Incidence, Risk Factors and Prognosis of Stroke and TIA: The Need for High-Quality, Large-Scale Epidemiological Studies and Meta-Analyses

2003 ◽  
Vol 16 (3) ◽  
pp. 2-10 ◽  
Author(s):  
Peter M. Rothwell
Keyword(s):  
Risk Factors ◽  
Large Scale ◽  
Epidemiological Studies ◽  
High Quality ◽  
Incidence Risk ◽  
Meta Analyses

scholarly journals A Molecular Survey on Neglected Gurltia paralysans and Aelurostrongylus abstrusus Infections in Domestic Cats (Felis catus) from Southern Chile

Pathogens ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1195
Author(s):  
Natasha Barrios ◽  
Marcelo Gómez ◽  
Macarena Zanelli ◽  
Lisbeth Rojas-Barón ◽  
Paulina Sepúlveda-García ◽  
...  
Keyword(s):  
Risk Factors ◽  
Large Scale ◽  
Nematode Species ◽  
Epidemiological Studies ◽  
Felis Catus ◽  
Domestic Cat ◽  
Southern Chile ◽  
Domestic Cats ◽  
Aelurostrongylus Abstrusus ◽  
Factors Associated

Gurltia paralysans and Aelurostrongylus abstrusus are neglected metastrongyloid nematode species which infect domestic and wild cats in South American countries and in Chile, but no epidemiological studies on concomitant infections have been conducted in Chile so far. The aim of this study was not only to evaluate the occurrence of concomitant infections, but also to identify epidemiological risk factors associated with of G. paralysans and A. abstrusus infections in urban domestic cats (Felis catus) from Southern Chile. Blood samples from clinically healthy domestic cats from three cities of Southern Chile—Temuco, Valdivia, and Puerto Montt—were analyzed by an experimental semi-nested PCR protocol. A total of 171 apparently healthy domestic cats in Temuco (n = 68), Valdivia (n = 50), and Puerto Montt (n = 53) were sampled and analyzed. A total of 93 domestic cats (54.4%) were positive for G. paralysans, and 34 (19.9%) were positive for A. abstrusus infections. From those animals, 34 (19.9%) were co-infected. Cats positive with G. paralysans were found in all three cities; 47.2% in Puerto Montt, 48% in Valdivia, and 64.7% in Temuco. Levels of infection for A. abstrusus in the population under study were 4% (Valdivia), 10% (Puerto Montt), and 32.4% (Temuco). The present large-scale epidemiological study confirmed the presence of these neglected nematodes in domestic cat populations in Southern Chile, and described the possible risk factors associated with feline gurltiosis and aelurostrongylosis.

Introduction: A ‘fourth age’ of psychiatric epidemiology?

2020 ◽  
pp. 1-4
Author(s):  
Jayati Das-Munshi ◽  
Tamsin Ford ◽  
Matthew Hotopf ◽  
Martin Prince ◽  
Robert Stewart
Keyword(s):  
Healthcare Service ◽  
Large Scale ◽  
Complex Interventions ◽  
Epidemiological Studies ◽  
Wearable Devices ◽  
Psychiatric Epidemiology ◽  
High Quality ◽  
Oxford University ◽  
Large Scale Data ◽  
Scale Data

This is the introduction to the second edition of ‘Practical Psychiatric Epidemiology’ published by Oxford University Press. In this introduction the Editors reflect on developments since the first edition. Themes touched upon include the ongoing need for high quality descriptive data, the contribution of wearable devices and technologies to generating data for psychiatric epidemiological studies, developments relating to the availability of large-scale data resources or so-called ‘big data’ in psychiatric epidemiology, ongoing issues relating to accurate measurement in psychiatric epidemiology and the contribution of complex interventions to effective healthcare service delivery, and in particular, the way in which these are effectively implemented. The chapter concludes with a reflection on the continued importance of psychiatric epidemiology to the field of mental health.

Lifestyle and sociodemographic risk factors for gastroschisis: a systematic review and meta-analysis

2020 ◽  
Vol 105 (8) ◽  
pp. 756-764 ◽  
Author(s):  
Silvia Baldacci ◽  
Michele Santoro ◽  
Alessio Coi ◽  
Lorena Mezzasalma ◽  
Fabrizio Bianchi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Genetic Risk ◽  
Illicit Drugs ◽  
Meta Analysis ◽  
Genetic Risk Factors ◽  
Epidemiological Studies ◽  
Black Mothers ◽  
Increased Risk ◽  
Sociodemographic Risk ◽  
Meta Analyses

