Induction of Early Growth Response Gene Egr2 by Basic Calcium Phosphate Crystals through a Calcium-Dependent Protein Kinase C-Independent p44/42 Mitogen-Activated Protein Kinase Pathway

2003 ◽  
Vol 174 (1-2) ◽  
pp. 63-72 ◽  
Author(s):  
Xiao R. Zeng ◽  
Yubo Sun ◽  
Leonor Wenger ◽  
Herman S. Cheung
Keyword(s):  
Protein Kinase ◽  
Mitogen Activated Protein Kinase ◽  
Early Growth Response ◽  
Calcium Dependent ◽  
Kinase C ◽  
Early Growth Response Gene ◽  
Mitogen Activated Protein ◽  
Dependent Protein ◽  
Basic Calcium Phosphate Crystals ◽  
Kinase Pathway

scholarly journals High glucose activates rat pancreatic stellate cells through protein kinase C and p38 mitogen-activated protein kinase pathway

Suizo ◽  
2007 ◽  
Vol 22 (5) ◽  
pp. 595-597
Author(s):  
Yoko Nomiyama ◽  
Mitsuo Tashiro ◽  
Taizo Yamaguchi ◽  
Shiro Watanabe ◽  
Masashi Taguchi ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
High Glucose ◽  
Stellate Cells ◽  
Mitogen Activated Protein Kinase ◽  
Pancreatic Stellate Cells ◽  
Kinase C ◽  
Mitogen Activated Protein ◽  
Kinase Pathway

scholarly journals Identification of Msp1-Induced Signaling Components in Rice Leaves by Integrated Proteomic and Phosphoproteomic Analysis

2019 ◽  
Vol 20 (17) ◽  
pp. 4135 ◽  
Author(s):  
Ravi Gupta ◽  
Cheol Woo Min ◽  
Yu-Jin Kim ◽  
Sun Tae Kim
Keyword(s):  
Plasma Membrane ◽  
Protein Kinase ◽  
Defense Responses ◽  
Mitogen Activated Protein Kinase ◽  
Calcium Dependent ◽  
Molecular Pattern ◽  
Mitogen Activated Protein ◽  
Dependent Protein ◽  
Rice Leaves ◽  
Respiratory Burst Oxidase

MSP1 is a Magnaporthe oryzae secreted protein that elicits defense responses in rice. However, the molecular mechanism of MSP1 action is largely elusive. Moreover, it is yet to be established whether MSP1 functions as a pathogen-associated molecular pattern (PAMP) or an effector. Here, we employed a TMT-based quantitative proteomic analysis of cytosolic as well as plasma membrane proteins to decipher the MSP1 induced signaling in rice. This approach led to the identification of 6691 proteins, of which 3049 were identified in the plasma membrane (PM), while 3642 were identified in the cytosolic fraction. A parallel phosphoproteome analysis led to the identification of 1906 phosphopeptides, while the integration of proteome and phosphoproteome data showed activation of proteins related to the proteolysis, jasmonic acid biosynthesis, redox metabolism, and MAP kinase signaling pathways in response to MSP1 treatment. Further, MSP1 induced phosphorylation of some of the key proteins including respiratory burst oxidase homologue-D (RBOHD), mitogen-activated protein kinase kinase kinase-1 (MEKK1), mitogen-activated protein kinase-3/6 (MPK3/6), calcium-dependent protein kinase (CDPK) and calmodulin (CaM) suggest activation of PAMP-triggered immunity (PTI) in response to MSP1 treatment. In essence, our results further support the functioning of MSP1 as a PAMP and provide an overview of the MSP1 induced signaling in rice leaves.

Calcium-dependent stimulation of the p44/42 mitogen-activated protein kinase pathway by acetylcholine in isolated human colonic crypts

2001 ◽  
Vol 120 (5) ◽  
pp. A700
Author(s):  
Susanne M. Lindqvist ◽  
James M. Hernon ◽  
Paul A. Sharp ◽  
Ian T. Johnson ◽  
Jean Mackay ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Mitogen Activated Protein Kinase ◽  
Calcium Dependent ◽  
Colonic Crypts ◽  
Mitogen Activated Protein ◽  
Kinase Pathway ◽  
Stimulation Of
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