‘In vitro’ Cytokine Secretion by Peripheral Blood and Decidual Lymphocytes during the Third Trimester of Normal Pregnancy

2003 ◽  
Vol 55 (2) ◽  
pp. 68-72 ◽  
Author(s):  
J.R. Wilczynski ◽  
H. Tchórzewski ◽  
E. Głowacka ◽  
M. Banasik ◽  
M. Szpakowski ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Normal Pregnancy ◽  
Cytokine Secretion ◽  
Third Trimester ◽  
The Third

scholarly journals Natural Killer Cells and Their Activation Status in Normal Pregnancy

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Beatrice Mosimann ◽  
Marion Wagner ◽  
Hassan Shehata ◽  
Leona C. Y. Poon ◽  
Brian Ford ◽  
...  
Keyword(s):  
Nk Cells ◽  
Peripheral Blood ◽  
Nk Cell ◽  
Normal Pregnancy ◽  
Third Trimester ◽  
Vitro Fertilization ◽  
Cell Counts ◽  
Increased Risk ◽  
Singleton Pregnancies

Increased peripheral blood-activated NK cell counts are associated with increased risk of miscarriage and failed in vitro fertilization treatment. However, assessment of activated peripheral NK cells in normal and pathological pregnancies beyond implantation and early miscarriage has not been described. Total CD69 expressing NK cells counts were measured by flow cytometry in healthy women with singleton pregnancies, including 45 at 11+6–13+6weeks’ gestation, 46 at 20+0–22+4weeks, and 42 at 31+6–33+5weeks. The number of peripheral blood NK cells decreased, whereas the percentage of activated CD69 expressing NK cells increased from the first to the third trimester of pregnancy. This study shows the course of peripheral blood NK cells and activated CD69 expressing NK cells in uncomplicated nulliparous singleton pregnancies. This is a first step in understanding their implication in pathological pregnancies.

scholarly journals Differentiation of memory cells in the T-helper subset during normal pregnancy andpreeclampsy

2013 ◽  
Vol 62 (2) ◽  
pp. 110-116 ◽  
Author(s):  
Anna Vldimirovna Kudryashova ◽  
Natalya Yuryevna Sotnikova ◽  
Irina Aleksandrovna Panova ◽  
Lyudmila Viktorovna Kadyrova
Keyword(s):  
Peripheral Blood ◽  
First Trimester ◽  
Normal Pregnancy ◽  
Th2 Cells ◽  
Memory Cells ◽  
Second Trimester ◽  
T Helper ◽  
Third Trimester ◽  
The Third ◽  
High Level

The amount of Th1и and Th2 cells in the peripheral blood increased in the first trimester and remained at the high level during all the process of gestation. Changes in the quantity of memory cells were defined: by the enhanced level of Temra in the CD4+ subset and of IFNγ+ cells in the population of CD4+ Temra in the second trimester; by restoring the balance of Tcm, Tem and Temra to the values of nonpregnant donors in the third trimester. In preeclampsy pregnancy the level Th1, Th2 and IFNγ+ cells in CD4+ population of Temra was significantly higher then in normal pregnancy.

Dual In Vitro Perfusion of an Isolated Cotyledon as a Model to Study the Implication of Changes in the Third Trimester Placenta on Preeclampsia

Placenta ◽  
2007 ◽  
Vol 28 ◽  
pp. S23-S32 ◽  
Author(s):  
S. Di Santo ◽  
R. Sager ◽  
A.-C. Andres ◽  
S. Guller ◽  
H. Schneider
Keyword(s):  
Third Trimester ◽  
In Vitro Perfusion ◽  
The Third

Pulmonary endothelial nitric oxide production is developmentally regulated in the fetus and newborn

1993 ◽  
Vol 265 (4) ◽  
pp. H1056-H1063 ◽  
Author(s):  
P. W. Shaul ◽  
M. A. Farrar ◽  
R. R. Magness
Keyword(s):  
Nitric Oxide ◽  
Vascular Resistance ◽  
Pulmonary Arteries ◽  
Late Gestation ◽  
No Production ◽  
Third Trimester ◽  
Developmentally Regulated ◽  
The Third ◽  
Endothelial Nitric Oxide

To define the role of endothelial nitric oxide (NO) in developmental changes in pulmonary vascular resistance and oxygen responsiveness, we determined the ontogeny of endothelial NO production and of oxygen modulation of that process in pulmonary arteries from fetal and newborn lambs. NO production was assessed by measuring endothelium-dependent arterial guanosine 3',5'-cyclic monophosphate synthesis. Basal NO rose two-fold from late gestation to 1 wk of age and another 1.6-fold from 1 to 4 wk. Acetylcholine-stimulated NO also increased 1.6-fold from 1 to 4 wk. The maturational rise in NO was evident at high Po2 in vitro, and it was not modified by L-arginine. This suggests that the developmental increase may alternatively involve enhanced calcium-calmodulin-mediated mechanisms, increased expression of NO synthase, or greater availability of required cofactor(s). With an acute decline in Po2 in vitro from 680 to 150 or 40 mmHg, there was 50-88% attenuation of basal and acetylcholine-stimulated NO late in the third trimester and in the newborn but not early in the third trimester. Parallel studies of mesenteric endothelium revealed postnatal increases in basal and stimulated NO but no decline in NO at lower Po2. Ontogenic changes in endothelial NO production and in oxygen modulation of that process may be involved in the maturational decrease in vascular resistance and the development of oxygen responsiveness in the pulmonary circulation.