BackgroundGastroschisis is strongly associated with young maternal age. This association suggests the need for further investigations on non-genetic risk factors. Identifying these risk factors is a public health priority in order to develop prevention strategies aimed at reducing the prevalence and health consequences in offspring.ObjectiveTo systematically assess and quantitatively synthesise the available epidemiological studies to evaluate the association between non-genetic risk factors and gastroschisis.MethodsLiterature from PubMed, EMBASE and Scopus was searched for the period 1990–2018. Epidemiological studies reporting risk estimates between lifestyle and sociodemographic risk factors and gastroschisis were included. Two pairs of reviewers independently extracted information on study characteristics following Preferred Reporting Items for Systematic Reviews and Meta-Analyses and MOOSE (Meta-analysis Of Oservational Studies in Epidemiology) guidelines. Relative risk (RR) estimates were calculated across the studies and meta-analysis was performed using random-effects model.ResultsWe identified 58 studies. Meta-analyses were conducted on 29 studies. Maternal smoking (RR 1.56, 95% CI 1.40 to 1.74), illicit drug use (RR 2.14, 95% CI 1.48 to 3.07) and alcohol consumption (RR 1.40, 95% CI 1.13 to 1.70) were associated with an increased risk of gastroschisis. A decreased risk among black mothers compared with non-Hispanic white mothers (RR 0.49, 95% CI 0.38 to 0.63) was found. For Hispanic mothers no association was observed.ConclusionsExposure to smoking, illicit drugs and alcohol during pregnancy is associated with an increased risk of gastroschisis. A significantly decreased risk for black mothers was observed. Further epidemiological studies to assess the potential role of other environmental factors are strongly recommended.PROSPERO registration numberCRD42018104284.

Venous thromboembolism in patients with renal cell carcinoma: Incidence, risk factors, and prognostic implication.

2012 ◽  
Vol 30 (5_suppl) ◽  
pp. 446-446 ◽  
Author(s):  
Ha-young Lee ◽  
Eunhee Park ◽  
Soohyeon Lee ◽  
Soojung Hong ◽  
Hyun Jung Park ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thromboembolism ◽  
Cumulative Incidence ◽  
Renal Cell ◽  
Large Scale ◽  
Time Course ◽  
Stage Iv ◽  
Severance Hospital ◽  
Incidence Risk ◽  
Ecog Ps

446 Background: Renal cell ca (RCC) is one of solid tumor with relatively highest incidence of venous thromboembolism (VTE). But, there have been to no large-scale studies that focused on VTE in RCC. The aim of this study was to investigate the incidence, time course of VTE, risk factors, and prognosis associated with VTE in RCC patients in Korea. Methods: The medical records of RCC patients (n=1248) histologically diagnosed at Severance Hospital, Yonsei University College of Medicine, Seoul, Korea from Jan 2005 to Mar 2011 were retrospectively reviewed. Results: Among 1248 RCC patients, 69.6% were men, median age was 56years (range: 4∼89), and stage distribution was stage I 65.1%, stage II 9.2%, stage III 10.4%, stage IV 12.5%. The 2-year cumulative incidences of tumor induced VTE (tVTE) was detected in 78 patients (6.3%), while 1-month, 6-months and 1-year cumulative incidence of tVTE were 5.3%, 5.7% and 6.0%, retrospectively. Two-year cumulative incidence of tVTE seemed to increase with stage (0.6%, 3.5%, 22.3% and 24.3% in stages I, II, III and IV, retrospectively). Almost tVTE events developed in the first few months after diagnosis. Stage and metastatic disease were independent risk factors for developing tVTE. In multivariate analysis, the development of tVTE was a significant predictor of survival (P=0.004) and stage, age, ECOG PS was also independent predictor of survival. Conclusions: This is the first study that specially focused on tVTE in RCC. The 2-year cumulative incidence of tVTE in Korean patients with RCC was 6.3%, which is similar to other ethnic group. As tVTE related to poorer survival, RCC patients with advanced stage and metastasis with higher risk of tVTE, close follow-up is recommended and proactive prophylaxis of VTE might be needed.

scholarly journals METHODOLOGICAL APPROACHES TO EVALUATION AND PREDICTION OF INDIVIDUAL RISK TO HEALTH UNDER THE EXPOSURE TO A COMPLEX OF DIFFERENT FACTORS FOR TASKS OF PERSONALIZED PROPHYLAXIS

2018 ◽  
Vol 97 (1) ◽  
pp. 34-43
Author(s):  
Marina A. Zemlyanova ◽  
N. V. Zaytseva ◽  
D. A. Kiryanov ◽  
O. Yu. Ustinova
Keyword(s):  
Risk Factors ◽  
Large Scale ◽  
Epidemiological Studies ◽  
Individual Risk ◽  
Scientific Publications ◽  
Managerial Decisions ◽  
Model Library ◽  
Genetic Status ◽  
Somatic Status ◽  
The Individual

