Testicular Sertoli Cell Tumours and Relative Sub-Types

2003 ◽  
Vol 70 (3) ◽  
pp. 205-210 ◽  
Author(s):  
Matteo Giglio ◽  
Mauro Medica ◽  
Aldo Franco de Rose ◽  
Francesco Germinale ◽  
Jean Louis Ravetti ◽  
...  
Keyword(s):  
Sertoli Cell ◽  
Sertoli Cell Tumours

NEW VIEWS ON THE HORMONE-PRODUCING MESENCHYMOMAS OF THE OVARIES

1960 ◽  
Vol XXXV (IV) ◽  
pp. 513-517
Author(s):  
W. P. Plate
Keyword(s):  
Granulosa Cell ◽  
Sertoli Cell ◽  
Leydig Cell ◽  
Cell Tumour ◽  
Theca Cell ◽  
Granulosa Cell Tumour ◽  
Sertoli Cell Tumours ◽  
Leydig Cell Tumours

ABSTRACT The hormone-producing mesenchymomas of the ovaries can be divided into androblastomas and gynaecoblastomas. The former are derived from »male« elements, and consist of Sertoli-cell tumours and Leydig-cell tumours. The latter arise from »female« elements and consist of granulosacell tumours and theca-cell tumours. Sertoli-cell tumours and granulosacell tumours produce oestrogens, while Leydig-cell tumours and theca-cell tumours produce oestrogens or androgens. Histologically, androblastomas and gynaecoblastomas are often difficult to distinguish. Since no »female« elements occur in a testicle, a granulosa-cell tumour in a testicle is improbable. Gynandroblastomas, therefore, can only be found in an ovary.

Spermatogenesis and testicular tumours in ageing dogs

Reproduction ◽  
2000 ◽  
pp. 443-452 ◽  
Author(s):  
MA Peters ◽  
DG de Rooij ◽  
KJ Teerds ◽  
I van Der Gaag ◽  
FJ van Sluijs
Keyword(s):  
Sertoli Cell ◽  
Leydig Cell ◽  
Seminiferous Tubules ◽  
Score System ◽  
Testicular Tumours ◽  
Severe Impairment ◽  
Per Se ◽  
Testicular Disease ◽  
Sertoli Cell Tumours ◽  
Leydig Cell Tumours

Spermatogenesis was examined in testes from 74 dogs of various breeds without clinically detected testicular disease. A modified Johnsen score system was used to determine whether spermatogenesis deteriorates with ageing. The diameter of seminiferous tubules was measured in dogs without testicular disease to examine other possible effects of ageing on tubular performance. There appeared to be no relation between age and these variables. The influence of testicular tumours on spermatogenesis was also investigated in both affected and unaffected testes. The testes of 28 dogs with clinically palpable tumours and 21 dogs with clinically non-palpable tumours were investigated. In cases of unilateral occurrence of a tumour, impairment of spermatogenesis was observed only in the affected testis of dogs with clinically detected tumours. Bilateral occurrence of tumours, whether detected clinically or non-clinically, was associated with severe impairment of spermatogenesis. The prevalence of tumours increased during ageing. Eighty-six per cent of the clinically detected and 57% of the non-clinically detected tumours were found in old dogs. Multiple types of tumour and bilateral occurrence were very common. Seminomas and Leydig cell tumours were more frequent than Sertoli cell tumours. It was concluded that spermatogenesis per se did not decrease during ageing in dogs but the occurrence of testicular tumours increased with ageing and affected spermatogenesis significantly, as reflected by a lower Johnsen score.

scholarly journals Bowel incarceration within the vaginal tunic in a three-and-half-year-old bilaterally cryptorchid Lhasa Apso

2021 ◽  
Vol 63 (1) ◽  
Author(s):  
Dorcas Oyueley Kodie ◽  
Noah Segun Oyetayo ◽  
Oladotun Solomon Awoyemi ◽  
Cecelia Omowunmi Oguntoye ◽  
Oghenemega David Eyarefe
Keyword(s):  
Risk Factor ◽  
Sertoli Cell ◽  
Epidural Anaesthesia ◽  
Spermatic Cord ◽  
Abdominal Cavity ◽  
Case Presentation ◽  
Spermatic Cord Torsion ◽  
Left Testicle ◽  
History Of ◽  
Sertoli Cell Tumours