Lymphocyte subset distribution and cytokine secretion in third trimester decidua in normal pregnancy and preeclampsia

2003 ◽  
Vol 109 (1) ◽  
pp. 8-15 ◽  
Author(s):  
Jacek R. Wilczyński ◽  
Henryk Tchórzewski ◽  
Małgorzata Banasik ◽  
Ewa Głowacka ◽  
Artur Wieczorek ◽  
...  
Keyword(s):  
Normal Pregnancy ◽  
Lymphocyte Subset ◽  
Cytokine Secretion ◽  
Third Trimester ◽  
Subset Distribution

Maternal parity and functional contractility of human myometrium in vitro in the third trimester of pregnancy

2019 ◽  
Vol 39 (3) ◽  
pp. 439-444 ◽  
Author(s):  
Gillian A. Ryan ◽  
Sarah M. Nicholson ◽  
Denis J. Crankshaw ◽  
John J. Morrison
Keyword(s):  
Human Myometrium ◽  
Third Trimester ◽  
The Third ◽  
Maternal Parity

Alterations of serum resistin in normal pregnancy and pre-eclampsia

2004 ◽  
Vol 108 (1) ◽  
pp. 81-84 ◽  
Author(s):  
Danqing CHEN ◽  
Minyue DONG ◽  
Qin FANG ◽  
Jing HE ◽  
Zhengping WANG ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Normal Pregnancy ◽  
Third Trimester ◽  
Resistin Level ◽  
Blood Samples ◽  
The Third ◽  
Maternal Adaptation ◽  
Serum Resistin Level ◽  
One Way Anova ◽  
Insight Into

Resistin is expressed in human placenta and has been postulated to play a role in regulating energy metabolism in pregnancy. However, changes in serum resistin levels in normal pregnancy and in the setting of pre-eclampsia are far from understood. The purpose of the present study was to clarify the alterations in serum resistin level in normal pregnancy and pre-eclampsia. Blood samples were taken from 28 healthy non-pregnant women, 27 women in the first, 26 in the second and 26 in the third trimesters of normal pregnancy and 25 women with pre-eclampsia. Serum resistin concentrations were determined by using an ELISA, and mean serum resistin levels were compared with one-way ANOVA. Serum resistin levels were not significantly different among non-pregnant women and women in the first and second trimesters of pregnancy (P>0.05 for all). Serum resistin was significantly elevated in the third trimester of normal pregnancy compared with non-pregnant women (P<0.01) and women in the first (P<0.001) and second (P<0.001) trimesters of pregnancy. Serum resistin level was significantly lower in women with pre-eclampsia than women in the third trimester of normal pregnancy (P<0.001), but was comparable with those of non-pregnant women and women in the first and second trimesters of pregnancy (P>0.05 for all). In conclusion, we found an increase in serum resistin in the third trimester of normal pregnancy, but this increase was not present in pre-eclampsia. We postulate that these associations may offer insight into the mechanisms of maternal adaptation to pregnancy and the pathogenesis of pre-eclampsia.

Stroke Volume Recruitability during the Third Trimester of Pregnancy

2017 ◽  
Vol 35 (08) ◽  
pp. 737-740 ◽  
Author(s):  
Sandra Herrera ◽  
Maggie Kuhlmann-Capek ◽  
Sarah Rogan ◽  
Antonio Saad ◽  
George Saade ◽  
...  
Keyword(s):  
Stroke Volume ◽  
Pregnant Women ◽  
Vena Cava ◽  
Normal Pregnancy ◽  
Gravid Uterus ◽  
Third Trimester ◽  
Fluid Bolus ◽  
The Third ◽  
Hemodynamic Variables ◽  
Flat Portion

Objective It is unknown whether the heart operates in the ascending or flat portion of the Starling curve during normal pregnancy. Pregnant women do not respond to the passive leg-raising maneuver secondary to mechanical obstruction of the inferior vena cava by the gravid uterus. Our objective was to evaluate if administration of a fluid bolus increases baseline stroke volume (SV) among healthy pregnant patients during the third trimester. Study Design Healthy pregnant women who underwent elective term cesarean sections were included. A noninvasive cardiac output monitor was used to measure hemodynamic variables at baseline and after administration of a 500-mL crystalloid bolus. Results Forty-five women were included in the study. Fluid administration was associated with a statistically significant increase in SV from a baseline value of 71 ± 11 to 90 ± 19 mL (95% confidence interval [CI]: 13.67–21.49; p < 0.01) and a significant decrease in maternal heart rate from a baseline of 87 ± 9 beats per minute to 83 ± 8 after the fluid bolus (95% CI: −6.81 to −2.78; p = 0.03). No changes in peripheral vascular resistances or any other measured hemodynamic parameters were noted with volume expansion. Conclusion In healthy term pregnancy, the heart operates in the ascending portion of the Starling's curve, rendering it fluid responsive.

Transvaginal sonographic assessment of cervical dynamics during the third trimester of normal pregnancy

1997 ◽  
Vol 76 (2) ◽  
pp. 118-122 ◽  
Author(s):  
Geoffrey M. Brieger ◽  
Xie Hong Ning ◽  
Robert R. Dawkins ◽  
Kong Qiu Ying ◽  
Cai Weng ◽  
...  
Keyword(s):  
Normal Pregnancy ◽  
Third Trimester ◽  
The Third ◽  
Sonographic Assessment

The radioimmunoassay of placental protein 5 and circulating levels in maternal blood in the third trimester of normal pregnancy

1979 ◽  
Vol 95 (3) ◽  
pp. 509-516 ◽  
Author(s):  
B. Obiekwe ◽  
Diana J. Pendlebury ◽  
Y.B. Gordon ◽  
J.G. Grudzinskas ◽  
T. Chard ◽  
...  
Keyword(s):  
Normal Pregnancy ◽  
Maternal Blood ◽  
Third Trimester ◽  
The Third ◽  
Placental Protein ◽  
Circulating Levels
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