Diagnostic Procedures in Endocrine Disorders of Sodium Regulation

In order to establish patterns and coping strategies in relation to the nosogenic factors of psychotraumatization among the patients with psychoendocrine syndrome on the background of metabolic disorders of the thyroid gland, adrenal cortex and hypogonadism, at the Ukrainian Scientific and Practical Center for Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine, 400 patients with the indicated forms of endocrine disorders were examined. The study was conducted with the introduction of the psychodiagnostic method and the Lazarus copying test was used in the study of group comparison. Coping patterns were studied in relation to such factors: the formation of functional and morphological disorders, the presence of a chronic disease, physical activity restrictions, the presence of severely experienced symptoms of the disease, the need for treatment with drugs that have side effects, which adversely affect the state, cancerophobic experience, introspective cognitive and mental disorders, the need for diagnostic procedures and therapeutic measures with high cost, presence of labor restrictions which causes financial difficulties and loss of economically dominant role in the family, limiting the circle of communication, is associated with the presence of the disease or its symptoms, the need to follow a diet, refusal from alcohol and any stimulating substances, and dependence on hormone replacement therapy.

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Tumor Diagnosis

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100053966 ◽

1982 ◽

Vol 40 ◽

pp. 262-265

Author(s):

Bruce Mackay

Keyword(s):

Electron Microscopy ◽

Transmission Electron Microscopy ◽

Differential Diagnosis ◽

Light Microscopy ◽

Clinical Examination ◽

Ultrastructural Study ◽

Diagnostic Procedures ◽

Specific Diagnosis ◽

Transmission Electron ◽

Microscopic Diagnosis

The broadest application of transmission electron microscopy (EM) in diagnostic medicine is the identification of tumors that cannot be classified by routine light microscopy. EM is useful in the evaluation of approximately 10% of human neoplasms, but the extent of its contribution varies considerably. It may provide a specific diagnosis that can not be reached by other means, but in contrast, the information obtained from ultrastructural study of some 10% of tumors does not significantly add to that available from light microscopy. Most cases fall somewhere between these two extremes: EM may correct a light microscopic diagnosis, or serve to narrow a differential diagnosis by excluding some of the possibilities considered by light microscopy. It is particularly important to correlate the EM findings with data from light microscopy, clinical examination, and other diagnostic procedures.

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Melatonin as a sedation substitute for diagnostic procedures

Developmental Medicine & Child Neurology ◽

10.1017/s0012162200221191 ◽

2000 ◽

Vol 42 (9) ◽

pp. 646-647 ◽

Cited By ~ 4

Author(s):

Hilary Espezel ◽

Carolyn Graves ◽

James E Jan ◽

Anton Miller ◽

Karin Renner ◽

...

Keyword(s):

Diagnostic Procedures

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Special Diagnostic Procedures in Sports Medicine

Clinics in Sports Medicine ◽

10.1016/s0278-5919(20)30813-9 ◽

1989 ◽

Vol 8 (3) ◽

pp. 517-540

Author(s):

George H. Belhobek ◽

Bradford J. Richmond ◽

David W. Piraino ◽

Harris Freed

Keyword(s):

Sports Medicine ◽

Diagnostic Procedures

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Impact of COVID-19 on Nuclear Medicine in Germany, Austria and Switzerland: An International Survey in April 2020

Nuklearmedizin ◽

10.1055/a-1163-3096 ◽

2020 ◽

Vol 59 (04) ◽

pp. 294-299 ◽

Cited By ~ 4

Author(s):

Lutz S. Freudenberg ◽

Ulf Dittmer ◽

Ken Herrmann

Keyword(s):

Nuclear Medicine ◽

Health Systems ◽

Personal Protective Equipment ◽

Large Scale ◽

Diagnostic Procedures ◽

Protective Equipment ◽

Current Crisis ◽

Web Based ◽

Public Versus Private ◽

The Impact

Abstract Introduction Preparations of health systems to accommodate large number of severely ill COVID-19 patients in March/April 2020 has a significant impact on nuclear medicine departments. Materials and Methods A web-based questionnaire was designed to differentiate the impact of the pandemic on inpatient and outpatient nuclear medicine operations and on public versus private health systems, respectively. Questions were addressing the following issues: impact on nuclear medicine diagnostics and therapy, use of recommendations, personal protective equipment, and organizational adaptations. The survey was available for 6 days and closed on April 20, 2020. Results 113 complete responses were recorded. Nearly all participants (97 %) report a decline of nuclear medicine diagnostic procedures. The mean reduction in the last three weeks for PET/CT, scintigraphies of bone, myocardium, lung thyroid, sentinel lymph-node are –14.4 %, –47.2 %, –47.5 %, –40.7 %, –58.4 %, and –25.2 % respectively. Furthermore, 76 % of the participants report a reduction in therapies especially for benign thyroid disease (-41.8 %) and radiosynoviorthesis (–53.8 %) while tumor therapies remained mainly stable. 48 % of the participants report a shortage of personal protective equipment. Conclusions Nuclear medicine services are notably reduced 3 weeks after the SARS-CoV-2 pandemic reached Germany, Austria and Switzerland on a large scale. We must be aware that the current crisis will also have a significant economic impact on the healthcare system. As the survey cannot adapt to daily dynamic changes in priorities, it serves as a first snapshot requiring follow-up studies and comparisons with other countries and regions.

