Effect of High-Dose Intravenous Immunoglobulin Therapy in Stevens-Johnson Syndrome: A Retrospective, Multicenter Study

Dermatology ◽  
2003 ◽  
Vol 207 (1) ◽  
pp. 96-99 ◽  
Author(s):  
Christa Prins ◽  
Carmela Vittorio ◽  
R. Steven Padilla ◽  
Thomas Hunziker ◽  
Peter Itin ◽  
...  
Keyword(s):  
Intravenous Immunoglobulin ◽  
Multicenter Study ◽  
Immunoglobulin Therapy ◽  
Stevens Johnson Syndrome ◽  
High Dose ◽  
Intravenous Immunoglobulin Therapy ◽  
Johnson Syndrome ◽  
Retrospective Multicenter Study

scholarly journals A Case of Guillain-Barré Syndrome and Stevens-Johnson Syndrome/Toxic Epidermal Necrosis Overlap After Pembrolizumab Treatment

2021 ◽  
Vol 9 ◽  
pp. 232470962110374
Author(s):  
Tomoyo Oguri ◽  
Shinji Sasada ◽  
Satoko Shimizu ◽  
Risa Shigematsu ◽  
Yumi Tsuchiya ◽  
...  
Keyword(s):  
Intravenous Immunoglobulin ◽  
Immunoglobulin Therapy ◽  
The Body ◽  
Guillain Barre Syndrome ◽  
Stevens Johnson Syndrome ◽  
Intravenous Immunoglobulin Therapy ◽  
Johnson Syndrome ◽  
Guillain Barré Syndrome ◽  
Guillain Barré ◽  
Epidermal Necrosis

A 76-year-old man was admitted to our hospital with Guillain-Barré syndrome (GBS), presenting with facial palsy, dysarthria, and dysphagia as Grade 3 immune-related adverse events (irAEs) due to pembrolizumab administration for Stage IV lung adenocarcinoma. Although prednisolone (1 mg/kg) was started for GBS due to the irAE, dark erythema and skin eruptions appeared on the patient’s torso. Then erosion was observed on 18% of the body surface area and skin biopsy was performed. Finally, the patient was diagnosed with Stevens-Johnson syndrome/toxic epidermal necrosis overlap. Intravenous immunoglobulin therapy was started, and the skin symptoms improved, with the erosion becoming epithelial. He died of aspiration pneumonia related to GBS, although his neurological symptoms had improved after steroid and intravenous immunoglobulin therapy. This is the first reported case of pembrolizumab-induced GBS and Stevens–Johnson syndrome/toxic epidermal necrosis overlap. It is necessary to be careful that the possibility of other severe irAEs may occur simultaneously.

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