Lectin Binding in the Human Umbilical Cord from Normally Grown Pregnancies and from Pregnancies Complicated by Intra-Uterine Growth Retardation with Absent or Reversed Diastolic Flow

Neonatology ◽  
2003 ◽  
Vol 84 (2) ◽  
pp. 119-134 ◽  
Author(s):  
E. Sgambati ◽  
E. Brizzi ◽  
M. Marini ◽  
S. Gheri Bryk ◽  
G. Gheri
Keyword(s):  
Umbilical Cord ◽  
Growth Retardation ◽  
Lectin Binding ◽  
Human Umbilical Cord ◽  
Diastolic Flow ◽  
Uterine Growth ◽  
Intra Uterine Growth Retardation

scholarly journals Effects of prenatal glucocorticoid exposure on cardiac calreticulin and calsequestrin protein expression during early development and in adulthood

2003 ◽  
Vol 371 (1) ◽  
pp. 61-69 ◽  
Author(s):  
Maria L. LANGDOWN ◽  
Mark J. HOLNESS ◽  
Mary C. SUGDEN
Keyword(s):  
Cardiac Function ◽  
Protein Expression ◽  
Growth Retardation ◽  
Premature Death ◽  
Fetal Life ◽  
Dexamethasone Treatment ◽  
Increased Risk ◽  
Uterine Growth ◽  
Intra Uterine Growth Retardation ◽  
Glucocorticoid Action

Overexpression of the conserved Ca2+-binding proteins calreticulin and calsequestrin impairs cardiac function, leading to premature death. Calreticulin is vital for embryonic development, but also impairs glucocorticoid action. Glucocorticoid overexposure during late fetal life causes intra-uterine growth retardation and programmed hypertension in adulthood. To determine whether intra-uterine growth retardation or programmed hypertension was associated with altered calreticulin or calsequestrin expression, effects of prenatal glucocorticoid overexposure (maternal dexamethasone treatment on days 15—21 of pregnancy) were examined during fetal life and postnatal development until adulthood (24 weeks). Dexamethasone (100 or 200μg/kg of maternal body weight) was administered via osmotic pump. Calreticulin was detected as a 55kDa band and calsequestrin as 55 and 63kDa bands in 21 day fetal hearts. Only the 55kDa calsequestrin band was detected postnatally. Prenatal glucocorticoid overexposure at the higher dose decreased calreticulin protein expression (26%; P<0.05) but increased calsequestrin protein expression, both 55 and 63kDa bands, by 87% (P<0.01) and 78% (P<0.01); only the 55kDa calsequestrin band was increased at the lower dose (66%; P<0.05). Offspring of dams treated at the lower dexamethasone dose were studied further. In control offspring, cardiac calreticulin protein expression declined between 2 and 3 weeks of age, and remained suppressed until adulthood. Cardiac calsequestrin protein expression increased 2-fold between fetal day 21 and postnatal day 1 and continued to increase until adulthood, at which time it was 3.4-fold higher (P<0.001). Prenatal dexamethasone exposure minimally affected postnatal calsequestrin protein expression, but the postnatal decline in calreticulin protein expression was abrogated and calreticulin protein expression in adulthood was 2.2-fold increased (P<0.001) compared with adult controls. In view of the known associations between cardiac calreticulin overexpression and impaired cardiac function, targeted up-regulation of calreticulin may contribute to the increased risk of adult heart disease introduced as a result of prenatal overexposure to glucocorticoids.

Association of increased maternal ferritin levels with gestational diabetes and intra-uterine growth retardation

2010 ◽  
Vol 36 (1) ◽  
pp. 58-63 ◽  
Author(s):  
V. Soubasi ◽  
S. Petridou ◽  
K. Sarafidis ◽  
Ch. Tsantali ◽  
E. Diamanti ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Growth Retardation ◽  
Uterine Growth ◽  
Intra Uterine Growth Retardation

Tyrosine α ketoglutarate transaminase in the liver of rats with intra-uterine growth retardation

Life Sciences ◽  
1971 ◽  
Vol 10 (19) ◽  
pp. 1115-1123
Author(s):  
C. Degremont ◽  
J.M. Roux ◽  
E. Swierczewski ◽  
C. Tordet-Caridroit
Keyword(s):  
Growth Retardation ◽  
Uterine Growth ◽  
Intra Uterine Growth Retardation

Umbilical Artery Doppler Waveform in Pregnancies with Uncomplicated Intra-Uterine Growth Retardation

1988 ◽  
Vol 26 (3) ◽  
pp. 206-210 ◽  
Author(s):  
N.G. Haddad ◽  
F.D. Johnstone ◽  
P.R. Hoskins ◽  
S.E. Chambers ◽  
B.B. Muir ◽  
...  
Keyword(s):  
Growth Retardation ◽  
Umbilical Artery ◽  
Doppler Waveform ◽  
Uterine Growth ◽  
Umbilical Artery Doppler ◽  
Intra Uterine Growth Retardation

Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas

2003 ◽  
Vol 81 (3) ◽  
pp. 257-262 ◽  
Author(s):  
J.B. Sharma ◽  
Ashok Kumar ◽  
A. Kumar ◽  
M. Malhotra ◽  
R. Arora ◽  
...  
Keyword(s):  
Growth Retardation ◽  
Uterine Growth ◽  
Intra Uterine Growth Retardation
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