Endogenous Nitric Oxide Reduces Microvascular Permeability and Tissue Oedema during Exercise in Cat Skeletal Muscle

2003 ◽  
Vol 40 (6) ◽  
pp. 538-546 ◽  
Author(s):  
Johan Persson ◽  
Ulf Ekelund ◽  
Per Olof Grände
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Microvascular Permeability ◽  
Endogenous Nitric Oxide ◽  
Tissue Oedema

Endogenous nitric oxide in the control of skeletal muscle oxygen extraction during exercise

2000 ◽  
Vol 168 (4) ◽  
pp. 675-686 ◽  
Author(s):  
W. Shen ◽  
X. Xu ◽  
M. Ochoa ◽  
G. Zhao ◽  
R.D. Bernstein ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Oxygen Extraction ◽  
Muscle Oxygen ◽  
Endogenous Nitric Oxide

Regional transcapillary albumin exchange in rodent endotoxaemia: effects of fluid resuscitation and inhibition of nitric oxide synthase

2000 ◽  
Vol 100 (1) ◽  
pp. 81-89 ◽  
Author(s):  
Suveer SINGH ◽  
Peter B. ANNING ◽  
C. Peter WINLOVE ◽  
Timothy W. EVANS
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Surface Area ◽  
Blood Volume ◽  
Fluid Resuscitation ◽  
Volume Ratio ◽  
Capillary Density ◽  
Microvascular Permeability ◽  
Capillary Perfusion ◽  
Dual Isotope

Sepsis is characterized by increased microvascular permeability and regional variations in capillary perfusion, which may be modulated by nitric oxide (NO) and reversed by fluid resuscitation (FR). The effects of saline FR and NO synthase blockade [by NG-nitro-L-arginine methyl ester (L-NAME)] on microvascular albumin transport and perfused capillary density were assessed in anaesthetized Wistar rats with acute normodynamic endotoxaemia. Separate dual-isotope techniques were employed to measure the permeability index (PIA) and the permeability×surface area product index (PIB), which provide different and complementary information regarding blood–tissue albumin exchange. PIA represents the tissue/blood distribution volume ratio of albumin. PIB is a composite measure of endothelial permeability and the vascular surface area available for albumin exchange, and therefore takes into account the effect of altered blood volume. Capillary density was quantified by fluorescence microscopy following circulation of Evans Blue-labelled albumin. Compared with controls, PIA was reduced significantly in lipopolysaccharide (LPS)-treated animals in skeletal muscle and skin, probably due to blood volume redistribution rather than to changes in permeability. PIB was increased significantly in LPS-treated animals in the kidney, mesentery, skeletal muscle, skin and lung, and in the small bowel following FR. FR also improved the LPS-induced metabolic base deficit, but did not alter capillary density. L-NAME significantly attenuated the LPS-induced rise in PIB in the lung. In conclusion, acute endotoxaemia induces tissue-dependent variations in microvascular albumin exchange. FR improves acid–base disturbance in endotoxaemia, through mechanisms other than microvascular recruitment. NO appears to increase microvascular permeability in endotoxaemia, an effect that may be attenuated by L-NAME, particularly in the lung.

scholarly journals Concerted regulation of skeletal muscle contractility by oxygen tension and endogenous nitric oxide

2003 ◽  
Vol 100 (25) ◽  
pp. 15229-15234 ◽  
Author(s):  
J. P. Eu ◽  
J. M. Hare ◽  
D. T. Hess ◽  
M. Skaf ◽  
J. Sun ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Oxygen Tension ◽  
Muscle Contractility ◽  
Endogenous Nitric Oxide

scholarly journals Endogenous nitric oxide as a modulator of rabbit skeletal muscle microcirculation in vivo

1990 ◽  
Vol 100 (3) ◽  
pp. 463-466 ◽  
Author(s):  
M.G. Persson ◽  
L.E. Gustafsson ◽  
N.P. Wikludn ◽  
P. Hedqvist ◽  
S. Moncada
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Rabbit Skeletal Muscle ◽  
Endogenous Nitric Oxide ◽  
Skeletal Muscle Microcirculation

Expression of nitric oxide synthase in skeletal muscle: a novel role for nitric oxide as a modulator of insulin action

Diabetes ◽  
1997 ◽  
Vol 46 (11) ◽  
pp. 1691-1700 ◽  
Author(s):  
S. Kapur ◽  
S. Bedard ◽  
B. Marcotte ◽  
C. H. Cote ◽  
A. Marette
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Nitric Oxide Synthase ◽  
Insulin Action ◽  
Oxide Synthase

Increased cardiac microvascular permeability and activation of cardiac endothelial nitric oxide synthase in high tidal volume ventilation-induced lung injury

2010 ◽  
Vol 4 (1) ◽  
pp. 27-36
Author(s):  
Ming-Jui Hung ◽  
Ming-Yow Hung ◽  
Wen-Jin Cherng ◽  
Li-Fu Li
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Lung Injury ◽  
Tidal Volume ◽  
Endothelial Nitric Oxide Synthase ◽  
Microvascular Permeability ◽  
Akt Phosphorylation ◽  
Enos Phosphorylation ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Abstract Background: Positive pressure ventilation with large tidal volumes has been shown to cause lung injury via the serine/threonine kinase-protein kinase B (Akt) and endothelial nitric oxide synthase (eNOS)-pathways. However, the effects of high tidal volume (VT) ventilation on the heart are unclear. Objectives: Evaluate the effect of VT ventilation on the cardiac vascular permeability and intracellular Akt and eNOS signaling pathway. Methods: C57BL/6 and Akt knock-out (heterozygotes, +/−) mice were exposed to high VT (30 mL/kg) mechanical ventilation with room air for one and/or five hours. Results: High VT ventilation increased cardiac microvascular permeability and eNOS phosphorylation in a timedependent manner. Serum cardiac troponin I was increased after one hour of high VT ventilation. Cardiac Akt phosphorylation was accentuated after one hour and attenuated after five hours of high VT ventilation. Pharmacological inhibition of Akt with LY294002 and high VT ventilation of Akt+/− mice attenuated cardiac Akt phosphorylation, but not eNOS phosphorylation. Conclusion: High VT ventilation increased cardiac myocardial injury, microvascular permeability, and eNOS phosphorylation. Involvement of cardiac Akt in high VT ventilation was transient.

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