scholarly journals Coagulation Factors and Tumor Cell Biology: The Role of Tissue Factor

2003 ◽  
Vol 33 (1) ◽  
pp. 22-25 ◽  
Author(s):  
Maria Benedetta Donati ◽  
Roberto Lorenzet
Keyword(s):  
Tumor Cell ◽  
Tissue Factor ◽  
Cell Biology ◽  
Coagulation Factors ◽  
Tumor Cell Biology

scholarly journals The emerging role of paraptosis in tumor cell biology: Perspectives for cancer prevention and therapy with natural compounds

2020 ◽  
Vol 1873 (2) ◽  
pp. 188338 ◽  
Author(s):  
Fabrizio Fontana ◽  
Michela Raimondi ◽  
Monica Marzagalli ◽  
Alessandro Di Domizio ◽  
Patrizia Limonta
Keyword(s):  
Tumor Cell ◽  
Cancer Prevention ◽  
Cell Biology ◽  
Natural Compounds ◽  
Tumor Cell Biology ◽  
Prevention And Therapy

Role of full-length osteoprotegerin in tumor cell biology

2008 ◽  
Vol 66 (5) ◽  
pp. 841-851 ◽  
Author(s):  
G. Zauli ◽  
E. Melloni ◽  
S. Capitani ◽  
P. Secchiero
Keyword(s):  
Tumor Cell ◽  
Cell Biology ◽  
Full Length ◽  
Tumor Cell Biology

Studies in Tumor Cell Biology

2018 ◽  
pp. 103-116
Author(s):  
Simon P. Langdon ◽  
John F. Smyth
Keyword(s):  
Tumor Cell ◽  
Cell Biology ◽  
Tumor Cell Biology

Reductive Stress, Bioactive Compounds, Redox-Active Metals, and Dormant Tumor Cell Biology to Develop Redox-Based Tools for the Treatment of Cancer

2020 ◽  
Vol 33 (12) ◽  
pp. 860-881 ◽  
Author(s):  
José L. Quiles ◽  
Cristina Sánchez-González ◽  
Laura Vera-Ramírez ◽  
Francesca Giampieri ◽  
M. Dolores Navarro-Hortal ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Bioactive Compounds ◽  
Cell Biology ◽  
Reductive Stress ◽  
Redox Active ◽  
Tumor Cell Biology

Anterior gradient 2: A novel player in tumor cell biology

2011 ◽  
Vol 304 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Veronika Brychtova ◽  
Borivoj Vojtesek ◽  
Roman Hrstka
Keyword(s):  
Tumor Cell ◽  
Cell Biology ◽  
Tumor Cell Biology

P97/CDC-48: Proteostasis control in tumor cell biology

2013 ◽  
Vol 337 (1) ◽  
pp. 26-34 ◽  
Author(s):  
Delphine Fessart ◽  
Esther Marza ◽  
Saïd Taouji ◽  
Frédéric Delom ◽  
Eric Chevet
Keyword(s):  
Tumor Cell ◽  
Cell Biology ◽  
Tumor Cell Biology

The Concentration of Exogenously Added Lipids and Endogenously Available Microparticles Are Major Determinants of Thrombin Generation in Plasma.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 4000-4000
Author(s):  
C. Kluft ◽  
P. Meijer ◽  
R. Kret ◽  
V. Kaufmann ◽  
J. Mager
Keyword(s):  
Tissue Factor ◽  
Thrombin Generation ◽  
Area Under The Curve ◽  
Coagulation Factors ◽  
Factor Ix ◽  
Fixed Amount ◽  
High Lipid ◽  
Factor Ii ◽  
The Difference

Abstract Thrombin generation tests are started by adding coagulation activator (e.g. tissue factor or contact activator) together with lipids. We evaluated the role of lipids in tests started with a fixed amount of tissue factor (7.16 pM) and addition of either 3.2 (high) or 0.32 (low) μM of lipids (Technothrombin ® TGA assays from Technoclone, Vienna) in both normal plasma and plasma that was ultracentrifuged (30 minutes at 15,000 g) to remove microparticles (MPs). The tests were performed in plasma samples of groups of apparently healthy individuals. It was observed in 54 healthy volunteers that starting with high or low lipids substantially influenced the total amount of thrombin generated expressed by the area under the curve (AUC) (AUC median 2492, IQR 716 versus AUC median 1154, IQR 652 nM*min, respectively), the rate of thrombin formation or velocity index (VI) (median 53.4, IQR 43.6 and median 11.7, IQR 10.6 nM/min, respectively), and the lag time to the start of thrombin generation (median 10.3, IQR 2.4 versus median 17.5, IQR 5.0 minutes, respectively). It can be concluded that the VI is the most sensitive variable showing approximately a factor of 5 difference between high and low lipid. The difference of adding high or low lipid on VI was primarily dependent upon the lipid concentration and to a limited extend influenced (univariate) by factor II levels (12%) and factor IX levels (10 %), taking into account practically all known coagulation factors (fibrinogen, II, V, VII, VIII, IX, X, XI, XII, PC, PS, PZ, TFPI, PCI) determined in the 54 plasma’s as potential determinant. In plasma of 36 volunteers microparticles were removed and VI dropped to 19% in comparison to the untreated plasma when tested with the addition of high lipid and to 3.1% with the addition of low lipid. Re-addition of MPs to a specific plasma restored VI dose dependently with an optimum at 2x104 MPs/ml. The same level of VI (63.8 and 62.0 nM/min, respectively) was reached with high and low lipid addition when 2.104 MPs/ml were added. It is concluded that endogenous MPs play an important role in thrombin generation tests, in particular but not exclusively when the test is performed with low levels of added lipids.

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