Membrane Complement Regulatory Proteins in Autoimmune and Inflammatory Tissue Injury

2003 ◽  
pp. 181-199 ◽  
Author(s):  
W.-C. Song
Keyword(s):  
Tissue Injury ◽  
Regulatory Proteins ◽  
Complement Regulatory Proteins ◽  
Inflammatory Tissue

The expression of membrane-bound complement regulatory proteins CD46, CD55 and CD59 in oral lichen planus

2021 ◽  
Vol 124 ◽  
pp. 105064
Author(s):  
Lulu Li ◽  
Beibei Cong ◽  
Xixi Yu ◽  
Songsong Deng ◽  
Mengjia Liu ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Regulatory Proteins ◽  
Complement Regulatory Proteins ◽  
Membrane Bound ◽  
Oral Lichen

Application of Protein A-Rosette Assay for Screening of Monoclonal Antibodies to Human Complement Regulatory Proteins

1990 ◽  
Vol 7 (2) ◽  
pp. 78-89 ◽  
Author(s):  
Tsukasa Seya ◽  
Tomoko Hara ◽  
Akiko Uenaka ◽  
Eiichi Nakayama ◽  
Hitoshi Akedo
Keyword(s):  
Monoclonal Antibodies ◽  
Protein A ◽  
Regulatory Proteins ◽  
Human Complement ◽  
Complement Regulatory Proteins

X-Irradiation Does Not Affect the Levels of Complement Regulatory Proteins, CD35 (CR1), CD55 (DAF) and CD59 on Concentrated Red Cells

Vox Sanguinis ◽  
1996 ◽  
Vol 71 (4) ◽  
pp. 243-244
Author(s):  
Yasuo Fukumori ◽  
Tsukasa Seya ◽  
Shiro Ohnoki ◽  
Hirotoshi Shibata ◽  
Hideo Yamaguchi
Keyword(s):  
Red Cells ◽  
Regulatory Proteins ◽  
Complement Regulatory Proteins ◽  
X Irradiation

Role of complement regulatory proteins CD46, CD55 and CD59 in reproduction

2012 ◽  
Vol 61 (1) ◽  
pp. 84-94 ◽  
Author(s):  
Michaela Frolíková ◽  
Romana Stopková ◽  
Jana Antalíková ◽  
Peter M. Johnson ◽  
Pavel Stopka ◽  
...  
Keyword(s):  
Regulatory Proteins ◽  
Complement Regulatory Proteins

scholarly journals Binding of complement regulatory proteins to Group A Streptococcus

Vaccine ◽  
2008 ◽  
Vol 26 ◽  
pp. I75-I78 ◽  
Author(s):  
Maria A. Oliver ◽  
José M. Rojo ◽  
Santiago Rodríguez de Córdoba ◽  
Sebastián Alberti
Keyword(s):  
Group A Streptococcus ◽  
Regulatory Proteins ◽  
Complement Regulatory Proteins ◽  
Group A

scholarly journals Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome

Blood ◽  
2006 ◽  
Vol 108 (4) ◽  
pp. 1267-1279 ◽  
Author(s):  
Jessica Caprioli ◽  
Marina Noris ◽  
Simona Brioschi ◽  
Gaia Pianetti ◽  
Federica Castelletti ◽  
...  
Keyword(s):  
Disease Recurrence ◽  
Factor H ◽  
Response To Therapy ◽  
Regulatory Proteins ◽  
Response To Treatment ◽  
Complement Factor ◽  
Genetic Studies ◽  
Complement Regulatory Proteins ◽  
Uremic Syndrome ◽  
The Impact

Abstract Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy with manifestations of hemolytic anemia, thrombocytopenia, and renal impairment. Genetic studies have shown that mutations in complement regulatory proteins predispose to non–Shiga toxin–associated HUS (non-Stx–HUS). We undertook genetic analysis on membrane cofactor protein (MCP), complement factor H (CFH), and factor I (IF) in 156 patients with non-Stx–HUS. Fourteen, 11, and 5 new mutational events were found in MCP, CFH, and IF, respectively. Mutation frequencies were 12.8%, 30.1%, and 4.5% for MCP, CFH, and IF, respectively. MCP mutations resulted in either reduced protein expression or impaired C3b binding capability. MCP-mutated patients had a better prognosis than CFH-mutated and nonmutated patients. In MCP-mutated patients, plasma treatment did not impact the outcome significantly: remission was achieved in around 90% of both plasma-treated and plasma-untreated acute episodes. Kidney transplantation outcome was favorable in patients with MCP mutations, whereas the outcome was poor in patients with CFH and IF mutations due to disease recurrence. This study documents that the presentation, the response to therapy, and the outcome of the disease are influenced by the genotype. Hopefully this will translate into improved management and therapy of patients and will provide the way to design tailored treatments.

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