroprotective roles because of aging, i.e., they become senescent and aging neurons degenerate because they lack the needed microglial support for their survival. Thus, while the amyloid cascade theory relies primarily on genetic data, the dysfunction theory incorporates aging as a critical etiological factor. Aging is the greatest risk factor for the sporadic (late-onset) and most common form of Alzheimer’s disease, where fully penetrant genetic mutations are absent. In this review, we lay out and discuss the human evidence that supports senescent microglial dysfunction and conflicts with the amyloid/neuroinflammation idea.

APOE -491 promoter polymorphism is a risk factor for late-onset Alzheimer's disease

Neurology ◽  
1999 ◽  
Vol 53 (8) ◽  
pp. 1888-1888 ◽  
Author(s):  
V. M. Casadei ◽  
C. Ferri ◽  
F. Veglia ◽  
A. Gavazzi ◽  
G. Salani ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Late Onset ◽  
Promoter Polymorphism

Apolipoprotein is a susceptibility genetic locus that affects the expression of late-onset familial and sporadic Alzheimer's disease

1996 ◽  
Vol 39 (7) ◽  
pp. 562
Author(s):  
A.D. Roses ◽  
A.M. Saunders ◽  
M.A. Pericak-Vance ◽  
G. Einstein ◽  
C. Hulette ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Late Onset ◽  
Genetic Locus ◽  
Sporadic Alzheimer’S Disease

scholarly journals Association of apolipoprotein E allele  4 with late-onset familial and sporadic Alzheimer's disease

Neurology ◽  
2011 ◽  
Vol 77 (10) ◽  
pp. 950-950 ◽  
Author(s):  
A. M. Saunders ◽  
W. J. Strittmatter ◽  
D. Schmechel ◽  
P. H. St. George-Hyslop ◽  
M. A. Pericak-Vance ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Late Onset ◽  
Sporadic Alzheimer’S Disease

Presenilin 2 Ser130Leu mutation in a case of late-onset “sporadic” Alzheimer’s disease

2007 ◽  
Vol 254 (3) ◽  
pp. 391-393 ◽  
Author(s):  
Carmine Tomaino ◽  
Livia Bernardi ◽  
Maria Anfossi ◽  
Angela Costanzo ◽  
Francesca Ferrise ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Late Onset ◽  
Sporadic Alzheimer’S Disease ◽  
Presenilin 2

[P2-122]: CDK5RAP2 GENE AND TAU PATHOPHYSIOLOGY IN LATE-ONSET SPORADIC ALZHEIMER's DISEASE

2017 ◽  
Vol 13 (7S_Part_13) ◽  
pp. P654-P654
Author(s):  
Justin Miron ◽  
Cynthia Picard ◽  
Josée Frappier ◽  
Doris Dea ◽  
Louise Théroux ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Late Onset ◽  
Sporadic Alzheimer’S Disease

Association of apolipoprotein E allele ε4 with late-onset sporadic Alzheimer's disease

1994 ◽  
Vol 54 (3) ◽  
pp. 286-288 ◽  
Author(s):  
G. Lucotte ◽  
S. Visvikis ◽  
B. Leininger-Möler ◽  
F. David ◽  
S. Berriche ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Late Onset ◽  
Sporadic Alzheimer’S Disease
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