Endocrine and Cardiovascular Responses to Corticotropin-Releasing Hormone in Patients with Posttraumatic Stress Disorder: A Role for Atrial Natriuretic Peptide?

2003 ◽  
Vol 47 (2) ◽  
pp. 102-108 ◽  
Author(s):  
Michael Kellner ◽  
Alexander Yassouridis ◽  
Renate Hübner ◽  
Dewleen G. Baker ◽  
Klaus Wiedemann
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Atrial Natriuretic Peptide ◽  
Posttraumatic Stress ◽  
Natriuretic Peptide ◽  
Stress Disorder ◽  
Cardiovascular Responses ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Atrial Natriuretic

scholarly journals CORTICOTROPIN RELEASING HORMONE RECEPTOR 2 (CRHR-2) GENE IS ASSOCIATED WITH DECREASED RISK AND SEVERITY OF POSTTRAUMATIC STRESS DISORDER IN WOMEN

2013 ◽  
Vol 30 (12) ◽  
pp. 1161-1169 ◽  
Author(s):  
Erika J. Wolf ◽  
Karen S. Mitchell ◽  
Mark W. Logue ◽  
Clinton T. Baldwin ◽  
Annemarie F. Reardon ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Hormone Receptor ◽  
Stress Disorder ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone

Modulation of sympathetic activity by corticotropin-releasing hormone and atrial natriuretic peptide

Neuropeptides ◽  
2003 ◽  
Vol 37 (6) ◽  
pp. 362-368 ◽  
Author(s):  
Josef Arlt ◽  
Holger Jahn ◽  
Michael Kellner ◽  
Andreas Ströhle ◽  
Alexander Yassouridis ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Sympathetic Activity ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Atrial Natriuretic

C-type natriuretic peptide exerts stimulatory effects on the corticotropin-releasing hormone-induced secretion of hormones in normal man

1997 ◽  
Vol 136 (4) ◽  
pp. 388-393 ◽  
Author(s):  
Michael Kellner ◽  
Ines Diehl ◽  
Kristina Knaudt ◽  
Cornelius Schüle ◽  
Holger Jahn ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Area Under Curve ◽  
Statistical Significance ◽  
Subjective Effects ◽  
Endocrine Regulation ◽  
Hormone Release ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Atrial Natriuretic

Abstract C-type natriuretic peptide and atrial natriuretic peptide have been reported to bind to distinct receptors and to exert opposing effects on different systems. Although it is known that atrial natriuretic peptide inhibits the corticotropin-releasing hormone-stimulated hormone release in man, the corresponding action of C-type natriuretic peptide has so far not been characterized. We investigated the effects of 30-min infusions of 150 and 300 μg C-type natriuretic peptide on adrenocorticotropin, cortisol, and prolactin release stimulated by 100 μg corticotropin-releasing hormone and on cardiovascular parameters in 8 healthy male volunteers. Compared with placebo, 300 μg C-type natriuretic peptide significantly (P<0·05) enhanced the stimulation of cortisol (area under curve (arbitrary units): 520 ± 35 vs 651 ± 55) and prolactin (area under curve: 29 ± 3 vs 37 ± 5). Adrenocorticotropin levels were increased, but the differences did not reach statistical significance (maximum increment: 27±4 vs 36± 2 pg/ml). C-type natriuretic peptide at a dose of 150 μg had no clear effect on these hormones and C-type natriuretic peptide also produced no cardiovascular or subjective effects. Our data suggest stimulatory effects of C-type natriuretic peptide on corticotropinreleasing hormone-induced hormone release and offer further evidence for a complex role of different natriuretic peptides in endocrine regulation. European Journal of Endocrinology 136 388–393

The corticotropin-releasing hormone test in patients with posttraumatic stress disorder

1989 ◽  
Vol 26 (4) ◽  
pp. 349-355 ◽  
Author(s):  
Mark A. Smith ◽  
Jonathan Davidson ◽  
James C. Ritchie ◽  
Harold Kudler ◽  
Stephen Lipper ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone
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