Serum Concentration of Type IV Collagen 7S Domain as a Marker for Increased Risk of Recurrence after Liver Resection for Hepatocellular Carcinoma

2003 ◽  
Vol 20 (3) ◽  
pp. 201-208 ◽  
Author(s):  
Shuichi Kawai ◽  
Shoji Kubo ◽  
Tadashi Tsukamoto ◽  
Hiromu Tanaka ◽  
Taichi Shuto ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Serum Concentration ◽  
Type Iv Collagen ◽  
Risk Of Recurrence ◽  
Type Iv ◽  
Increased Risk ◽  
Type Iv Collagen 7S

scholarly journals Advancement of hepatic fibrosis among general women with/without NAFLD

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
R Ibusuki ◽  
I Shimoshikiryo ◽  
K Shimatani ◽  
D Nishimoto ◽  
S Maenohara ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
General Population ◽  
Fatty Liver ◽  
Hepatic Fibrosis ◽  
Type Iv Collagen ◽  
Related Factors ◽  
Abdominal Ultrasonography ◽  
Type Iv ◽  
Type Iv Collagen 7S

Abstract Background Nonalcoholic fatty liver disease (NAFLD) is increasing, being prevalent at 30% of the general population worldwide. A part of NAFLD develops nonalcoholic steatohepatitis (NASH), liver cirrhosis and hepatocellular carcinoma. Hepatic fibrosis plays an important role in their pathogenesis. However, it is unclear how hepatic fibrosis is observed and advanced in NAFLD among general population. To investigate the hepatic fibrosis among general population, we prospectively observed hepatic fibrosis using serum markers. Methods The subjects were 228 women who participated as a part of the Japan Multi-Institutional Collaborative Cohort (J-MICC) study in Kagoshima, Japan, and were followed from 2005 to 2014. NAFLD was defined as fatty liver by abdominal ultrasonography; consuming ethanol < 20 g/day; and being none hepatitis B and C carriers. NAFLD were confirmed after two-time consecutive examination, because its disappearance is ambiguous in some cases. Hepatic fibrosis was evaluated using serum M2BPGi and Type IV collagen 7s. The comparison of their changed values between groups was done using the ANOVA adjusted for age. The association between their change and related factors was done using general linear regression model. Results The prevalence of NAFLD was 31.6% at baseline. In the 5-year observation, the NAFLD + => NAFLD + ( ++) group was 23.7%; − +, 2.6%; + −, 7.9%; and - - (control), 65.8%. The values of M2BPGi and Type IV collagen 7s were higher in ++, -+, +- groups than controls at baseline. The change of M2BPGi values was observed in all groups, including controls, and the changed values were higher in ++ and -+ groups. Higher creatinine levels were positively associated with change of M2BPGi values. In contrast, the change of Type IV collagen 7s was not apparent. Conclusions This study suggested hepatic fibrosis was advanced with age among general women without NAFLD, and the presence of NAFLD enhanced hepatic fibrosis more. Key messages Hepatic fibrosis may be slightly developing with age among general population, and will be enhanced with fatty liver. It is important to prevent fatty liver development to control risk factors, such as obesity and metabolic syndrome, to reduce the risk of NASH, liver cirrhosis and hepatocellular carcinoma.

Type IV Collagen 7s Domain as a Predictor of Poor Efficacy of Portal Vein Embolization Before Major Hepatectomy

Surgery Today ◽  
2005 ◽  
Vol 35 (1) ◽  
pp. 41-46 ◽  
Author(s):  
Jin Shang Wu ◽  
Shoji Kubo ◽  
Hiromu Tanaka ◽  
Taichi Shuto ◽  
Shigekazu Takemura ◽  
...  
Keyword(s):  
Portal Vein ◽  
Portal Vein Embolization ◽  
Type Iv Collagen ◽  
Major Hepatectomy ◽  
Type Iv ◽  
Type Iv Collagen 7S ◽  
Poor Efficacy

scholarly journals Type IV Collagen 7S Is the Most Accurate Test For Identifying Advanced Fibrosis in NAFLD With Type 2 Diabetes

2020 ◽  
Author(s):  
Hiroshi Ishiba ◽  
Yoshio Sumida ◽  
Yuya Seko ◽  
Saiyu Tanaka ◽  
Masato Yoneda ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Type Iv Collagen ◽  
Advanced Fibrosis ◽  
Type Iv ◽  
Type Iv Collagen 7S

P2623Measurement of liver fibrosis marker: type IV collagen 7S among patients with acute heart failure and its relationship with the Enhanced Liver Fibrosis (ELF) score

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
K Aida ◽  
K Nagao ◽  
K Kajitani ◽  
A Tamura ◽  
T Kobayashi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Liver Fibrosis ◽  
Acute Heart Failure ◽  
Type Iv Collagen ◽  
Hazard Ratio ◽  
Adjusted Hazard Ratio ◽  
High Group ◽  
Type Iv ◽  
Fibrosis Marker ◽  
Type Iv Collagen 7S