Abstract Background Cryptorchidism in dogs is of clinical concern due to its association with development of Sertoli cell tumours, seminomas and spermatic cord torsion. A patent inguinal ring has been found as a risk factor for peritoneal content migration and inguinal hernias. This study reports a case of bowel migration through a patent inguinal ring in a bilaterally cryptorchid dog and incarceration within the vaginal tunic of the left testicle. Case presentation A three-and-a-half-year-old bilaterally cryptorchid Lhasa Apso with a history of anorexia, vomiting, stranguria and inability to defecate was diagnosed with bowel incarceration in the vaginal tunic of a retained left testicle. Surgery performed under epidural anaesthesia with acepromazine/butorphanol premedication revealed a loop of the colon entrapped in the vaginal tunic of the retained left testicle. The incarcerated bowel was thoroughly examined for viability and repositioned into the abdominal cavity. The inguinal ring was repaired and bilateral cryptorchidectomy performed. Conclusion Cryptorchidectomy in dogs is often considered when there is concern for neoplasm or torsion of retained testes. However, this report suggests that cryptorchidectomy should be considered also to preclude the possibility of bowel obstructive emergencies.

Testicular Neoplasms (Interstitial and Sertoli Cell Tumours) in a Domestic Ferret (Mustela putorius furo)

2011 ◽  
Vol 46 (1) ◽  
pp. 177-180 ◽  
Author(s):  
M Batista-Arteaga ◽  
A Suárez-Bonnet ◽  
M Santana ◽  
T Niño ◽  
R Reyes ◽  
...  
Keyword(s):  
Sertoli Cell ◽  
Testicular Neoplasms ◽  
Mustela Putorius ◽  
Sertoli Cell Tumours ◽  
Mustela Putorius Furo

scholarly journals Expression of Selected Markers in Immunohistochemical Diagnosis of Canine and Human Testicular Tumours

2015 ◽  
Vol 59 (1) ◽  
pp. 99-106
Author(s):  
Rafał Ciaputa ◽  
Marcin Nowak ◽  
Janusz A. Madej ◽  
Izabela Janus ◽  
Elżbieta Górzyńska ◽  
...  
Keyword(s):  
Sertoli Cell ◽  
Von Willebrand Factor ◽  
Leydig Cell ◽  
Chromogranin A ◽  
Testicular Tumours ◽  
Immunohistochemical Diagnosis ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Sertoli Cell Tumours ◽  
Leydig Cell Tumours

Abstract Immunohistochemical profiles of the most common canine testicular tumours, including the Leydig cell tumours, seminomas, and Sertoli cell tumours were analysed, and the results were compared with those obtained in the corresponding types of human testicular neoplasms. The expressions of vimentin, von Willebrand factor (FVIII), chromogranin A, synaptophysin, and MCM3 were quantified. In the case of Sertoli cell tumours, only canine ones were analysed, since this type of tumour is very rarely diagnosed in men. The expression of the analysed proteins in the testicular tumours was similar. The von Willebrand factor exhibited the strongest expression in Leydig cell tumours in dogs and men, while vimentin was expressed more strongly in dogs (96.7% had an intensity at +++) than in men (62.5% had +++) in the Leydigioma. The immunoexpression of MCM3 in seminomas was high in both men and dogs – 90% +++ and 100% +++ respectively. The lack of chromogranin A and synaptophysin was observed in almost 100% of seminomas in men and dogs. This differed from the results obtained for Leydigioma, where chromogranin A was expressed in 70% of dogs at +++ and in 100% of men at ++++. The results may indicate that the antibodies were selected correctly. Their analysis and interpretation provides valuable information concerning the nature of the studied tumours.

