Compositional Lipoprotein Changes and Low-Density Lipoprotein Susceptibility to Oxidation in Chronic Renal Failure Patients with Heavy Proteinuria

2004 ◽  
Vol 95 (3) ◽  
pp. c77-c83 ◽  
Author(s):  
Sonia Athena Karabina ◽  
Haralampos Pappas ◽  
George Miltiadous ◽  
Eleni Bairaktari ◽  
Dimitris Christides ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Heavy Proteinuria

scholarly journals Low-density lipoprotein clearance in patients with chronic renal failure

2009 ◽  
Vol 24 (7) ◽  
pp. 2131-2135 ◽  
Author(s):  
Helena Kastarinen ◽  
Sohvi Hörkkö ◽  
Heikki Kauma ◽  
Anna Karjalainen ◽  
Markku J. Savolainen ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density

Influence of intermediate-density lipoproteins on the accuracy of the Friedewald formula

1991 ◽  
Vol 37 (8) ◽  
pp. 1394-1397 ◽  
Author(s):  
M Sentí ◽  
J Pedro-Botet ◽  
X Nogués ◽  
J Rubiés-Prat
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Percentage Error ◽  
Control Group ◽  
Low Density ◽  
The Mean ◽  
Friedewald Formula ◽  
Intermediate Density

Abstract Values of low-density lipoprotein (LDL) cholesterol (C) according to the Friedewald formula (Clin Chem 1972;18:499-502) were compared with those obtained by lipoprotein fractionation in 98 healthy subjects (control group), 135 specimens from patients with peripheral vascular and cerebrovascular disease (atherosclerotic group), and 45 with chronic renal failure on hemodialysis (CRF group). All had concentrations of total cholesterol between 3.23 and 7.76 mmol/L (1.25-3.00 g/L) and triglycerides less than 3.39 mmol/L (less than 3.00 g/L). The percentage error of calculated LDL-C was 4% in controls with a cholesterol/triglycerides (C/TG) ratio for very-low-density lipoprotein (VLDL) of 0.20, but greater than 60% in those with a (C/TG)VLDL ratio of 0.40. The percentage of error in sera of patients with atherosclerosis and chronic renal failure was higher than in controls with a similar mean (C/TG)VLDL ratio. The percentage of error of calculated LDL-C increases progressively with the increase in the C/TG intermediate-density lipoprotein (IDL) ratio, both in controls and in the atherosclerotic and CRF groups. Similar findings are observed when the mean percentage of error of measured LDL-C is evaluated. The percentage of error from calculated LDL-C in the atherosclerotic and CRF groups is significantly lower than that obtained by comparison of LDL-C separated by ultracentrifugation when the "broad cut" LDL (IDL plus LDL, both by ultracentrifugation) was used. The high percentage of errors found in the groups of patients studied underlines the need for caution when assessing the reliability of the Friedewald formula, particularly in cases in which disturbances in IDL composition are suspected.

scholarly journals Decreased clearance of low-density lipoprotein in patients with chronic renal failure

1994 ◽  
Vol 45 (2) ◽  
pp. 561-570 ◽  
Author(s):  
Sohvi Hörkkö ◽  
Kaisa Huttunen ◽  
Taina Korhonen ◽  
Y. Antero Kesäniemi
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density

Low-density lipoprotein oxidizability in children with chronic renal failure

2008 ◽  
Vol 50 (4) ◽  
pp. 447-453
Author(s):  
Lorenzo Iughetti ◽  
Cristina Perugini ◽  
Barbara Predieri ◽  
Simona Madeo ◽  
Giorgio Bellomo ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density

Dyslipidemia of chronic renal failure: the nature, mechanisms, and potential consequences

2006 ◽  
Vol 290 (2) ◽  
pp. F262-F272 ◽  
Author(s):  
N. D. Vaziri
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Hepatic Lipase ◽  
Low Density Lipoprotein ◽  
Plasma Concentrations ◽  
Cholesterol Acyltransferase ◽  
Lipoprotein Metabolism ◽  
Density Lipoprotein ◽  
Triglyceride Rich Lipoprotein ◽  
Density Lipoprotein Receptor

Chronic renal failure (CRF) results in profound lipid disorders, which stem largely from dysregulation of high-density lipoprotein (HDL) and triglyceride-rich lipoprotein metabolism. Specifically, maturation of HDL is impaired and its composition is altered in CRF. In addition, clearance of triglyceride-rich lipoproteins and their atherogenic remnants is impaired, their composition is altered, and their plasma concentrations are elevated in CRF. Impaired maturation of HDL in CRF is primarily due to downregulation of lecithin-cholesterol acyltransferase (LCAT) and, to a lesser extent, increased plasma cholesteryl ester transfer protein (CETP). Triglyceride enrichment of HDL in CRF is primarily due to hepatic lipase deficiency and elevated CETP activity. The CRF-induced hypertriglyceridemia, abnormal composition, and impaired clearance of triglyceride-rich lipoproteins and their remnants are primarily due to downregulation of lipoprotein lipase, hepatic lipase, and the very-low-density lipoprotein receptor, as well as, upregulation of hepatic acyl-CoA cholesterol acyltransferase (ACAT). In addition, impaired HDL metabolism contributes to the disturbances of triglyceride-rich lipoprotein metabolism. These abnormalities are compounded by downregulation of apolipoproteins apoA-I, apoA-II, and apoC-II in CRF. Together, these abnormalities may contribute to the risk of arteriosclerotic cardiovascular disease and may adversely affect progression of renal disease and energy metabolism in CRF.

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