Clearance of Necrobiosis lipoidica with Fumaric Acid Esters

Dermatology ◽  
2003 ◽  
Vol 207 (4) ◽  
pp. 422-424 ◽  
Author(s):  
T. Gambichler ◽  
A. Kreuter ◽  
M. Freitag ◽  
F.M. Pawlak ◽  
N.H. Brockmeyer ◽  
...  
Keyword(s):  
Fumaric Acid ◽  
Necrobiosis Lipoidica ◽  
Fumaric Acid Esters ◽  
Acid Esters

Fumaric acid esters in necrobiosis lipoidica: results of a prospective noncontrolled study

2005 ◽  
Vol 153 (4) ◽  
pp. 802-807 ◽  
Author(s):  
A. Kreuter ◽  
C. Knierim ◽  
M. Stucker ◽  
F. Pawlak ◽  
S. Rotterdam ◽  
...  
Keyword(s):  
Fumaric Acid ◽  
Necrobiosis Lipoidica ◽  
Fumaric Acid Esters ◽  
Acid Esters

Comorbidity and Therapeutic Approaches in Patients with Necrobiosis Lipoidica

Dermatology ◽  
2021 ◽  
pp. 1-8
Author(s):  
Cornelia Erfurt-Berge ◽  
Veronika Heusinger ◽  
Finja Reinboldt-Jockenhöfer ◽  
Joachim Dissemond ◽  
Regina Renner
Keyword(s):  
Fumaric Acid ◽  
Calcineurin Inhibitors ◽  
Compression Therapy ◽  
Topical Steroids ◽  
Necrobiosis Lipoidica ◽  
Therapeutic Approaches ◽  
Fumaric Acid Esters ◽  
Topical Calcineurin Inhibitors ◽  
Randomized Controlled Studies ◽  
Acid Esters

<b><i>Background:</i></b> Necrobiosis lipoidica (NL) is a rare granulomatous disorder of unknown aetiology. Randomized controlled studies are not available due to it being an orphan disease. <b><i>Objectives:</i></b> We evaluated patients in 2 dermatological centres to cluster data about epidemiology, the therapeutic approaches for NL, and their efficacy. <b><i>Materials and Methods:</i></b> Comorbidity and the efficacy of the applied treatment was assessed for 98 patients. <b><i>Results:</i></b> We identified 54% of patients with concomitant diabetes and 19% with thyroidal disorders. Topical steroids (85.7%) were predominantly used followed by calcineurin inhibitors (31%) and phototherapy (41.8%). Systemically, fumaric acid esters were more frequently applied (26.8%) than steroids (24.4%) and dapsone (24.4%). Steroids, compression therapy, calcineurin inhibitors, phototherapy, fumaric acid esters, and dapsone showed remarkable efficacy. <b><i>Conclusion:</i></b> Therapeutic options were chosen individually in accordance with the severity of NL and presence of ulceration. Topical calcineurin inhibitors, systemic application of fumaric acid esters, and dapsone represent effective alternatives to the use of steroids.

scholarly journals Successful treatment of recalcitrant cutaneous sarcoidosis with fumaric acid esters

2002 ◽  
Vol 2 (1) ◽  
Author(s):  
Ute Nowack ◽  
Thilo Gambichler ◽  
Christoph Hanefeld ◽  
Ulrike Kastner ◽  
Peter Altmeyer
Keyword(s):  
Successful Treatment ◽  
Fumaric Acid ◽  
Cutaneous Sarcoidosis ◽  
Fumaric Acid Esters ◽  
Acid Esters

Fumaric acid esters in psoriasis and multiple sclerosis

2014 ◽  
Vol 39 (4) ◽  
pp. 488-491 ◽  
Author(s):  
C. Zecca ◽  
M. Caporro ◽  
M. Adami ◽  
C. Mainetti ◽  
C. Gobbi
Keyword(s):  
Multiple Sclerosis ◽  
Fumaric Acid ◽  
Fumaric Acid Esters ◽  
Acid Esters

Fumaric acid esters for severe psoriasis: a retrospective review of 58 cases

2005 ◽  
Vol 153 (3) ◽  
pp. 549-551 ◽  
Author(s):  
M.J. Harries ◽  
R.J.G. Chalmers ◽  
C.E.M. Griffiths
Keyword(s):  
Fumaric Acid ◽  
Retrospective Review ◽  
Severe Psoriasis ◽  
Fumaric Acid Esters ◽  
Acid Esters
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