Parathyroid Hormone Has a Prosclerotic Effect on Vascular Smooth Muscle Cells

2003 ◽  
Vol 26 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Vlado Perkovic ◽  
Timothy D. Hewitson ◽  
Kristen J. Kelynack ◽  
Marina Martic ◽  
Melanie G. Tait ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Parathyroid Hormone ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells

PARATHYROID HORMONE HAS A PROSCLEROTIC EFFECT ON VASCULAR SMOOTH MUSCLE CELLS

Nephrology ◽  
2002 ◽  
Vol 7 (1) ◽  
pp. A69-A69 ◽  
Author(s):  
Vlado Perkovic ◽  
Tim D Hewitson ◽  
Kristen J Kelynack ◽  
Marina Martic ◽  
Melanie G Tait ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Parathyroid Hormone ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells

scholarly journals EBP50 inhibits the anti-mitogenic action of the parathyroid hormone type 1 receptor in vascular smooth muscle cells

2010 ◽  
Vol 49 (6) ◽  
pp. 1012-1021 ◽  
Author(s):  
Gyun Jee Song ◽  
Stacey Barrick ◽  
Kristen L. Leslie ◽  
Brian Sicari ◽  
Nathalie M. Fiaschi-Taesch ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Parathyroid Hormone ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Mitogenic Action

cAMP response of vascular smooth muscle cells to bovine parathyroid hormone

1984 ◽  
Vol 247 (6) ◽  
pp. E822-E826 ◽  
Author(s):  
R. C. Stanton ◽  
S. B. Plant ◽  
D. A. McCarron
Keyword(s):  
Smooth Muscle ◽  
Parathyroid Hormone ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Base Line ◽  
Cellular Mechanisms ◽  
Smooth Muscle Tissue ◽  
Camp Content

Parathyroid hormone (PTH) is a vasodilator of vascular smooth muscle tissue. It has been shown to produce this vasodilation in normotensive and hypertensive laboratory rats. The effect is log dose dependent, maximal at 1 min and persists for 3–5 min. The cellular mechanisms involved in PTH-mediated vasodilation are unknown. In this study, we sought to determine the cellular changes of cAMP after administration of bovine (b)PTH (1–34). cAMP content of vascular smooth muscle cells was measured at 30 s, 1, 3, and 5 min after incubation with synthetic bPTH (1–34). Tissue cAMP content was decreased by 55% at 1 min (4.1 +/- 0.5 pmol/mg protein at time 0 vs. 1.9 +/- 0.2 pmol/mg protein at 1 min, P less than 0.001). After 5 min, cAMP levels returned to base-line values and increased over the next 5–10 min to levels above base line (P less than 0.01). In conclusion, our data suggest that the initial response of vascular smooth muscle cells to short-term incubation with bPTH (1–34) is an acute decrease in cAMP content.

LDL induces parathyroid hormone-related protein expression in vascular smooth muscle cells: Modulation by simvastatin

2008 ◽  
Vol 198 (2) ◽  
pp. 264-271 ◽  
Author(s):  
Jose Luis Martin-Ventura ◽  
Luis Miguel Blanco-Colio ◽  
Cesar Aparicio ◽  
Luis Ortega ◽  
Pedro Esbrit ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Parathyroid Hormone ◽  
Vascular Smooth Muscle ◽  
Protein Expression ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein
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