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Assessment of endocrine disorders of the hypothalamicpituitary axis by nuclear medicine techniques

Nuklearmedizin ◽

10.1055/s-0038-1625645 ◽

2002 ◽

Vol 41 (02) ◽

pp. 80-90 ◽

Cited By ~ 2

Author(s):

F. Jockenhövel ◽

P. Theissen ◽

M. Dietlein ◽

W. Krone ◽

H. Schicha ◽

...

Keyword(s):

Nuclear Medicine ◽

Pituitary Adenomas ◽

Dopamine D2 Receptor ◽

Somatostatin Receptor ◽

D2 Receptor ◽

Ectopic Acth Syndrome ◽

Endocrine Disorders ◽

Ectopic Acth ◽

Number Of Patients ◽

Hypothalamic Pituitary Axis

SummaryThe following article reviews nuclear medicine techniques which can be used for assessment of endocrine disorders of the hypothalamic-pituitary axis. For planar and SPECT imaging somatostatin-receptor- and dopamine- D2-receptor-scintigraphy are the most widely distributed techniques. These nuclear medicine techniques may be indicated in selected cases to answer differential diagnostic problems. They can be helpful to search for presence and localization of receptor positive tissue. Furthermore they can detect metastasis in the rare cases of a pituitary carcinoma. Scintigraphy with Gallium-67 is suitable for further diagnostic evaluation in suspected hypophysitis. Other SPECT radiopharmaca do not have relevant clinical significance. F-18-FDG as PET radiopharmacon is not ideal because obvious pituitary adenomas could not be visualized. Other PET radiopharmaca including C-11-methionine, C-11-tyrosine, F-18-fluoroethylspiperone, C-11-methylspiperone, and C-11-raclopride are available in specialized centers only. Overall indications for nuclear medicine in studies for the assessment of endocrine disorders of the hypothalamic-pituitary-axis are rare. Original studies often report only about a small number of patients. According to the authors’ opinion the relevance of nuclear medicine in studies of clinically important endocrinologic fields, e. g. localization of small ACTH-producing pituitary adenomas, tumor localization in ectopic ACTH syndrome, localization of recurrent pituitary tissue, assessment of small incidentalomas, can not be definitely given yet.

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Immunszintigraphie mit 111ln-DTPA-markierten monoklonalen Antikörpern: Vergleich zwischen ECT und planarer Szintigraphie

Nuklearmedizin ◽

10.1055/s-0038-1628900 ◽

1987 ◽

Vol 26 (06) ◽

pp. 258-262

Author(s):

J. Happi ◽

R. P. Baum ◽

J. Frohn ◽

B. Weimer ◽

A. Halbsguth ◽

...

Keyword(s):

Imaging Techniques ◽

Diagnostic Procedures ◽

Undifferentiated Carcinoma ◽

Whole Body ◽

Acquisition Time ◽

Planar Imaging ◽

Primary Tumors ◽

Intraindividual Comparison ◽

Single Detector ◽

Increased Sensitivity

The present study was done in order to examine if the use of111ln-DTPA- labeled MAb fragments in place of 131l-labeled MAb fragments increases the sensitivity of tomographic immunoscintigraphy to reach the level of that of planar imaging techniques. In 11 patients with various primary tumors, local recurrences or metastases [colorectal carcinoma (n = 7), ovarian carcinoma (n = 2), papillary thyroid carcinoma (n = 1), undifferentiated carcinoma of the lung (n = 1)], immunoscintigraphy (IS) was carried out using 111ln-DTPA- labeled F(ab’)2 fragments of various MAbs (anti-CEA, OC 125, anti-hTG) and planar and tomographic imaging were compared intraindividually. By conventional diagnostic procedures, the presence of a tumor mass was confirmed (transmission computer tomography, ultrasound) or verified (131l whole-body scintigraphy, histology) in all cases. Immunoscintigraphy was positive in 9 out of 11 cases by ECT and in 10 out of 11 cases by planar imaging. When using 111 In-labeled MAb fragments, intraindividual comparison of ECT and planar imaging resulted in a similar sensitivity. The increased sensitivity of ECT using this tracer in contrast to 131l-labeled MAb fragments may be attributed to the fact that the physical properties of111 In are much more suitable for the gamma cameras most commonly used (single detector, 3/8” crystal); using 111 In-labeled MAb fragments, count rates sufficient for ECT can be obtained within a reasonable acquisition time. This allows to combine IS with the advantages of ECT regarding tumour localization and prevention of artefacts due to superposition of background.

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Pattern Recognition in Histo-Pathology: Basic Considerations

Methods of Information in Medicine ◽

10.1055/s-0038-1635387 ◽

1982 ◽

Vol 21 (01) ◽

pp. 15-22 ◽

Cited By ~ 10

Author(s):

W. Schlegel ◽

K. Kayser

Keyword(s):

Pattern Recognition ◽

Graph Theory ◽

Normal Tissue ◽

Diagnostic Procedures ◽

Minimal Distance ◽

Malignant Growth ◽

Colon Tissue ◽

First Results ◽

Tissue Structures ◽

The Given

A basic concept for the automatic diagnosis of histo-pathological specimen is presented. The algorithm is based on tissue structures of the original organ. Low power magnification was used to inspect the specimens. The form of the given tissue structures, e. g. diameter, distance, shape factor and number of neighbours, is measured. Graph theory is applied by using the center of structures as vertices and the shortest connection of neighbours as edges. The algorithm leads to two independent sets of parameters which can be used for diagnostic procedures. First results with colon tissue show significant differences between normal tissue, benign and malignant growth. Polyps form glands that are twice as wide as normal and carcinomatous tissue. Carcinomas can be separated by the minimal distance of the glands formed. First results of pattern recognition using graph theory are discussed.

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