Verbal Working Memory Deficit in Parkinson’s Disease Subjects

1999 ◽  
Vol 42 (2) ◽  
pp. 90-94 ◽  
Author(s):  
Anita M.S. Graceffa ◽  
Giovanni A. Carlesimo ◽  
Antonella Peppe ◽  
Carlo Caltagirone
Keyword(s):  
Parkinson’S Disease ◽  
Working Memory ◽  
Parkinson's Disease ◽  
Verbal Working Memory ◽  
Memory Deficit

Study of Verbal Working Memory in Patients With Parkinson's Disease.

2005 ◽  
Vol 19 (1) ◽  
pp. 106-114 ◽  
Author(s):  
Brigitte Gilbert ◽  
Sylvie Belleville ◽  
Louis Bherer ◽  
Sylvain Chouinard
Keyword(s):  
Parkinson’S Disease ◽  
Working Memory ◽  
Parkinson's Disease ◽  
Verbal Working Memory

Neuroimaging of Verbal Working Memory in Parkinson's disease

NeuroImage ◽  
2009 ◽  
Vol 47 ◽  
pp. S109
Author(s):  
AH Andersen ◽  
JT Slevin ◽  
CD Smith ◽  
RJ Kryscio ◽  
FA Schmitt ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Working Memory ◽  
Parkinson's Disease ◽  
Verbal Working Memory

The roles of sequencing and verbal working memory in sentence comprehension deficits in Parkinson’s disease

2006 ◽  
Vol 97 (3) ◽  
pp. 243-257 ◽  
Author(s):  
Jesse Hochstadt ◽  
Hiroko Nakano ◽  
Philip Lieberman ◽  
Joseph Friedman
Keyword(s):  
Parkinson’S Disease ◽  
Working Memory ◽  
Parkinson's Disease ◽  
Sentence Comprehension ◽  
Verbal Working Memory

scholarly journals The role of executive processes in working memory deficits in Parkinson’s Disease

2016 ◽  
Vol 47 (1) ◽  
pp. 123-130 ◽  
Author(s):  
Aleksandra Gruszka ◽  
Daniel Bor ◽  
Roger R. Barker ◽  
Edward Necka ◽  
Adrian M. Owen
Keyword(s):  
Parkinson’S Disease ◽  
Working Memory ◽  
Parkinson's Disease ◽  
Spatial Working Memory ◽  
Clinical Symptoms ◽  
Memory Load ◽  
Memory Task ◽  
Verbal Working Memory ◽  
Memory Deficits ◽  
Exact Nature

Abstract Idiopathic Parkinson’s disease (PD) impairs working memory, but the exact nature of this deficit in terms of the underlying cognitive mechanisms is not well understood. In this study patients with mild clinical symptoms of PD were compared with matched healthy control subjects on a computerized battery of tests designed to assess spatial working memory and verbal working memory. In the spatial working memory task, subjects were required to recall a sequence of four locations. The verbal working memory task was methodologically identical except for the modality of the stimuli used, requiring subjects to orally recall a sequence of six digits. In either case, half of the sequences were structured in a way that allowed ‘chunking’, while others were unstructured. This manipulation was designed to dissociate the strategic component of task performance from the memory-load component. Mild medicated patients with PD were impaired only on the structured versions of the verbal working memory tasks. The analogous deficit in the spatial working memory was less pronounced. These findings are in agreement with the hypothesis that working memory deficits in PD reflect mainly the executive component of the tasks and that the deficits may be at least partly modality-independent.

scholarly journals The Neural Correlates of Spatial and Object Working Memory in Elderly and Parkinson’s Disease Subjects

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Silvia P. Caminiti ◽  
Chiara Siri ◽  
Lucia Guidi ◽  
Angelo Antonini ◽  
Daniela Perani
Keyword(s):  
Parkinson’S Disease ◽  
Working Memory ◽  
Parkinson's Disease ◽  
Neural Correlates ◽  
Elderly Subjects ◽  
Task Execution ◽  
Compensatory Mechanisms ◽  
Frontoparietal Network ◽  
Fmri Study ◽  
Comparable Performance

This fMRI study deals with the neural correlates of spatial and objects working memory (SWM and OWM) in elderly subjects (ESs) and idiopathic Parkinson’s disease (IPD). Normal aging and IPD can be associated with a WM decline. In IPD population, some studies reported similar SWM and OWM deficits; others reported a greater SWM than OWM impairment. In the present fMRI research, we investigated whether compensated IPD patients and elderly subjects with comparable performance during the execution of SWM and OWM tasks would present differences in WM-related brain activations. We found that the two groups recruited a prevalent left frontoparietal network when performing the SWM task and a bilateral network during OWM task execution. More specifically, the ESs showed bilateral frontal and subcortical activations in SWM, at difference with the IPD patients who showed a strict left lateralized network, consistent with frontostriatal degeneration in IPD. The overall brain activation in the IPD group was more extended as number of voxels with respect to ESs, suggesting underlying compensatory mechanisms. In conclusion, notwithstanding comparable WM performance, the two groups showed consistencies and differences in the WM activated networks. The latter underline the compensatory processes of normal typical and pathological aging.

The effects of clinical motor variables and medication dosage on working memory in Parkinson’s disease

2013 ◽  
Vol 82 (2) ◽  
pp. 137-145 ◽  
Author(s):  
Ahmed A. Moustafa ◽  
Peter Bell ◽  
Abeer M. Eissa ◽  
Doaa H. Hewedi
Keyword(s):  
Parkinson’S Disease ◽  
Working Memory ◽  
Parkinson's Disease ◽  
Medication Dosage
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