Porphyria cutanea tarda, C282Y, H63D and S65C HFE Gene Mutations and Hepatitis C Infection: A Study from Southern France

Dermatology ◽  
2003 ◽  
Vol 206 (3) ◽  
pp. 212-216 ◽  
Author(s):  
Christine Chiavérini ◽  
Gilles Halimi ◽  
Denis Ouzan ◽  
Philippe Halfon ◽  
Jean-Paul Ortonne ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Porphyria Cutanea Tarda ◽  
Gene Mutations ◽  
Hfe Gene ◽  
Hepatitis C Infection ◽  
Southern France ◽  
Hfe Gene Mutations

scholarly journals Porphyria cutanea tarda, hepatitis C, and HFE gene mutations in north america

Hepatology ◽  
1998 ◽  
Vol 27 (6) ◽  
pp. 1661-1669 ◽  
Author(s):  
Herbert L. Bonkovsky ◽  
Maureen Poh-Fitzpatrick ◽  
Neville Pimstone ◽  
Jorge Obando ◽  
Adrian Di Bisceglie ◽  
...  
Keyword(s):  
Hepatitis C ◽  
North America ◽  
Porphyria Cutanea Tarda ◽  
Gene Mutations ◽  
Hfe Gene ◽  
Hfe Gene Mutations

TNF alpha polymorphisms, HFE gene mutations and acquired factors in Italian patients with porphyria cutanea tarda

2002 ◽  
Vol 36 ◽  
pp. 157-158
Author(s):  
Silvia Rossana Fargion ◽  
Paola Dongiovanni ◽  
Luca Valenti ◽  
AnnaLudovica Fracanzani ◽  
Maurizio Sampietro ◽  
...  
Keyword(s):  
Porphyria Cutanea Tarda ◽  
Gene Mutations ◽  
Tnf Alpha ◽  
Hfe Gene ◽  
Hfe Gene Mutations

scholarly journals Effect of HFE gene polymorphism on sustained virological response in patients with chronic hepatitis C and elevated serum ferritin

2012 ◽  
Vol 49 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Silvia Coelho-Borges ◽  
Hugo Cheinquer ◽  
Fernando Herz Wolff ◽  
Nelson Cheinquer ◽  
Luciano Krug ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Sustained Virological Response ◽  
Chronic Hepatitis C ◽  
Serum Ferritin ◽  
Virological Response ◽  
Elevated Serum ◽  
Gene Mutations ◽  
Hfe Gene ◽  
Hfe Gene Mutations

CONTEXT: Abnormal serum ferritin levels are found in approximately 20%-30% of the patients with chronic hepatitis C and are associated with a lower response rate to interferon therapy. OBJECTIVE: To determine if the presence of HFE gene mutations had any effect on the sustained virological response rate to interferon based therapy in chronic hepatitis C patients with elevated serum ferritin. METHODS: A total of 44 treatment naÏve patients with histologically demonstrated chronic hepatitis C, all infected with hepatitis C virus genotype non-1 (38 genotype 3; 6 genotype 2) and serum ferritin above 500 ng/mL were treated with interferon (3 MU, 3 times a week) and ribavirin (1.000 mg, daily) for 24 weeks. RESULTS: Sustained virological response was defined as negative qualitative HCV-RNA more than 24 weeks after the end of treatment. Serum HCV-RNA was measured by qualitative in house polymerase chain reaction with a limit of detection of 200 IU/mL. HFE gene mutation was detected using restriction-enzyme digestion with RsaI (C282Y mutation analysis) and BclI (H63D mutation analysis) in 16 (37%) patients, all heterozygous (11 H63D, 2 C282Y and 3 both). Sustained virological response was achieved in 0 of 16 patients with HFE gene mutations and 11 (41%) of 27 patients without HFE gene mutations (P = 0.002; exact Fisher test). CONCLUSION: Heterozigozity for H63D and/or C282Y HFE gene mutation predicts absence of sustained virological response to combination treatment with interferon and ribavirin in patients with chronic hepatitis C, non-1 genotype and serum ferritin levels above 500 ng/mL.

Porphyria cutanea tarda in the Basque Country: significance of HFE gene mutations and of external factors

2012 ◽  
Vol 32 (10) ◽  
pp. 1597-1597 ◽  
Author(s):  
Agustin Castiella ◽  
Eva Zapata ◽  
Pedro Otazua ◽  
Leire Zubiaurre
Keyword(s):  
Porphyria Cutanea Tarda ◽  
Basque Country ◽  
Gene Mutations ◽  
External Factors ◽  
Hfe Gene ◽  
Hfe Gene Mutations

scholarly journals Hemochromatosis (HFE) Gene Mutations and Response to Chloroquine in Porphyria Cutanea Tarda

2003 ◽  
Vol 139 (3) ◽  
Author(s):  
Ulrich Stölzel ◽  
Erich Köstler ◽  
Detlef Schuppan ◽  
Matthias Richter ◽  
Uwe Wollina ◽  
...  
Keyword(s):  
Porphyria Cutanea Tarda ◽  
Gene Mutations ◽  
Hfe Gene ◽  
Hfe Gene Mutations

Liver steatosis correlates with iron overload but not with HFE gene mutations in chronic hepatitis C

2013 ◽  
Vol 12 (4) ◽  
pp. 377-384 ◽  
Author(s):  
Katarzyna Sikorska ◽  
Piotr Stalke ◽  
Tomasz Romanowski ◽  
Robert Rzepko ◽  
Krzysztof Piotr Bielawski
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Iron Overload ◽  
Chronic Hepatitis C ◽  
Liver Steatosis ◽  
Gene Mutations ◽  
Hfe Gene ◽  
Hfe Gene Mutations
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