Role of Thyroid Hormones on the Synthesis and Release of Atrial Natriuretic Peptide in Rats with Acute Renal Failure

2004 ◽  
Vol 95 (1) ◽  
pp. e24-e29
Author(s):  
Ernesto Rodríguez ◽  
Ana María García ◽  
Enrique Foyo ◽  
Dante Amato ◽  
Ramón Paniagua
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Atrial Natriuretic Peptide ◽  
Thyroid Hormones ◽  
Natriuretic Peptide ◽  
Atrial Natriuretic

scholarly journals Effects of atrial natriuretic peptide in clinical acute renal failure

1994 ◽  
Vol 45 (6) ◽  
pp. 1731-1738 ◽  
Author(s):  
S. Noor Rahman ◽  
Grace E. Kim ◽  
Alan S. Mathew ◽  
Carol A. Goldberg ◽  
Robin Allgren ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Atrial Natriuretic

The atrial natriuretic peptide- and catecholamine-induced lipolysis and expression of related genes in adipose tissue in hypothyroid and hyperthyroid patients

2007 ◽  
Vol 293 (1) ◽  
pp. E246-E251 ◽  
Author(s):  
J. Polak ◽  
C. Moro ◽  
E. Klimcakova ◽  
M. Kovacikova ◽  
M. Bajzova ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Atrial Natriuretic Peptide ◽  
Thyroid Hormones ◽  
Natriuretic Peptide ◽  
Hormone Sensitive Lipase ◽  
Hormone Sensitive ◽  
Hyperthyroid Patients ◽  
Atrial Natriuretic

Thyroid dysfunction is associated with several abnormalities in intermediary metabolism, including impairment of lipolytic response to catecholamines in subcutaneous abdominal adipose tissue (SCAAT). Atrial natriuretic peptide (ANP) is a powerful lipolytic peptide; however, the role of ANP-mediated lipolysis in thyroid disease has not been elucidated. The aim of this study was to investigate the role of thyroid hormones in the regulation of ANP-induced lipolysis as well as in the gene expression of hormone-sensitive lipase, phosphodiesterase 3B (PDE3B), uncoupling protein-2 (UCP2), natriuretic peptide receptor type A, and β2-adrenergic receptor in SCAAT of hyperthyroid and hypothyroid patients. Gene expression in SCAAT was studied in 13 hypothyroid and 11 hyperthyroid age-matched women before and 2–4 mo after the normalization of their thyroid status. A microdialysis study was performed on a subset of nine hyperthyroid and 10 hypothyroid subjects. ANP- and isoprenaline-induced lipolyses were higher in hyperthyroid subjects, with no differences between the groups following treatment. Hormone-sensitive lipase gene expression was higher in hyperthyroid compared with hypothyroid subjects before treatment, whereas no difference was observed following treatment. No differences in gene expression of other genes were observed between the two groups. Following treatment, the gene expression of UCP2 decreased in hyperthyroid, whereas the expression of PDE3B decreased in hypothyroid subjects. We conclude that thyroid hormones regulate ANP- and isoprenaline-mediated lipolysis in human SCAAT in vivo. Increased lipolytic subcutaneous adipose tissue response in hyperthyroid patients may involve postreceptor signaling mechanisms.

scholarly journals Atrial natriuretic peptide and dopamine in a rat model of ischemic acute renal failure

1989 ◽  
Vol 35 (5) ◽  
pp. 1126-1132 ◽  
Author(s):  
John D. Conger ◽  
Sandor A. Falk ◽  
Brad H. Yuan ◽  
Robert W. Schrier
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Rat Model ◽  
Ischemic Acute Renal Failure ◽  
Atrial Natriuretic

scholarly journals Role of atrial natriuretic peptide in experimental renal failure.

1988 ◽  
Vol 52 (12) ◽  
pp. 1441-1445 ◽  
Author(s):  
TSUTOMU SANAKA ◽  
KEN TSUCHIYA ◽  
KOSAKU NITTA ◽  
MASAYOSHI SONE ◽  
NOBUHIRO SUGINO
Keyword(s):  
Renal Failure ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Experimental Renal Failure ◽  
Atrial Natriuretic

Atrial natriuretic peptide and verapamil can prevent gentamicin induced acute renal failure in the rat

Nephrology ◽  
1995 ◽  
Vol 1 (3) ◽  
pp. 241-250 ◽  
Author(s):  
Lothar SCHRAMM ◽  
Josef ZIMMERMANN ◽  
Kai LOPAU ◽  
Hong LING ◽  
Joachim HARLOS ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Atrial Natriuretic
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