THE METABOLISM IN VITRO OF DEHYDROEPIANDROSTERONE AND DEHYDROEPIANDROSTERONE SULPHATE BY SERTOLI CELL TUMOURS OF THE TESTIS OF TWO DOGS WITH CLINICAL SIGNS OF HYPEROESTROGENISM

1968 ◽  
Vol 42 (1) ◽  
pp. 99-107 ◽  
Author(s):  
C. G PIERREPOINT
Keyword(s):  
Sertoli Cell ◽  
Clinical Signs ◽  
Testicular Tissue ◽  
Clinical Findings ◽  
Dehydroepiandrosterone Sulphate ◽  
Normal Testis ◽  
Relative Production ◽  
Dog Testis ◽  
Sertoli Cell Tumours

SUMMARY A comparative study was made of the metabolism in vitro of [4-14C] dehydroepiandrosterone (DHA) and [7α-3H]DHA sulphate by Sertoli cell tumours removed from two dogs with feminization and alopecia, respectively, and by a normal dog testis. The formation of oestrone, oestradiol-17β, oestradiol- 17α and oestriol, from either precursor, was not significantly different in the two tumours from that in the normal testis. The inversion of the relative production of androstenedione and testosterone from DHA by one of the tumours compared with the normal testis is discussed in the light of the clinical findings. The transformation of DHA sulphate to C19 steroids by normal and neoplastic testicular tissue and to testosterone sulphate by the neoplasms is described.

scholarly journals Use of antibodies against LH receptor, 3beta-hydroxysteroid dehydrogenase and vimentin to characterize different types of testicular tumour in dogs

Reproduction ◽  
2001 ◽  
pp. 287-296 ◽  
Author(s):  
MA Peters ◽  
KJ Teerds ◽  
I van der Gaag ◽  
DG de Rooij ◽  
FJ van Sluijs
Keyword(s):  
Sertoli Cell ◽  
Leydig Cell ◽  
Leydig Cells ◽  
Hydroxysteroid Dehydrogenase ◽  
Histological Diagnosis ◽  
Lh Receptor ◽  
Testicular Tumours ◽  
Sertoli Cell Tumours ◽  
Mixed Tumours ◽  
Leydig Cell Tumours

Testicular tumours in dogs are of Sertoli cell, Leydig cell or germinal origin and mixed tumours are also frequently observed. The cellular components of mixed tumours are usually identified by histological examination but sometimes this is difficult. In this study, a panel of specific antibodies was used to identify the different cell types in testicular tumours by immunohistochemistry. Leydig cells were identified using an antibody against the LH receptor and an antibody against the steroidogenic enzyme 3beta-hydroxysteroid dehydrogenase (3beta-HSD), both of which are characteristic of Leydig cells in testes. Sertoli cells were identified using an antibody against the intermediate filament vimentin. Seminoma cells did not stain with any of these antibodies. Vimentin was used only in histologically complex cases. Eighty-six tumours, diagnosed histologically as 29 Sertoli cell tumours, 25 Leydig cell tumours, 19 seminomas and 13 mixed tumours, were studied. Feminization was observed in 17 dogs. Leydig cell tumours stained positively with the antibodies against the LH receptor and 3beta-HSD, whereas seminomas and Sertoli cell tumours were negative (unstained). The antibody against vimentin stained both Sertoli and Leydig cells, and tumours arising from these cells, but not seminomas. Immunohistochemistry revealed that three tumours identified histologically as Sertoli cell tumours were actually Leydig cell tumours. In 14 dogs the histological diagnosis appeared to be incomplete, as mixed tumours instead of pure types of tumours were identified in 11 dogs, and in three dogs mixed tumours appeared to be pure types. Hence, the histological diagnosis was insufficient in approximately 20% of dogs. Furthermore, immunohistochemical analysis of testis tumours revealed that feminization occurred in dogs with Sertoli cell tumours or Leydig cell tumours and their combinations, but not in dogs with a seminoma. In conclusion, incubation with antibodies against LH receptor and 3beta-HSD proved to be a consistently reliable method for identification of Leydig cell tumours in dogs. Vimentin can be used to discriminate between Sertoli cell tumours and seminomas. Overall, this panel of antibodies can be very useful for determination of the identity of testicular tumours in which histological characterization is complicated and the pathogenesis of feminization is not clear.

Two unusual sertoli cell tumours in dogs

1978 ◽  
Vol 88 (3) ◽  
pp. 327-333 ◽  
Author(s):  
B. Hauser ◽  
P. Wild
Keyword(s):  
Sertoli Cell ◽  
Sertoli Cell Tumours
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