Interleukin-1α Enhances Integrin α6β1 Expression and Metastatic Capability of Human Pancreatic Cancer

Oncology ◽  
2003 ◽  
Vol 65 (2) ◽  
pp. 167-173 ◽  
Author(s):  
Hirozumi Sawai ◽  
Hitoshi Funahashi ◽  
Minoru Yamamoto ◽  
Yuji Okada ◽  
Tetsushi Hayakawa ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Human Pancreatic Cancer ◽  
Interleukin 1Α

scholarly journals Interleukin 1α Sustains the Expression of Inflammatory Factors in Human Pancreatic Cancer Microenvironment by Targeting Cancer-Associated Fibroblasts

Neoplasia ◽  
2011 ◽  
Vol 13 (8) ◽  
pp. 664-IN3 ◽  
Author(s):  
Vegard Tjomsland ◽  
Anna Spångeus ◽  
Johanna Välilä ◽  
Per Sandström ◽  
Kurt Borch ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Human Pancreatic Cancer ◽  
Inflammatory Factors ◽  
Cancer Microenvironment ◽  
Cancer Associated Fibroblasts ◽  
Interleukin 1Α

Alteration of Integrins by Interleukin-1α in Human Pancreatic Cancer Cells

Pancreas ◽  
2001 ◽  
Vol 23 (4) ◽  
pp. 399-405 ◽  
Author(s):  
Hirozumi Sawai ◽  
Minoru Yamamoto ◽  
Yuji Okada ◽  
Mikinori Sato ◽  
Yoshimi Akamo ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Human Pancreatic Cancer ◽  
Pancreatic Cancer Cells ◽  
Interleukin 1Α

In Vitro and In Vivo Antitumor Efficacy of Docetaxel and Sorafenib Combination in Human Pancreatic Cancer Cells

2010 ◽  
Vol 999 (999) ◽  
pp. 1-11
Author(s):  
P. Ulivi ◽  
C. Arienti ◽  
W. Zoli ◽  
M. Scarsella ◽  
S. Carloni ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Antitumor Efficacy ◽  
Human Pancreatic Cancer ◽  
Pancreatic Cancer Cells

scholarly journals Oncogene APOL1 promotes proliferation and inhibits apoptosis via activating NOTCH1 signaling pathway in pancreatic cancer

2021 ◽  
Vol 12 (8) ◽  
Author(s):  
Jiewei Lin ◽  
Zhiwei Xu ◽  
Junjie Xie ◽  
Xiaxing Deng ◽  
Lingxi Jiang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Signaling Pathway ◽  
Density Lipoprotein ◽  
Human Pancreatic Cancer ◽  
Luciferase Reporter ◽  
Notch1 Signaling ◽  
In Vivo Experiments ◽  
Notch1 Signaling Pathway

AbstractAPOL1 encodes a secreted high-density lipoprotein, which has been considered as an aberrantly expressed gene in multiple cancers. Nevertheless, the role of APOL1 in the regulatory mechanisms of pancreatic cancer remains unknown and should be explored. We identified APOL1 was abnormally elevated in human pancreatic cancer tissues compared with that in adjacent tissues and was associated with poor prognosis. The effects of APOL1 in PC cell proliferation, cell cycle, and apoptosis was verified via functional in vitro and in vivo experiments. The results showed that knockdown of APOL1 significantly inhibited the proliferation and promoted apoptosis of pancreatic cancer. In addition, we identified APOL1 could be a regulator of NOTCH1 signaling pathway using bioinformatics tools, qRT-PCR, dual-luciferase reporter assay, and western blotting. In summary, APOL1 could function as an oncogene to promote proliferation and inhibit apoptosis through activating NOTCH1 signaling pathway expression in pancreatic cancer; therefore, it may act as a novel therapeutic target for pancreatic cancer.

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