Comparison of Conjunctival and Nasal Provocation Test in Allergic Rhinitis to House Dust Mite

2003 ◽  
Vol 130 (1) ◽  
pp. 51-59 ◽  
Author(s):  
Herbert Riechelmann ◽  
Barbara Epple ◽  
Gunther Gropper
Keyword(s):  
Allergic Rhinitis ◽  
House Dust ◽  
House Dust Mite ◽  
Provocation Test ◽  
Nasal Provocation Test ◽  
Nasal Provocation ◽  
Dust Mite

scholarly journals Usefulness of House Dust Mite Nasal Provocation Test in Asthma

2017 ◽  
Vol 9 (2) ◽  
pp. 152 ◽  
Author(s):  
Inseon S. Choi ◽  
Soo-Jeong Kim ◽  
Joo-Min Won ◽  
Myeong-Soo Park
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Provocation Test ◽  
Nasal Provocation Test ◽  
Nasal Provocation ◽  
Dust Mite

scholarly journals Mono-allergic and poly-allergic rhinitis patients have comparable numbers of mucosal Foxp3+CD4+ T lymphocytes

2014 ◽  
Vol 52 (3) ◽  
pp. 260-266
Author(s):  
B. Muller ◽  
S.M. Reinartz ◽  
D. van Egmond ◽  
E.J.J. de Groot ◽  
W.J. Fokkens ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
T Lymphocytes ◽  
House Dust ◽  
House Dust Mite ◽  
Grass Pollen ◽  
Healthy Controls ◽  
Cd4 Cells ◽  
Nasal Provocation ◽  
Dust Mite ◽  
Before And After

Background: We previously found that allergic rhinitis patients with an isolated pollen sensitization responded more strongly to a nasal provocation with grass pollen (GP) than patients who had an additional house dust mite (HDM) sensitization. To elucidate this phenomenon, we investigated the dynamics of Foxp3+CD4+ T lymphocytes in allergic rhinitis patients with distinct allergen sensitizations. Methods: Three groups of allergic rhinitis patients with skin prick test confirmed allergic sensitizations were investigated and compared to 14 healthy controls: 14 subjects with an isolated grass pollen sensitization (Mono-GP); 9 subjects with isolated housedust mite sensitization (Mono-HDM); 29 subjects with grass pollen and house dust mite sensitization (poly-sensitized). Subjects in the Mono-GP group were challenged with grass pollen extract, subjects in the Mono-HDM group were challenged with house dust mite extract, subjects in the poly-sensitized group and the healthy controls were randomly challenged with either grass pollen or house dust mite. Nasal biopsies were taken before and after nasal provocation. We compared the distribution of FoxP3+CD4+ cells in nasal biopsies before and after nasal provocation using immunohistochemistry. Results: There was no difference in the number of FoxP3+CD4+ cells between healthy and the three allergic groups at baseline.Nasal provocation did result in an increase in eosinophils in the three allergic groups, but did not result in a change in the number of FoxP3+CD4+ cells in any of the groups or induced differences between any of the groups. Conclusion: Clinical differences in the response between mono-GP and multiple-sensitized allergic individuals are not related to differences in the number of regulatory T cells in the nasal mucosa.

scholarly journals MP29-02 reduces nasal hyperreactivity and nasal mediators in patients with house dust mite-allergic rhinitis

Allergy ◽  
2018 ◽  
Vol 73 (5) ◽  
pp. 1084-1093 ◽  
Author(s):  
I. Kortekaas Krohn ◽  
I. Callebaut ◽  
Y. A. Alpizar ◽  
B. Steelant ◽  
L. Van Gerven ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
House Dust ◽  
House Dust Mite ◽  
Dust Mite ◽  
Nasal Hyperreactivity

Normal Saline Solution Nasal-Pharyngeal Irrigation Improves Chronic Cough Associated with Allergic Rhinitis

2017 ◽  
Vol 31 (2) ◽  
pp. 96-104 ◽  
Author(s):  
Lin Lin ◽  
Zhongchun Chen ◽  
Yitan Cao ◽  
Guangbin Sun
Keyword(s):  
Allergic Rhinitis ◽  
House Dust ◽  
House Dust Mite ◽  
Chronic Cough ◽  
Saline Solution ◽  
Basic Protein ◽  
Leukotriene C4 ◽  
Major Basic Protein ◽  
Leicester Cough Questionnaire ◽  
Dust Mite

Background Upper airway inflammation is one of the most commonly identified causes of chronic cough, although the underlying mechanism is not clear. This study compared normal saline solution nasal-pharyngeal irrigation (NSNPI) and fluticasone propionate nasal spray (FPNS) treatment for chronic cough associated with allergic rhinitis (AR). Methods Patients with suspected AR to house-dust mite were enrolled, and the symptom of cough was assessed by a cough symptom score and the Leicester Cough Questionnaire, and cough response to capsaicin was evaluated. AR was assessed by using the visual analog scale (VAS) and the Mini Juniper Rhinoconjunctivitis Quality of Life Questionnaire (MiniRQLQ). Mediators, including histamine, leukotriene C4, and prostaglandin D2, and the major basic protein from nasal lavage fluid (NLF) were examined. The patients were treated with NSNPI (the NSNPI group) or FPNS (the FPNS group) for 30 days, after which they were reassessed. Results Forty-five of 50 patients completed this study. The scores of the cough symptom and the Leicester Cough Questionnaire, and the capsaicin cough threshold all improved statistically after NSNPI but did not change after FPNS. There were statistically significant changes in the evaluations of the MiniRQLQ and the mediators, including histamine and leukotriene C4, in the NLF in the NSNPI group. However, significant changes were found in the assessments of VAS, MiniRQLQ, and all above mediators including histamine, leukotriene C4, and prostaglandin D2, and the major basic protein in the NLF of the FPNS group. Furthermore, the assessments of VAS and all the mediators were reduced more in the FPNS group compared with those in the NSNPI group. Conclusion The patients with suspected AR to house-dust mite reported a better relief of the cough symptom after 30 days of treatment with NSNPI compared with that after nasal corticosteroid.

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