Association of the Vitamin D Receptor Genotype with Bone Metastases in Breast Cancer Patients

Oncology ◽  
2003 ◽  
Vol 64 (2) ◽  
pp. 154-159 ◽  
Author(s):  
Thomas Schöndorf ◽  
Carsten Eisberg ◽  
Gernot Wassmer ◽  
Mathias Warm ◽  
Martina Becker ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Bone Metastases ◽  
Cancer Patients ◽  
Vitamin D Receptor ◽  
Breast Cancer Patients

Evalution of effect of Vitamin D levels and tumor Vitamin D receptor status as a risk factor and marker for therapeutic response Indian breast cancer patients.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e12523-e12523
Author(s):  
Kul Ranjan Singh ◽  
Abhinav Arun Sonkar ◽  
Prarthana Saxena ◽  
Jitendra Kumar Kushwaha ◽  
Akshay Anand Agarwal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Risk Factor ◽  
Cancer Patients ◽  
Vitamin D Receptor ◽  
Therapeutic Response ◽  
Breast Cancer Patients ◽  
Receptor Status ◽  
Vitamin D Levels

Haplotype Analysis of Vitamin D Receptor (VDR) Gene in Breast Cancer Patients

2021 ◽  
Vol 67 (06/2021) ◽  
Author(s):  
Emel Ergul ◽  
Turgay Simsek ◽  
Nihal Uren ◽  
Tugcan Korak ◽  
Hayal Simsek ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Patients ◽  
Vitamin D Receptor ◽  
Haplotype Analysis ◽  
Breast Cancer Patients ◽  
Vdr Gene

scholarly journals Inhibition of Antiestrogen-Promoted Pro-Survival Autophagy and Tamoxifen Resistance in Breast Cancer through Vitamin D Receptor

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1715
Author(s):  
Ye Li ◽  
Katherine L Cook ◽  
Wei Yu ◽  
Lu Jin ◽  
Kerrie B Bouker ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Patients ◽  
Vitamin D Receptor ◽  
Tamoxifen Resistance ◽  
Cancer Recurrence ◽  
Synthetic Analog ◽  
Breast Cancer Patients ◽  
Jnk Pathway ◽  
Estrogen Receptor Positive

We determined how vitamin D receptor (VDR) is linked to disease outcome in estrogen receptor-positive (ER+) breast cancer patients treated with tamoxifen (TAM). Breast cancer patients (n = 581) in four different datasets were divided into those expressing higher (above median) and lower levels of VDR in pretreatment ER+ tumors. Across all datasets, TAM-treated patients with higher pretreatment tumor VDR expression exhibited significantly longer recurrence-free survival. Ingenuity pathway analysis identified autophagy and unfolded protein response (UPR) as top differentially expressed pathways between high and low VDR-expressing ER+ cancers. Activation of VDR with vitamin D (VitD), either calcitriol or its synthetic analog EB1089, sensitized MCF-7-derived, antiestrogen-resistant LCC9 human breast cancer cells to TAM, and attenuated increased UPR and pro-survival autophagy. Silencing of VDR blocked these effects through the IRE1α-JNK pathway. Further, silencing of VDR impaired sensitivity to TAM in antiestrogen-responsive LCC1 cells, and prevented the effects of calcitriol and EB1089 on UPR and autophagy. In a preclinical mouse model, dietary VitD supplementation induced VDR activation and reduced carcinogen-induced ER+ mammary tumor incidence. In addition, IRE1α-JNK signaling was downregulated and survival autophagy was inhibited in mammary tumors of VitD-supplemented mice. Thus, activation of VDR is predictive of reduced risk of breast cancer recurrence in ER+ patients, possibly by inhibiting antiestrogen-promoted pro-survival autophagy.

Bsm1 Gene polymorphism of the vitamin D receptor in breast cancer patients: influence of obesity and relevant drugs

2016 ◽  
Vol 26 (1) ◽  
pp. 127-134 ◽  
Author(s):  
Noha Mohammed Ali Haikal ◽  
Mona Abo-Bakr El-Hussiny ◽  
Omar Farouk ◽  
Ekbal Mohammed Abo Hashem
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Gene Polymorphism ◽  
Cancer Patients ◽  
Vitamin D Receptor ◽  
Breast Cancer Patients

The prognostic value of Vitamin D receptor and its up-stream miR-27b and miR-125a expression in breast cancer patients

Gene Reports ◽  
2021 ◽  
pp. 101121
Author(s):  
AbuSamra Nehal ◽  
Rashad Mona ◽  
Abd ElMoneim Nadia ◽  
Shawky Sanaa ◽  
Kamel Maher
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Patients ◽  
Vitamin D Receptor ◽  
Prognostic Value ◽  
Breast Cancer Patients

scholarly journals Association of Serum Vitamin D Level and Vitamin D Receptor Expression among Newly Diagnosed Breast Cancer

2021 ◽  
Vol 50 (11) ◽  
pp. 3321-3332
Author(s):  
Hani Ajrina Zulkeflee ◽  
Tuan Salwani Tuan Ismail ◽  
Tengku Ahmad Damitri Al-Astani Tengku Din ◽  
Maya Mazuwin Yahya ◽  
Wan Faiziah Wan Abdul Rahman
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Healthy Volunteers ◽  
Cancer Patients ◽  
Vitamin D Receptor ◽  
Receptor Expression ◽  
Cancer Tissue ◽  
Newly Diagnosed ◽  
Breast Cancer Patients ◽  
Vitamin D Levels

There is a mushrooming interest in the anti-carcinogenic property of vitamin D. However, many researches reported a conflicting result in the association of vitamin D levels to certain types of cancer. This study was designed to assess the association between vitamin D and vitamin D receptor (VDR) expression with breast cancer. This case-control study, carried out at Hospital Universiti Sains Malaysia, Kelantan, involved 69 newly diagnosed breast cancer patients and 73 healthy volunteers. Serum 25(OH)D was taken and compared between 2 groups. VDR expression in patients’ breast tissue samples was determined by immunohistochemical staining method using anti-VDR antibody. 85.5% of breast cancer patients and 97.3% of healthy control were vitamin D insufficient with a mean (SD) of 13.36 (6.96) ng/mL and 13.05 (3.71) ng/mL, respectively, and the difference was not statistically significant. VDR expression showed cytoplasmic positivity in 75.4% of breast cancer tissue, followed by both cytoplasmic and nuclear positivity in 21.5% and complete absence in 3%. There was no significant association between VDR expression and hormone receptor status. In conclusion, there was a high prevalence of vitamin D deficiency among breast cancer and healthy volunteers in our study. There was no significant association between breast cancer and vitamin D. The VDR expression in breast cancer cells showed high cytoplasmic localization.

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