scholarly journals Signaling Complex Organization by PDZ Domain Proteins

Neurosignals ◽  
2002 ◽  
Vol 11 (6) ◽  
pp. 315-321 ◽  
Author(s):  
Jing-Song Fan ◽  
Mingjie Zhang
Keyword(s):  
Pdz Domain ◽  
Signaling Complex ◽  
Complex Organization ◽  
Pdz Domain Proteins

scholarly journals PDZ and LIM Domain-Encoding Genes: Molecular Interactions and their Role in Development

2007 ◽  
Vol 7 ◽  
pp. 1470-1492 ◽  
Author(s):  
Aartjan J. W. te Velthuis ◽  
Christoph P. Bagowski
Keyword(s):  
Current Knowledge ◽  
Pdz Domain ◽  
Cell Lineage ◽  
Lim Domain ◽  
Specific Expression ◽  
Cytoskeleton Organization ◽  
Signaling Complex ◽  
Lim Domains ◽  
Gene Structures ◽  
Encoding Genes

PDZ/LIM genes encode a group of proteins that play very important, but diverse, biological roles. They have been implicated in numerous vital processes, e.g., cytoskeleton organization, neuronal signaling, cell lineage specification, organ development, and oncogenesis.In mammals, there are ten genes that encode for both a PDZ domain, and one or several LIM domains: four genes of the ALP subfamily (ALP, Elfin, Mystique, and RIL), three of the Enigma subfamily (Enigma, Enigma Homolog, and ZASP), the two LIM kinases (LIMK1 and LIMK2), and the LIM only protein 7 (LMO7). Functionally, all PDZ and LIM domain proteins share an important trait, i.e., they can associate with and/or influence the actin cytoskeleton.We review here the PDZ and LIM domain—encoding genes and their different gene structures, their binding partners, and their role in development and disease. Emphasis is laid on the important questions: why the combination of a PDZ domain with one or more LIM domains is found in such a diverse group of proteins, and what role the PDZ/LIM module could have in signaling complex assembly and localization.Furthermore, the current knowledge on splice form specific expression and the function of these alternative transcripts during vertebrate development will be discussed, since another source of complexity for the PDZ and LIM domain—encoding proteins is introduced by alternative splicing, which often creates different domain combinations.

scholarly journals Human Papillomavirus E6 interaction with cellular PDZ domain proteins modulates YAP nuclear localization

Virology ◽  
2018 ◽  
Vol 516 ◽  
pp. 127-138 ◽  
Author(s):  
Sydney Webb Strickland ◽  
Nicole Brimer ◽  
Charles Lyons ◽  
Scott B. Vande Pol
Keyword(s):  
Human Papillomavirus ◽  
Nuclear Localization ◽  
Pdz Domain ◽  
Pdz Domain Proteins

Mechanism and role of PDZ domains in signaling complex assembly

2001 ◽  
Vol 114 (18) ◽  
pp. 3219-3231 ◽  
Author(s):  
Baruch Z. Harris ◽  
Wendell A. Lim
Keyword(s):  
Cell Signaling ◽  
Pdz Domain ◽  
Photoreceptor Cells ◽  
Protein Recognition ◽  
Pdz Domains ◽  
Peptide Motifs ◽  
Signaling Complex ◽  
Multicellular Organisms ◽  
Drosophila Photoreceptor

PDZ domains are protein-protein recognition modules that play a central role in organizing diverse cell signaling assemblies. These domains specifically recognize short C-terminal peptide motifs, but can also recognize internal sequences that structurally mimic a terminus. PDZ domains can therefore be used in combination to bind an array of target proteins or to oligomerize into branched networks. Several PDZ-domain-containing proteins play an important role in the transport, localization and assembly of supramolecular signaling complexes. Examples of such PDZ-mediated assemblies exist in Drosophila photoreceptor cells and at mammalian synapses. The predominance of PDZ domains in metazoans indicates that this highly specialized scaffolding module probably evolved in response to the increased signaling needs of multicellular organisms.

Targeting PDZ Domain Proteins for Treating NMDA Receptor-Mediated Excitotoxicity

2006 ◽  
Vol 6 (7) ◽  
pp. 711-721 ◽  
Author(s):  
Wenyu Wen ◽  
Wenning Wang ◽  
Mingjie Zhang
Keyword(s):  
Nmda Receptor ◽  
Pdz Domain ◽  
Pdz Domain Proteins
Sign in / Sign up

Export Citation Format

Share Document