Abstract Background Hemodynamic disturbance in acute heart failure (HF) can cause injury to extra-cardiac organs such as the liver. Organ injury in HF might evoke a profibrotic response, which could adversely affect the prognosis. Methods Among 189 patients with acute HF, we simultaneously determined the liver fibrosis marker, type IV collagen 7S (P4NP 7S) and the Enhanced Liver Fibrosis (ELF) Score consisting of tissue inhibitor of metalloproteinases 1 (TIMP-1), amino-terminal propeptide of type III procollagen (PIIINP) and hyaluronic acid (HA) on admission and at discharge. Results During hospitalization, P4NP 7S and ELF score significantly decreased from 7.1 ng/mL to 6.1 ng/mL (P<0.001) and 10.39 to 10.13 (P<0.001), respectively. P4NP 7S and ELF score were correlated with each other on admission (r=0.4, P<0.001) and at discharge (r=0.4, P<0.001). %Change of (Δ) P4NP 7S during hospitalization was correlated with ΔBNP and ΔELF score (r=0.3, P<0.001 and r=0.4, P<0.001, respectively). Among the components of ELF score, PIIINP and HA were correlated with P4NP 7S on admission (r=0.5, P<0.001 and r=0.3, P<0.001, respectively) and at discharge (r=0.4, P<0.001 and r=0.3, P<0.001, respectively). ΔP4NP 7S was also correlated with ΔTIMP-1, ΔPIIINP and ΔHA (r=0.3, P<0.001, r=0.4, P<0.001 and r=0.3, P<0.001, respectively). Each patient was followed up up to 365 days after discharge. 69 patients died or were hospitalized for HF. When the patients were divided into two groups according to the median value of each marker at discharge, the cumulative 1-year incidences of all cause death or HF hospitalization were 32.0% and 45.5% in P4NP 7S-low and P4NP 7S-high group, respectively (log-rank P=0.051) and 43.2% and 34.9% in ELF score-low and ELF score-high group, respectively (log-rank P=0.44). After adjustment by the clinically relevant factors including age, sex, hemoglobin, sodium and left ventricular ejection fraction, P4NP 7S showed independent prognostic value (adjusted hazard ratio: 1.12, P=0.02), while ELF score did not (adjusted hazard ratio: 1.04, P=0.79). Conclusion Parallel elevation of P4NP 7S and ELF score were documented during acute phase of HF. P4NP 7S at discharge may identify patients at high risk for subsequent HF related events.

Peritoneal Injury by Methylglyoxal in Peritoneal Dialysis

2006 ◽  
Vol 26 (3) ◽  
pp. 380-392 ◽  
Author(s):  
Ichiro Hirahara ◽  
Eiji Kusano ◽  
Satoru Yanagiba ◽  
Yukio Miyata ◽  
Yasuhiro Ando ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Basement Membrane ◽  
Structural Changes ◽  
Type Iv Collagen ◽  
Degradation Products ◽  
Abdominal Cocoon ◽  
Type Iv ◽  
Type Iv Collagen 7S ◽  
Peritoneal Function

Background Peritoneal dialysis (PD) is a common treatment for patients with reduced or absent renal function. Long-term PD leads to peritoneal injury with structural changes and functional decline, such as ultrafiltration loss. At worst, peritoneal injury leads to encapsulating peritoneal sclerosis, a serious complication of PD. Glucose degradation products contained in PD fluids contribute to the bioincompatibility of conventional PD fluids. Methylglyoxal (MGO) is an extremely toxic glucose degradation product. The present study examined the injurious effect of MGO on peritoneum in vivo. Methods Male Sprague–Dawley rats ( n = 6) were administered PD fluids (pH 5.0) containing 0, 0.66, 2, 6.6, or 20 mmol/L MGO every day for 21 days. On day 22, peritoneal function was estimated by the peritoneal equilibration test. Drained dialysate was analyzed for type IV collagen-7S, matrix metalloproteinase (MMP), and vascular endothelial growth factor (VEGF). Histological analysis was also performed. Results In rats receiving PD fluids containing more than 0.66 mmol/L MGO, peritoneal function decreased significantly and levels of type IV collagen-7S and MMP-2 in drained dialysate increased significantly. In the 20-mmol/L MGO-treated rats, loss of body weight, expression of VEGF, thickening of the peritoneum, and formation of abdominal cocoon were induced. MMP-2 and VEGF were produced by infiltrating cells in the peritoneum. Type IV collagen was detected in basement membrane of microvessels. Conclusion MGO induced not only peritoneal injury but also abdominal cocoon formation in vivo. The decline of peritoneal function may result from reconstitution of microvessel basement membrane or neovascularization.

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