Cytokine mRNA Expression in Isocyanate-Induced Hypersensitivity Pneumonitis

Respiration ◽  
2003 ◽  
Vol 70 (3) ◽  
pp. 284-291 ◽  
Author(s):  
Yuki Sumi ◽  
Min Kyi ◽  
Yasunari Miyazaki ◽  
Yoshio Ohtani ◽  
Shuji Miyake ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Hypersensitivity Pneumonitis ◽  
Cytokine Mrna ◽  
Cytokine Mrna Expression

CYTOKINE mRNA EXPRESSION IN HUMAN PLATELETS AND A MEGAKARYOCYTIC CELL LINE AND CYTOKINE MODULATION OF PLATELET FUNCTION

Cytokine ◽  
1997 ◽  
Vol 9 (6) ◽  
pp. 405-411 ◽  
Author(s):  
Gerald Soslau ◽  
Doris A. Morgan ◽  
Jonathan S. Jaffe ◽  
Isadore Brodsky ◽  
Yihe Wang
Keyword(s):  
Mrna Expression ◽  
Cell Line ◽  
Platelet Function ◽  
Human Platelets ◽  
Cytokine Mrna ◽  
Cytokine Modulation ◽  
Cytokine Mrna Expression ◽  
Megakaryocytic Cell

Fatty acids and cytokine mRNA expression in human osteoblastic cells: a specific effect of arachidonic acid

2002 ◽  
Vol 102 (4) ◽  
pp. 403-409 ◽  
Author(s):  
G. PRIANTE ◽  
L. BORDIN ◽  
E. MUSACCHIO ◽  
G. CLARI ◽  
B. BAGGIO
Keyword(s):  
Fatty Acids ◽  
Arachidonic Acid ◽  
Mrna Expression ◽  
Specific Effect ◽  
Significant Inhibition ◽  
Cytokine Gene Expression ◽  
Dependent Manner ◽  
Human Osteoblast ◽  
Cytokine Mrna ◽  
Cytokine Mrna Expression

Epidemiological, clinical and experimental evidence suggests that fatty acids have a modulatory effect on bone metabolism in animals and humans. To investigate this hypothesis, we evaluated the effects of three different fatty acids, arachidonic acid (AA), eicosapentaenoic acid (EPA) and oleic acid (OA), on the expression of cytokines involved in bone remodelling. Cytokine mRNAs in the human osteoblast-like cell line MG-63 were quantified by reverse transcription-PCR. AA induced increased expression of interleukin-1α, interleukin-1β, tumour necrosis factor-α and macrophage colony-stimulating factor mRNAs in a time- and dose-dependent manner. EPA and OA had no stimulatory effects, but instead caused a significant inhibition of AA-induced cytokine mRNA expression. Cell treatment with calphostin C, an inhibitor of protein kinase C (PKC), and cellular PKC down-regulation experiments independently resulted in significant inhibition of AA-induced cytokine expression, suggesting that a PKC-dependent mechanism accounts for the effects of AA on cytokine production. In conclusion, our study demonstrates specific effects of fatty acids on cytokine gene expression in human osteoblast-like cells. The clinical relevance of our findings requires further investigation.

Upregulation of transcription factors and cytokine mrna expression in taurocholate-induced pancreatitis

2000 ◽  
Vol 118 (4) ◽  
pp. A653
Author(s):  
E. Vaquero ◽  
I. Gukovsky ◽  
V. Zaninovic ◽  
A.S. Gukovskaya ◽  
S.J Pandol
Keyword(s):  
Transcription Factors ◽  
Mrna Expression ◽  
Cytokine Mrna ◽  
Cytokine Mrna Expression
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