Plasma Levels of Coenzyme Q10 in Children with Hyperthyroidism

2004 ◽  
Vol 61 (4) ◽  
pp. 153-158 ◽  
Author(s):  
Thomas Menke ◽  
Petra Niklowitz ◽  
Thomas Reinehr ◽  
Gideon John de Sousa ◽  
Werner Andler
Keyword(s):  
Coenzyme Q10 ◽  
Plasma Levels

Comparison of coenzyme Q10 plasma levels in obese and normal weight children

2004 ◽  
Vol 349 (1-2) ◽  
pp. 121-127 ◽  
Author(s):  
Thomas Menke ◽  
Petra Niklowitz ◽  
Gideon de Sousa ◽  
Thomas Reinehr ◽  
Werner Andler
Keyword(s):  
Coenzyme Q10 ◽  
Plasma Levels ◽  
Normal Weight

Plasma Levels of Vitamins A and E, Coenzyme Q10, and Anti-ox-LDL Antibody Titer in Children Treated with an Elimination Diet Due to Food Hypersensitivity

2009 ◽  
Vol 79 (56) ◽  
pp. 328-336 ◽  
Author(s):  
Bozena Mikoluc ◽  
Radoslaw Motkowski ◽  
Joanna Karpinska ◽  
Janina Piotrowska-Jastrzebska
Keyword(s):  
Antibody Titer ◽  
Coenzyme Q10 ◽  
Plasma Levels ◽  
Oxidized Ldl ◽  
Elimination Diet ◽  
Food Hypersensitivity ◽  
Control Group ◽  
The Status ◽  
Milk Substitute ◽  
Oxidative System

Aim: Has elimination diet applied in children with food hypersensitivity in infancy any effect on plasma levels of anti-oxidative vitamins and antibodies to oxidized low-density lipoprotein (anti-ox-LDL antibody) titer in these children at their pre-school age?” Material: The study involved 92 children (3 to 7 years of age) with food hypersensitivity treated in their infancy and early childhood with soy formula or casein hydrolysate, as a milk substitute for at least 12 months. Control group comprised 62 children, who had never been treated with an elimination diet. Methods: The status of the anti-oxidative system was evaluated by determination of retinol, α-tocopherol, and coenzyme Q10 plasma levels by high-performance liquid chromatography (HPLC). The titer of antibodies to oxidized LDL lipoproteins was specified by immunoenzymatic assay. On the basis of the Results, the following Conclusions have been reached: 1. It was shown that α-tocopherol and retinol levels in pre-school children who had received dietary treatment in their infancy, were higher than in the control group. No deficiencies in anti-oxidative vitamins within the control group were found. 2. A type of milk-substitute formula applied in the elimination diet had no effect on the status of the anti-oxidative system in the children examined.

scholarly journals The Plasma Bioavailability of Coenzyme Q10 Absorbed from the Gut and the Oral Mucosa

2018 ◽  
Vol 9 (4) ◽  
pp. 73 ◽  
Author(s):  
Luis Vitetta ◽  
Andrea Leong ◽  
Joyce Zhou ◽  
Serena Dal Forno ◽  
Sean Hall ◽  
...  
Keyword(s):  
Intestinal Absorption ◽  
Coenzyme Q10 ◽  
Plasma Levels ◽  
Oral Delivery ◽  
Molecular Form ◽  
Chemical Form ◽  
Commercial Supplier ◽  
Comparative Clinical Study ◽  
The Difference ◽  
Poor Absorption

Coenzyme Q10 (CoQ10) has a central role in the generation of cellular bioenergy and its regulation. The hydrophobicity exhibited by the CoQ10 molecule leads to reports of poor absorption profiles, therefore, the optimization of formulations and modes of delivery is an ever-evolving therapeutic goal. The aim of this study was to investigate different CoQ10 formulations. The article summarizes the findings from an Australian comparative study involving adults administered CoQ10 through different oral delivery platforms. A total of 11 participants (six males and five females) voluntarily participated in a comparative clinical study of three different CoQ10 formulations across a six-week period, completing 198 person-hours of cumulative contribution equivalent to n = 33 participation. All of the eligible participants (n = 11) administered the three formulations blinded from who the commercial supplier of the formulation was and from what the chemical form of the CoQ10 was that was being administered. The dosing between the CoQ10 preparations were dispensed sequentially and were administered following three-week washouts. Three commercial preparations were tested, which included the following: formulations with capsules each containing ubiquinol and ubiquinone (150 mg/capsule), and a liposome ubiquinone formulation (40 mg/mL at 2 actuations of the pump). A significant inter-subject variation in the plasma level of CoQ10 at baseline that was observed to increase with an increase in age. This trend persisted in the post administration of the different formulations. Furthermore, it was observed that the intestinal absorption and bioavailability of CoQ10 varied significantly in the plasma between subjects, irrespective of whether the ubiquinol or ubiquinone forms were administered. The administration of CoQ10 as a liposome for preparation showed the poorest response in bioavailability. Although the ubiquinol capsule form of CoQ10 was observed to have increased in the plasma versus the ubiquinone capsules and the ubiquinol liposome at the two-hour interval, the inter-subject variation was such that the difference was not significant (p > 0.05). All of the CoQ10 formulations showed no further increases in their plasma levels over the remaining study period (i.e., four hours). This study further concluded that the intestinal absorption of CoQ10 is highly variable and is independent of the molecular form administered. Furthermore, it also concludes that liposomes are not an effective vehicle for the oral administration of CoQ10, and as such, did not improve the oral mucosal/sublingual absorption and bioavailability of the molecule. Of interest was the observation that with the increasing subject age, there was an observed increase in the baseline plasma CoQ10 levels in the participants prior to dosing. It was posited that the increase in the baseline plasma levels of CoQ10 with an increase in age could be due to the loss of skeletal muscle mass, a result that still needs to be verified.

Plasma levels and redox status of coenzyme Q10 in infants and children

BioFactors ◽  
2004 ◽  
Vol 20 (3) ◽  
pp. 173-181 ◽  
Author(s):  
Thomas Menke ◽  
Petra Niklowitz ◽  
Bernhard Schlüter ◽  
Michael Weber ◽  
Dirk Buschatz ◽  
...  
Keyword(s):  
Coenzyme Q10 ◽  
Plasma Levels ◽  
Redox Status ◽  
Infants And Children ◽  
In Infants And Children
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