scholarly journals Direct Contact between Human Peripheral Blood Mononuclear Cells and Renal Fibroblasts Facilitates the Expression of Monocyte Chemoattractant Protein-1

2003 ◽  
Vol 23 (4) ◽  
pp. 208-213 ◽  
Author(s):  
Lirong Hao ◽  
Hirokazu Okada ◽  
Yoshihiko Kanno ◽  
Tsutomu Inoue ◽  
Tatsuya Kobayashi ◽  
...  
Keyword(s):  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Direct Contact ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Peripheral Blood Mononuclear ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Blood Mononuclear Cells

scholarly journals Human β-Defensin 2 Induces a Vigorous Cytokine Response in Peripheral Blood Mononuclear Cells

2006 ◽  
Vol 50 (4) ◽  
pp. 1433-1441 ◽  
Author(s):  
Michele Boniotto ◽  
William J. Jordan ◽  
Joyce Eskdale ◽  
Alessandro Tossi ◽  
Nikolinka Antcheva ◽  
...  
Keyword(s):  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Adaptive Immune Response ◽  
Cytokine Response ◽  
Microbial Infection ◽  
Peripheral Blood Mononuclear ◽  
Monocyte Chemoattractant Protein 1 ◽  
Blood Mononuclear Cells

ABSTRACT β-Defensins are a family of small cationic peptides involved in the innate response to microbial infection. Although their role in microbial killing is well established, the mechanisms through which this occurs remain largely undefined. Here, using protein array technology, we describe a role for human β-defensins in the induction of an inflammatory cytokine response by human peripheral blood mononuclear cells (PBMCs). Human β-defensins 1, 2, and 3 were examined for induction of an array of cytokines and chemokines. Some cytokines, such as interleukin 8 (IL-8) and monocyte chemoattractant protein 1, were up-regulated by all three defensins, while others, such as IL-6 and IL-10, were induced more selectively. It was notable that each defensin induced a unique pattern of cytokines. This report documents, for the first time, an analysis of the composite cytokine response of human PBMCs to β-defensins. The induction or up-regulation of a number of cytokines involved in the adaptive immune response suggests a possible role for these defensins in linking innate and acquired immunity.

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