Effect of Natriuretic Peptides on in vitro Stimulated Adrenocorticotropic Hormone Release and Pro-Opiomelanocortin mRNA Expression by the Fetal Rat Pituitary Gland in Late Gestation

2003 ◽  
Vol 59 (3) ◽  
pp. 142-148 ◽  
Author(s):  
D. Chatelain ◽  
J. Lesage ◽  
V. Montel ◽  
A. Chatelain ◽  
S. Deloof
Keyword(s):  
Pituitary Gland ◽  
Mrna Expression ◽  
Natriuretic Peptides ◽  
Adrenocorticotropic Hormone ◽  
Late Gestation ◽  
Hormone Release ◽  
Fetal Rat ◽  
Rat Pituitary

Cyproheptadine and desmethylcyproheptadine directly inhibit the release of adrenocorticotrophin and β-lipotrophin/β-endorphin activity from the neurointermediate lobe of the rat pituitary gland

1983 ◽  
Vol 96 (3) ◽  
pp. 395-400 ◽  
Author(s):  
S. W. J. Lamberts ◽  
E. G. Bons ◽  
P. Uitterlinden ◽  
W. H. Hackeng
Keyword(s):  
Pituitary Gland ◽  
Anterior Pituitary ◽  
Serotonin Receptor ◽  
Direct Action ◽  
Anterior Pituitary Gland ◽  
Hormone Release ◽  
Neurointermediate Lobe ◽  
Rat Pituitary

Cyproheptadine and its metabolite desmethylcyproheptadine were shown to suppress directly the release of adrenocorticotrophin (ACTH) and β-lipotrophin/β-endorphin activity from the neurointermediate lobe of the pituitary gland incubated in vitro. Neither compound affected the release of ACTH from the anterior pituitary gland. Serotonin stimulated the release of ACTH and β-lipotrophin/β-endorphin activity from the neurointermediate lobe, but did not influence the (desmethyl)cyproheptadine-mediated inhibition of hormone release. These results indicate that serotonin and cyproheptadine affect hormone release by the neurointermediate lobe by a direct action. The effect of cyproheptadine, however, might not be exerted by a serotonin receptor.

Role for serotonin3 receptors in the control of adrenocorticotropic hormone release from rat pituitary cell cultures

1995 ◽  
Vol 133 (2) ◽  
pp. 251-254 ◽  
Author(s):  
Aldo E Calogero ◽  
Gyorgy Bagdy ◽  
Nunziatina Burrello ◽  
Pietro Polosa ◽  
Rosario D'Agata
Keyword(s):  
Pituitary Gland ◽  
Receptor Antagonist ◽  
Cell Cultures ◽  
Adrenocorticotropic Hormone ◽  
Pituitary Cell ◽  
Hormone Release ◽  
Mdl 72222 ◽  
Rat Pituitary ◽  
Ics 205 930 ◽  
Acth Release

Calogero AE, Bagdy G, Burrello N, Polosa P. D'Agata R. Role for serotonin3 receptors in the control of adrenocorticotropic hormone release from rat pituitary cell cultures. Eur J Endocrinol 1995;133:251–4. ISSN 0804–4643 Although several serotonin (5-HT) receptor types have been shown capable of stimulating the release of adrenocorticotropic hormone (ACTH) from the pituitary gland, relatively little is known about the role of the 5-HT3 receptor, a receptor that has generated a great deal of interest for its involvement in many behavioral and therapeutic effects. Hence, in this study, we tested the effects of the 5-HT¾ receptor antagonist 3-tropanyl-indole-3-carboxylate (ICS 205-930) and the selective 5-HT3 receptor antagonist 3-tropanyl-3,5-dichlorobenzoate (MDL 72222) on ACTH release stimulated by 5-HT from primary cultures of rat pituitary cells. Subsequently, we evaluated the effects of the selective 5-HT3 receptor agonist 1-(m-chlorophenyl)-biguanide (m-CPBG) on basal, corticotropin-releasing hormone (CRH)- and arginine vasopressin (AVP)-stimulated ACTH release. The maximal stimulatory effect of 5-HT (10−9 mol/l on ACTH release was antagonized by both ICS 205-930 and MDL 72222, suggesting that 5-HT stimulates basal ACTH release through activation of 5-HT3 receptors. Accordingly, m-CPBG stimulated basal ACTH release in a concentration-dependent fashion. In contrast to 5-HT, m-CPBG did not have any effect on CRH-stimulated ACTH release and inhibited AVP-stimulated ACTH release in a concentration-dependent manner. These data suggest that the 5-HT3 receptor is involved in the release of ACTH from the pituitary gland in vitro. Aldo E Calogero, Istituto di Clinica Medica I, Ospedale Garibaldi, Piazza S Maria di Gesú, 95123 Catania, Italy

