Comparison of Final Height in Monozygotic Twins, One with Idiopathic and Isolated Growth Hormone Deficiency Treated with Low Dose of Growth Hormone

2003 ◽  
Vol 60 (3) ◽  
pp. 152-155 ◽  
Author(s):  
Hirokazu Sato ◽  
Shigeki Miyamoto ◽  
Hiromasa Noda ◽  
Nozomu Sasaki
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Low Dose ◽  
Final Height ◽  
Monozygotic Twins ◽  
Hormone Deficiency ◽  
Isolated Growth Hormone Deficiency

The effects of treatment combining an agonist of gonadotropin-releasing hormone with growth hormone in pubertal patients with isolated growth hormone deficiency

1989 ◽  
Vol 120 (6) ◽  
pp. 795-799 ◽  
Author(s):  
Jean Edmond Toublanc ◽  
Claire Couprie ◽  
Philippe Garnier ◽  
Jean-Claude Job
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Final Height ◽  
Bone Age ◽  
Hormone Deficiency ◽  
Gnrh Analogue ◽  
Isolated Growth Hormone Deficiency ◽  
One Year ◽  
Long Acting

Abstract. The final height of patients treated with growth hormone for isolated growth hormone deficiency has, up to now, been subnormal, with a mean below −2 sd in the series reported, an insufficient height at the onset of puberty and a more or less accelerated bone maturation during puberty being two important factors of the poor results. A long-acting analogue of gonadoliberin, Trp6-GnRH, has been given to GH-treated patients with isolated growth hormone deficiency at the time they reached pubertal stage 2, in combination with unchanged doses of GH, for one year in 11 and for two years in 7 of them. It resulted in an increase in the height age/bone age ratio and a reduction of the height insufficiency for bone age. The increase was slight but significant after one year, and fair after two years, in spite of a reduced annual growth rate. Post-analogue follow-up in 5 patients with continued GH treatment showed a good development of growth and of puberty. It is concluded that combination of the long-acting Trp6-GnRH analogue and GH for 1–2 years in patients with isolated growth hormone deficiency whose puberty starts with a very insufficient height may be an appropriate way to improve their growth parameters. Studies with increased doses of GH or increased frequency of injections could help to optimize the results. Several years of follow-up are needed for demonstrating the results on final height.

TYPICAL CASES OF ISOLATED GROWTH HORMONE DEFICIENCY WITH AUTOSOMAL RECESSIVE INHERITANCE

1970 ◽  
Vol 63 (4) ◽  
pp. 618-624 ◽  
Author(s):  
Y. Kumahara ◽  
Y. Okada ◽  
K. Miyai ◽  
H. Iwatsubo
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Autosomal Recessive ◽  
Autosomal Recessive Inheritance ◽  
Adult Subject ◽  
Hormone Deficiency ◽  
Recessive Inheritance ◽  
Arginine Infusion ◽  
Isolated Growth Hormone Deficiency ◽  
Male Dwarf

ABSTRACT A 25-year-old male dwarf and his sister, a 31-year-old woman were investigated. Their respective heights were 114 and 97 cm with proportional statures. Their bone ages were that found in the adult subject. Thyroid functions and metyrapone test were normal and the total urinary gonadotrophin was determined in both cases. HGH secretion was not stimulated by insulin-induced hypoglycaemia, arginine infusion or exercise. Their parents and six other siblings were normal in height. The two patients were therefore assumed to be suffering from an isolated growth hormone deficiency with autosomal recessive inheritance.

scholarly journals Isolated Growth Hormone Deficiency (GHD) in Childhood and Adolescence: Recent Advances

2014 ◽  
Vol 35 (3) ◽  
pp. 376-432 ◽  
Author(s):  
Kyriaki S. Alatzoglou ◽  
Emma Alice Webb ◽  
Paul Le Tissier ◽  
Mehul T Dattani
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Childhood And Adolescence ◽  
Isolated Growth Hormone Deficiency ◽  
Recent Advances

Body composition and quality of life in adults with growth hormone deficiency; effects of low-dose growth hormone replacement

2001 ◽  
Vol 54 (6) ◽  
pp. 709-717 ◽  
Author(s):  
Aftab M. Ahmad ◽  
Marion T. Hopkins ◽  
Joegi Thomas ◽  
Hisham Ibrahim ◽  
William D. Fraser ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Growth Hormone ◽  
Body Composition ◽  
Growth Hormone Deficiency ◽  
Low Dose ◽  
Hormone Replacement ◽  
Hormone Deficiency ◽  
Growth Hormone Replacement

scholarly journals Insulin Sensitivity and β-Cell Function in Adults with Lifetime, Untreated Isolated Growth Hormone Deficiency

2012 ◽  
Vol 97 (3) ◽  
pp. 1013-1019 ◽  
Author(s):  
Carla R. P. Oliveira ◽  
Roberto Salvatori ◽  
Jose A. S. Barreto-Filho ◽  
Ivina E. S. Rocha ◽  
Andrea Mari ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Insulin Sensitivity ◽  
Growth Hormone Deficiency ◽  
Cell Function ◽  
Hormone Deficiency ◽  
Β Cell ◽  
Isolated Growth Hormone Deficiency ◽  
Β Cell Function

Antibody deficiency and isolated growth hormone deficiency in a girl with Mulibrey nanism

1993 ◽  
Vol 152 (6) ◽  
pp. 509-512 ◽  
Author(s):  
Á. Haraldsson ◽  
C. J. A. M. van der Burgt ◽  
C. M. R. Weemaes ◽  
B. Otten ◽  
J. A. J. M. Bakkeren ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Antibody Deficiency ◽  
Hormone Deficiency ◽  
Isolated Growth Hormone Deficiency ◽  
Mulibrey Nanism

scholarly journals Molecular basis for familial isolated growth hormone deficiency.

1981 ◽  
Vol 78 (10) ◽  
pp. 6372-6375 ◽  
Author(s):  
J. A. Phillips ◽  
B. L. Hjelle ◽  
P. H. Seeburg ◽  
M. Zachmann
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Molecular Basis ◽  
Hormone Deficiency ◽  
Isolated Growth Hormone Deficiency
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