Modulation of Neuroendocrine Response and Non-Verbal Behavior during Psychosocial Stress in Healthy Volunteers by the Glutamate Release-Inhibiting Drug Lamotrigine

2004 ◽  
Vol 79 (1) ◽  
pp. 34-42 ◽  
Author(s):  
Aikaterini Makatsori ◽  
Roman Duncko ◽  
Fedor Moncek ◽  
Ingrid Loder ◽  
Stanislav Katina ◽  
...  
Keyword(s):  
Verbal Behavior ◽  
Healthy Volunteers ◽  
Psychosocial Stress ◽  
Glutamate Release ◽  
Neuroendocrine Response

PATIENTS WITH ATOPY EXHIBITED ATTENUATED NEUROENDOCRINE RESPONSE DURING PSYCHOSOCIAL STRESS

2018 ◽  
Vol 25 (3) ◽  
pp. 202
Author(s):  
Natasa Hlavacova ◽  
Petra Solarikova ◽  
Igor Brezina ◽  
Daniela Jezova
Keyword(s):  
Psychosocial Stress ◽  
Neuroendocrine Response

Behavioral and neuroendocrine response to psychosocial stress in male rats: The effects of the 5-HT 1A agonist ipsapirone

1990 ◽  
Vol 24 (4) ◽  
pp. 554-567 ◽  
Author(s):  
S.Mechiel Korte ◽  
Jenneke Smit ◽  
Gerdien A.H Bouws ◽  
Jaap M Koolhaas ◽  
Béla Bohus
Keyword(s):  
Psychosocial Stress ◽  
Male Rats ◽  
Neuroendocrine Response

scholarly journals Repeatability of Neural and Autonomic Responses to Acute Psychosocial Stress

2020 ◽  
Vol 14 ◽  
Author(s):  
Adam M. Goodman ◽  
Michael David Diggs ◽  
Neha Balachandran ◽  
Pranav S. Kakulamarri ◽  
Robert A. Oster ◽  
...  
Keyword(s):  
Heart Rate ◽  
Healthy Volunteers ◽  
Auditory Feedback ◽  
Psychosocial Stress ◽  
Cingulate Cortex ◽  
Math Performance ◽  
Alpha Amylase ◽  
Salivary Alpha Amylase ◽  
Before And After ◽  
Acute Psychosocial Stress

FMRI Montreal Imaging Stress Tasks (MIST) have been shown to activate endocrine and autonomic stress responses that are mediated by a prefrontal cortex (PFC)-hippocampus-amygdala circuit. However, the stability of the neurobehavioral responses over time and the ability to monitor response to clinical interventions has yet to be validated. The objective of this study was to compare the fMRI and physiologic responses to acute psychosocial stress in healthy volunteers during initial and follow-up visits approximately 13 weeks later, simulating a typical duration of clinical intervention. We hypothesized that responses to stress would remain highly conserved across the 2 visits in the absence of an intervention. 15 healthy volunteers completed a variant of control math task (CMT) and stress math task (SMT) conditions based on MIST. Neural responses were modeled using an event-related design with estimates for math performance and auditory feedback for each task condition. For each visit, measures of stress reactivity included differential fMRI and heart rate (SMT-CMT), as well as salivary alpha-amylase before and after scanning sessions. The results revealed that differential fMRI, as well as increased heart rate and salivary alpha-amylase from before and after scanning remained similar between visits. Intraclass correlation coefficient (ICC) values revealed areas of reliable task-dependent BOLD fMRI signal response across visits for peaks of clusters for the main effect of condition (SMT vs CMT) within dorsal anterior cingulate cortex (ACC), insula, and hippocampus regions during math performance and within subgenual ACC, posterior cingulate cortex, dorsolateral PFC regions during auditory feedback. Given that the neurobehavioral response to acute stress remained highly conserved across visits in the absence of an intervention, this study confirms the utility for MIST for assessing longitudinal changes in controlled trials that can identify underlying neurobiological mechanisms involved in mediating the efficacy of stress-reduction interventions.

Determining Emotional Tone and Verbal Behavior in Patients With Tinnitus and Hyperacusis: An Exploratory Mixed-Methods Study

2019 ◽  
Vol 28 (3) ◽  
pp. 660-672
Author(s):  
Suzanne H. Kimball ◽  
Toby Hamilton ◽  
Erin Benear ◽  
Jonathan Baldwin
Keyword(s):  
Mixed Methods ◽  
Verbal Behavior ◽  
Coping Strategies ◽  
Mixed Methods Study ◽  
Self Report ◽  
Anxiety And Depression ◽  
Negative Consequences ◽  
Emotional Tone ◽  
Explanatory Mixed Methods ◽  
Quantitative Results

Purpose The purpose of this study was to evaluate the emotional tone and verbal behavior of social media users who self-identified as having tinnitus and/or hyperacusis that caused self-described negative consequences on daily life or health. Research Design and Method An explanatory mixed-methods design was utilized. Two hundred “initial” and 200 “reply” Facebook posts were collected from members of a tinnitus group and a hyperacusis group. Data were analyzed via the LIWC 2015 software program and compared to typical bloggers. As this was an explanatory mixed-methods study, we used qualitative thematic analyses to explain, interpret, and illustrate the quantitative results. Results Overall, quantitative results indicated lower overall emotional tone for all categories (tinnitus and hyperacusis, initial and reply), which was mostly influenced by higher negative emotion. Higher levels of authenticity or truth were found in the hyperacusis sample but not in the tinnitus sample. Lower levels of clout (social standing) were indicated in all groups, and a lower level of analytical thinking style (concepts and complex categories rather than narratives) was found in the hyperacusis sample. Additional analysis of the language indicated higher levels of sadness and anxiety in all groups and lower levels of anger, particularly for initial replies. These data support prior findings indicating higher levels of anxiety and depression in this patient population based on the actual words in blog posts and not from self-report questionnaires. Qualitative results identified 3 major themes from both the tinnitus and hyperacusis texts: suffering, negative emotional tone, and coping strategies. Conclusions Results from this study suggest support for the predominant clinical view that patients with tinnitus and hyperacusis have higher levels of anxiety and depression than the general population. The extent of the suffering described and patterns of coping strategies suggest clinical practice patterns and the need for research in implementing improved practice plans.

Stereoselective pharmacokinetics of S-salbutamol after administration of the racemate in healthy volunteers

1999 ◽  
Vol 13 (6) ◽  
pp. 1230 ◽  
Author(s):  
B Schmekel ◽  
I Rydberg ◽  
B Norlander ◽  
K.n Sjöswärd ◽  
J Ahlner ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Stereoselective Pharmacokinetics
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