scholarly journals Parkinson’s Disease and Mitochondrial DNA NADH Dehydrogenase Subunit 1 Nucleotides 3337–3340: Study in a Population from the Central Region of Portugal (Coimbra)

2003 ◽  
Vol 50 (1) ◽  
pp. 60-61 ◽  
Author(s):  
Manuela Grazina ◽  
Filipe Silva ◽  
Cristina Januário ◽  
Miguel Oliveira ◽  
Luís Cunha ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mitochondrial Dna ◽  
Central Region ◽  
Nadh Dehydrogenase ◽  
Nadh Dehydrogenase Subunit

Novel mitochondrial DNA mutations in Parkinson's disease

2002 ◽  
Vol 109 (5-6) ◽  
pp. 721-729 ◽  
Author(s):  
G. Richter ◽  
A. Sonnenschein ◽  
T. Grünewald ◽  
H. Reichmann ◽  
B. Janetzky
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mitochondrial Dna ◽  
Mitochondrial Dna Mutations ◽  
Dna Mutations

scholarly journals The universal non-neuronal nature of Parkinson's disease: A theory

2015 ◽  
Author(s):  
André Valente ◽  
Altynay Adilbayeva ◽  
Tursonjan Tokay ◽  
Albert Rizvanov
Keyword(s):  
Gene Expression ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mitochondrial Dna ◽  
Late Onset ◽  
Clinical Signs ◽  
Global Gene Expression ◽  
Neuron Death ◽  
Hematopoietic Stem ◽  
Hematopoietic Stem Cell Niche

Various recent developments of relevance to Parkinson's disease (PD) are discussed and integrated into a comprehensive hypothesis on the nature, origin and inter-cellular mode of propagation of late-onset sporadic PD. We propose to define sporadic PD as a characteristic pathological deviation in the global gene expression program of a cell: the PD expression-state, or PD-state for short. Although a universal cell-generic state, the PD-state deviation would be particularly damaging in a neuronal context, ultimately leading to neuron death and the ensuing observed clinical signs. We review why age accumulated damage caused by oxidative stress in mitochondria could be the trigger for a primordial cell to shift to the PD-state. We put forward hematopoietic cells could be the first to acquire the PD-state, at hematopoiesis, from the disruption in reactive oxygen species (ROS) homeostasis that arises with age in the hematopoietic stem-cell niche. We argue why, nonetheless, such a process is unlikely to explain the shift to the PD-state of all the subsequently affected cells in a patient, thus indicating the existence of a distinct mechanism of propagation of the PD-state. We highlight recent findings on the intercellular exchange of mitochondrial DNA and the ability of mitochondrial DNA to modulate the cellular global gene expression state and propose this could form the basis for the intercellular propagation of the PD-state.

scholarly journals Reduced mitochondrial DNA copy number is a biomarker of Parkinson's disease

2016 ◽  
Vol 38 ◽  
pp. 216.e7-216.e10 ◽  
Author(s):  
Angela Pyle ◽  
Haidyan Anugrha ◽  
Marzena Kurzawa-Akanbi ◽  
Alison Yarnall ◽  
David Burn ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mitochondrial Dna ◽  
Copy Number ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number

Mitochondrial DNA Haplogroups and Three Independent Polymorphisms have no Association with the Risk of Parkinson's Disease in East Indian Population

2021 ◽  
Vol 69 (2) ◽  
pp. 461
Author(s):  
Mainak Sengupta ◽  
Tania Saha ◽  
Somrita Roy ◽  
Rajashree Chakraborty ◽  
Arindam Biswas ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mitochondrial Dna ◽  
Indian Population ◽  
East Indian

scholarly journals Delta deletion 4977 in mitochondrial DNA in patients with idiopathic Parkinson’s disease

2014 ◽  
Vol 115 (01) ◽  
pp. 7-13 ◽  
Author(s):  
A. Taravari ◽  
S. Panov ◽  
I. Petrov ◽  
V. Petrova ◽  
F. Medziti ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mitochondrial Dna ◽  
Idiopathic Parkinson’S Disease ◽  
Idiopathic Parkinson's Disease

scholarly journals Relationship between mitochondrial DNA A10398G polymorphism and Parkinson's disease: a meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (44) ◽  
pp. 78023-78030 ◽  
Author(s):  
Feifei Hua ◽  
Xiaona Zhang ◽  
Binghui Hou ◽  
Li Xue ◽  
Anmu Xie
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mitochondrial Dna ◽  
Meta Analysis
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