Potassium, Corticosterone, and Adrenocorticotropic Hormone Release in vitro

Science ◽  
1969 ◽  
Vol 164 (3878) ◽  
pp. 426-426 ◽  
Author(s):  
J. Kraicer ◽  
J. V. Milligan ◽  
J. L. Gosbee ◽  
R. G. Conrad ◽  
C. M. Branson
Keyword(s):  
Adrenocorticotropic Hormone ◽  
Hormone Release ◽  
Release In Vitro

2-HYDROXYOESTRADIOL INHIBITS PROLACTIN RELEASE FROM THE SUPERFUSED RAT PITUITARY GLAND

1981 ◽  
Vol 90 (3) ◽  
pp. 315-322 ◽  
Author(s):  
ELIZABETH A. LINTON ◽  
NICKI WHITE ◽  
OFELIA LIRA DE TINEO ◽  
S. L. JEFFCOATE
Keyword(s):  
Pituitary Gland ◽  
Prolactin Secretion ◽  
Male Rat ◽  
Prolactin Release ◽  
Rat Pituitary ◽  
Lh Release

The effects of 2-hydroxyoestradiol (2OH-OE2), dopamine, oestradiol-17β and 2OH-OE2 plus dopamine on prolactin and LH release from the male rat pituitary gland were examined in vitro. 2-Hydroxyoestradiol reduced prolactin secretion by 51% at 10−10 mol/l and by 34% at 10−7 mol/l, while oestradiol-17β had no effect at these doses. Dopamine alone (5 × 10−7 mol/l) decreased prolactin released by 58%, 2OH-OE2 plus dopamine produced a similar inhibition of 60%. No significant effect on LH release was observed throughout.

ADRENOCORTICOTROPHIC HORMONE IN THE ANTERIOR AND NEUROINTERMEDIATE LOBES OF THE FETAL RAT PITUITARY GLAND

1981 ◽  
Vol 89 (2) ◽  
pp. 181-186 ◽  
Author(s):  
ALAIN CHATELAIN ◽  
J. P. DUPOUY
Keyword(s):  
Pituitary Gland ◽  
Functional Differentiation ◽  
Pars Intermedia ◽  
Adrenocorticotrophic Hormone ◽  
Pars Distalis ◽  
Adult Rats ◽  
Adrenal Cells ◽  
Specific Radioimmunoassay ◽  
Fetal Rat ◽  
Rat Pituitary

The concentration of ACTH in the pars distalis and pars intermedia of the fetal rat hypophysis from days 17–21 of pregnancy was measured with a specific radioimmunoassay and a bioassay using isolated adrenal cells from adult rats. In both lobes of the pituitary gland, a significant correlation was observed between immunoreactive and bioreactive values, expressed as pg equivalents synthetic human 1–39 ACTH per μg protein. In the pars distalis, ACTH concentrations increased steadily from days 17–20 and then remained unchanged to term. At this time they were tenfold higher than on day 17. In the neurointermediate lobe, ACTH was detected only from day 18; the concentration of ACTH increasing between days 18 and 19. At each of the stages of pregnancy examined, the concentration of ACTH in the pars distalis was greater than that in the pars intermedia. These data have demonstrated that ACTH is present in both anterior and neurointermediate lobes of the fetal rat hypophysis, that the functional differentiation of the pars distalis takes place earlier than that of the pars intermedia, and that the concentrations of corticotrophin in the pars distalis and in the pars intermedia have different patterns of development as gestation progresses.

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