Methodical approaches to the assessment and prediction of the individual risk for the development of diseases associated with the effect of a complex of heterogeneous factors, taking into account the features of the genetic and somatic status of the individual for the tasks of personalized prevention, are suggested. The conceptual basis of the methodology is the presentation of the individual risk for diseases as a quantity that varies with time depending on the level and duration of the exposure of the acting factors (evolution), with respect to the contribution of natural causes. There is presented a model describing the evolution of individual risk, which takes into account a complex system of dependencies of the indices of the body’s somatic state and genetic status on the variable exposure of factors. To assess the value of the individual risk, there are proposed a scale and a system of criteria for the assessment of the likelihood of the development of the disease with taking account of its severity. The established value of the individual risk in relation to a specific disease determines the list, scope and sequence of measures for the personalized prevention, and is also a measure of their effectiveness. A large-scale epidemiological study of the population (about 10 thousand people) from 12 regions of the Russian Federation was executed. There was obtained a system of dependencies which reflects the cause-effect relationships between indices characterizing the factors of habitat and lifestyle, the body’s somatic and genetic status (more than 500 indices), the probability of diseases associated with risk factors (about 20 nosological forms). There was created a special replenished information resource «Model Library» has been created, including parameters of more than 4 thousand adequate and reliable dependencies of cause-effect relationships, revealed by relying upon the results of own epidemiological studies and analysis of domestic and foreign scientific publications. An algorithm for the estimation and prediction the individual risk has been developed for the formation of personalized prevention programs aimed at its reducing. The algorithm is implemented in the form of an information and analytical system that can be used as a tool for making managerial decisions in the field of personalized prevention of diseases associated with risk factors at the group and population levels.

scholarly journals Environmental risk factors of pregnancy outcomes: a summary of recent meta-analyses of epidemiological studies

2013 ◽  
Vol 12 (1) ◽  
Author(s):  
Mark J Nieuwenhuijsen ◽  
Payam Dadvand ◽  
James Grellier ◽  
David Martinez ◽  
Martine Vrijheid
Keyword(s):  
Risk Factors ◽  
Environmental Risk ◽  
Pregnancy Outcomes ◽  
Epidemiological Studies ◽  
Environmental Risk Factors ◽  
Meta Analyses

scholarly journals Factors affecting male fertility: a review

2021 ◽  
Vol 6 (2) ◽  
pp. 124-135
Author(s):  
N. A. Litvinova ◽  
A. I. Lesnikov ◽  
T. A. Tolochko ◽  
A. A. Shmelev
Keyword(s):  
Risk Factors ◽  
Male Infertility ◽  
Climatic Factors ◽  
Inflammatory Diseases ◽  
Epidemiological Studies ◽  
Working Environment ◽  
Factors Affecting ◽  
Sexually Transmitted ◽  
Hormonal Imbalance ◽  
Meta Analyses

Male infertility is an urgent medical and demographic threat worldwide, in particular in industrial regions suffering from environmental pollution. Here we performed an analysis of epidemiological studies and meta-analyses of prevalence, causes, and risk factors of male reproductive disorders. Among the well-defined risk factors determining male infertility are hormonal imbalance, sexually transmitted infections, other inflammatory diseases, hereditary mutations, and congenital malformations. Less studied causes of male infertility are acquired mutations and gene polymorphisms, immune disorders, oxidative stress, and chronic conditions. To date, there is no consensus on the contribution of lifestyle, bad habits, working environment, and climatic factors to male infertility. As such, 40-50% male infertility cases are characterized as idiopathic. 

scholarly journals Incidence, risk factors and outcomes of early postoperative hyperglycemia in surgical patients: a protocol for a systematic review and meta-analysis

2020 ◽  
Author(s):  
Paddy Ssentongo ◽  
Joseph A. Lewcun ◽  
Anna E. Ssentongo ◽  
David I. Soybel
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Clinical Outcomes ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Postoperative Outcomes ◽  
Cochrane Library ◽  
Logit Transformation ◽  
Incidence Risk ◽  
Meta Analyses

