scholarly journals Cosegregation of Robertsonian metacentric chromosomes in the first meiotic division of multiple heterozygous male mice as revealed by FISH analysis of spermatocyte II metaphases

2003 ◽  
Vol 101 (2) ◽  
pp. 136-142 ◽  
Author(s):  
M. Scascitelli ◽  
F. Pacchierotti ◽  
M. Rizzoni ◽  
B. Gustavino ◽  
F. Spirito
Keyword(s):  
Meiotic Division ◽  
Fish Analysis ◽  
Male Mice ◽  
Heterozygous Male

The frequency of heterologous synapsis increases with aging in Robertsonian heterozygous male mice

2012 ◽  
Vol 20 (2) ◽  
pp. 269-278 ◽  
Author(s):  
Chiara Vasco ◽  
Marcia Manterola ◽  
Jesus Page ◽  
Maurizio Zuccotti ◽  
Roberto de la Fuente ◽  
...  
Keyword(s):  
Male Mice ◽  
Heterozygous Male

Effects of Streptozotocin and Alloxan on Granular Tubules of Male Mouse Submandibular Gland

1981 ◽  
Vol 39 ◽  
pp. 596-597
Author(s):  
A. M. deCamargo ◽  
J.S. Hanker ◽  
W.W. Ambrose ◽  
WF. Hilton ◽  
B.L. Giammara
Keyword(s):  
Diabetes Mellitus ◽  
Sexual Dimorphism ◽  
Submandibular Gland ◽  
Male Mouse ◽  
Spontaneous Diabetes ◽  
Insulin Deficiency ◽  
Male Mice ◽  
Heterozygous Male ◽  
Causative Factors ◽  
Human Diabetes

Diabetogenic agents can be conveniently classified into simple chemicals and complex hormones. Streptozotocin and alloxan are diabetogenic chemicals which cause a permanent diabetes by destruction of the B cells of the islets of Langerhans of the pancreas and a resulting insulin deficiency. The diabetogenic chemicals, however, may also have sex hormone-like actions which could be contributory or even causative factors in diabetes mellitus.Circulating androgens have long been known to effect a sexual dimorphism of the submandibular gland,and spontaneous diabetes markedly affects the development of the submandibular glands of mice. The effects of alloxan on the submandibular gland of male mice has previously been reported.In the present study, the effects of streptozotocin, a diabetogenic agent widely employed in cancer chemotherapy, were investigated in heterozygous male mice of the C57BI, Ksj db strain whose homozygous littermates are afflicted with a syndrome resembling maturity-onset human diabetes mellitus.

scholarly journals Non-Mendelian inheritance during inbreeding of Cav3.2 and Cav2.3 deficient mice

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Serdar Alpdogan ◽  
Renate Clemens ◽  
Jürgen Hescheler ◽  
Felix Neumaier ◽  
Toni Schneider
Keyword(s):  
Prenatal Development ◽  
Mendelian Inheritance ◽  
Genotype Distribution ◽  
Male Mice ◽  
Epileptic Encephalopathies ◽  
Voltage Gated ◽  
Female Mice ◽  
Heterozygous Male ◽  
Deficient Mice

Abstract The mating of 77 heterozygous pairs (Cav3.2[+|−] x Cav3.2[+|−]) revealed a significant deviation of genotype distribution from Mendelian inheritance in weaned pups. The mating of 14 pairs (Cav3.2[−|−] female x Cav3.2[+|−] male) and 8 pairs (Cav3.2[+|−] female x Cav3.2[−|−] male) confirmed the significant reduction of deficient homozygous Cav3.2[−|−] pups, leading to the conclusion that prenatal lethality may occur, when one or both alleles, encoding the Cav3.2T-type Ca2+ channel, are missing. Also, the mating of 63 heterozygous pairs (Cav2.3[+|−] x Cav2.3[+|−]) revealed a significant deviation of genotype distribution from Mendelian inheritance in weaned pups, but only for heterozygous male mice, leading to the conclusion that compensation may only occur for Cav2.3[−|−] male mice lacking both alleles of the R-type Ca2+ channel. During the mating of heterozygous parents, the number of female mice within the weaned population does not deviate from the expected Mendelian inheritance. During prenatal development, both, T- and R-type Ca2+ currents are higher expressed in some tissues than postnatally. It will be discussed that the function of voltage-gated Ca2+ channels during prenatal development must be investigated in more detail, not least to understand devastative diseases like developmental epileptic encephalopathies (DEE).

Ultrastructural Lesions Produced by Alcohol and Sucrose in the Heart and Liver of C57BL Mice

1970 ◽  
Vol 28 ◽  
pp. 208-209
Author(s):  
K.K. SEKHRI ◽  
C.S. ALEXANDER ◽  
H.T. NAGASAWA
Keyword(s):  
Osmium Tetroxide ◽  
Male Mice ◽  
Alcohol Group ◽  
Group Iii ◽  
Group I ◽  
C57bl Mice ◽  
Group Ii

C57BL male mice (Jackson Lab., Bar Harbor, Maine) weighing about 18 gms were randomly divided into three groups: group I was fed sweetened liquid alcohol diet (modified Schenkl) in which 36% of the calories were derived from alcohol; group II was maintained on a similar diet but alcohol was isocalorically substituted by sucrose; group III was fed regular mouse chow ad lib for five months. Liver and heart tissues were fixed in 2.5% cacodylate buffered glutaraldehyde, post-fixed in 2% osmium tetroxide and embedded in Epon-araldite.

1859: The Histone Deycetylase Inhibitor Trichostatin-a Arrests Meiosis in Male Mice

2007 ◽  
Vol 177 (4S) ◽  
pp. 617-617
Author(s):  
Klaus Steger ◽  
Irina Fenic ◽  
Hamid M. Hossain ◽  
Violetta Sonnack ◽  
Svetlin Tchatalbachev ◽  
...  
Keyword(s):  
Trichostatin A ◽  
Male Mice

1625: Role of Estrogen Receptor β in the Regulation of Sexual Behavior in Male Mice

2004 ◽  
Vol 171 (4S) ◽  
pp. 429-429
Author(s):  
Masayoshi Nomura ◽  
Naohiro Fujimoto ◽  
Donald W. Pfaff ◽  
Sonoko Ogawa ◽  
Tetsuro Matsumoto
Keyword(s):  
Estrogen Receptor ◽  
Sexual Behavior ◽  
Estrogen Receptor Β ◽  
Male Mice

Author response for "Enriched environment enhances NK cell maturation through hypothalamic BDNF in male mice"

2020 ◽  
Author(s):  
Anthony G. Mansour ◽  
Run Xiao ◽  
Stephen M Bergin ◽  
Wei Huang ◽  
Logan A. Chrislip ◽  
...  
Keyword(s):  
Nk Cell ◽  
Enriched Environment ◽  
Cell Maturation ◽  
Author Response ◽  
Male Mice
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