Abstract Background Early postoperative hyperglycemia is common and associated with poor postoperative outcomes. We aimed to estimate the pooled incidence, risk factors and clinical outcomes of early postoperative hyperglycemia in men and women globally. Method and analysis We will conduct a systematic review and meta-analysis of cohort studies published before January 1, 2020, reporting the incidence of postoperative hyperglycemia. We will search the following databases: PubMed (MEDLINE), Scopus, EMBASE, Cochrane Library, OVID (HEALTH STAR), OVID (MEDLINE), Joana Briggs Institute EBF Database and Web of Science. No age, geographical location, study-design or language limits will be applied. This protocol was developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guidelines. Two reviewers (JAL, AES) will independently screen citations, abstracts and will identify full-text articles for inclusion, extract data and evaluate the quality and bias of included studies. Discrepancies will be resolved by consensus or consultation with a third researcher (PS). The risk of bias of included studies will be evaluated by the appropriate Cochrane risk of bias tool. The primary outcome will be the overall incident rate of postoperative hyperglycemia. Secondary outcomes are the risk factors and clinical outcomes of postoperative hyperglycemia. We will use the random-effects model with a logit transformation of proportions for the pooling of studies. We will assess the between-study heterogeneity using the I 2 statistic, and Cochrane’s Q statistic (significance level < 0.05). We will perform subgroup meta-analyses to look at geographical differences in the incidence of postoperative hyperglycemia and conduct a meta-regression analysis, using study level median age, year of publication, study level gender proportions, the proportion of type 2 diabetes, mean body mass index, American Society of Anesthesiologists and type of surgical procedure. We will report the probability of postoperative hyperglycemia as a measure of incidence rate, relative risk ratios (RR) and 95% confidence intervals to report the effects of the risk factors and postoperative outcomes. The Egger’s test and funnel plots will be used to assess publication bias.

scholarly journals Selected socio-economic aspects of the risk of hypertension

2020 ◽  
Vol 26 (2) ◽  
pp. 155-162
Author(s):  
D. P. Tsygankova ◽  
N. V. Fedorova
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Large Scale ◽  
Pathological Condition ◽  
Economic Status ◽  
Epidemiological Studies ◽  
Convincing Evidence ◽  
The Body ◽  
Rapid Urbanization ◽  
Prevention And Treatment

Hypertension (HTN) is one of the most common diseases and a risk factor leading to disabling and fatal complications. Large-scale epidemiological studies in all countries convincingly prove the need for early prevention and treatment of this pathological condition. In conditions of rapid urbanization, it is necessary to look for individual measures for the prevention and treatment. In addition to the main risk factors for HTN, such as low physical activity and increased body weight, smoking, alcohol abuse, as well as sex and age, there is convincing evidence that the level of education, economic status, professional affiliation, living conditions are also potential predictors of HTN. The review presents an analysis of the main socio-economic risk factors for HTN and the mechanisms of their influence on blood pressure. The article discusses each factor, its impact on blood pressure and the body as a whole, as well as approaches for the identification of these factors.

scholarly journals Large-scale evidence generation and evaluation across a network of databases (LEGEND): assessing validity using hypertension as a case study

2020 ◽  
Vol 27 (8) ◽  
pp. 1268-1277 ◽  
Author(s):  
Martijn J Schuemie ◽  
Patrick B Ryan ◽  
Nicole Pratt ◽  
RuiJun Chen ◽  
Seng Chan You ◽  
...  
Keyword(s):  
Propensity Score ◽  
Confidence Intervals ◽  
External Validity ◽  
Large Scale ◽  
Internal Validity ◽  
Medical Decision ◽  
Observational Research ◽  
High Quality ◽  
Meta Analyses ◽  
Evidence Generation

Abstract Objectives To demonstrate the application of the Large-scale Evidence Generation and Evaluation across a Network of Databases (LEGEND) principles described in our companion article to hypertension treatments and assess internal and external validity of the generated evidence. Materials and Methods LEGEND defines a process for high-quality observational research based on 10 guiding principles. We demonstrate how this process, here implemented through large-scale propensity score modeling, negative and positive control questions, empirical calibration, and full transparency, can be applied to compare antihypertensive drug therapies. We assess internal validity through covariate balance, confidence-interval coverage, between-database heterogeneity, and transitivity of results. We assess external validity through comparison to direct meta-analyses of randomized controlled trials (RCTs). Results From 21.6 million unique antihypertensive new users, we generate 6 076 775 effect size estimates for 699 872 research questions on 12 946 treatment comparisons. Through propensity score matching, we achieve balance on all baseline patient characteristics for 75% of estimates, observe 95.7% coverage in our effect-estimate 95% confidence intervals, find high between-database consistency, and achieve transitivity in 84.8% of triplet hypotheses. Compared with meta-analyses of RCTs, our results are consistent with 28 of 30 comparisons while providing narrower confidence intervals. Conclusion We find that these LEGEND results show high internal validity and are congruent with meta-analyses of RCTs. For these reasons we believe that evidence generated by LEGEND is of high quality and can inform medical decision-making where evidence is currently lacking. Subsequent publications will explore the clinical interpretations of this evidence.

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