Genetics of Mood Disorders: Current Status of Knowledge and Prospects1

2002 ◽  
pp. 35-62
Author(s):  
W. Maier
Keyword(s):  
Mood Disorders ◽  
Current Status

scholarly journals Current Status of Lithium in the Treatment of Mood Disorders

2014 ◽  
Vol 1 (3) ◽  
pp. 294-305 ◽  
Author(s):  
Gin S. Malhi ◽  
Claire McAulay ◽  
Kristina Fritz
Keyword(s):  
Mood Disorders ◽  
Current Status

scholarly journals Comprehensive Bibliometric Analysis of the Kynurenine Pathway in Mood Disorders: Focus on Gut Microbiota Research

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiuqing Zhu ◽  
Jinqing Hu ◽  
Shuhua Deng ◽  
Yaqian Tan ◽  
Chang Qiu ◽  
...  
Keyword(s):  
Immune System ◽  
Gut Microbiota ◽  
Citation Analysis ◽  
Mood Disorders ◽  
Bibliometric Analysis ◽  
The United States ◽  
Kynurenine Pathway ◽  
Current Status ◽  
Future Research ◽  
Low Grade

Background: Emerging evidence implicates the dysregulated kynurenine pathway (KP), an immune-inflammatory pathway, in the pathophysiology of mood disorders (MD), including depression and bipolar disorder characterized by a low-grade chronic pro-inflammatory state. The metabolites of the KP, an important part of the microbiota-gut-brain axis, serve as immune system modulators linking the gut microbiota (GM) with the host central nervous system.Aim: This bibliometric analysis aimed to provide a first glimpse into the KP in MD, with a focus on GM research in this field, to guide future research and promote the development of this field.Methods: Publications relating to the KP in MD between the years 2000 and 2020 were retrieved from the Scopus and Web of Science Core Collection (WoSCC), and analyzed in CiteSpace (5.7 R5W), biblioshiny (using R-Studio), and VOSviewer (1.6.16).Results: In total, 1,064 and 948 documents were extracted from the Scopus and WoSCC databases, respectively. The publications have shown rapid growth since 2006, partly owing to the largest research hotspot appearing since then, “quinolinic acid.” All the top five most relevant journals were in the neuropsychiatry field, such as Brain Behavior and Immunity. The United States and Innsbruck Medical University were the most influential country and institute, respectively. Journal co-citation analysis showed a strong tendency toward co-citation of research in the psychiatry field. Reference co-citation analysis revealed that the top four most important research focuses were “kynurenine pathway,” “psychoneuroimmunology,” “indoleamine 2,3-dioxygenase,” and “proinflammatory cytokines,” and the most recent focus was “gut-brain axis,” thus indicating the role of the KP in bridging the GM and the host immune system, and together reflecting the field’s research foundations. Overlap analysis between the thematic map of keywords and the keyword burst analysis revealed that the topics “Alzheimer’s disease,” “prefrontal cortex,” and “acid,” were research frontiers.Conclusion: This comprehensive bibliometric study provides an updated perspective on research associated with the KP in MD, with a focus on the current status of GM research in this field. This perspective may benefit researchers in choosing suitable journals and collaborators, and aid in the further understanding of the field’s hotspots and frontiers, thus facilitating future research.

scholarly journals Comment on “Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status“

CNS Drugs ◽  
2022 ◽  
Author(s):  
Marco Pappagallo ◽  
Charles E. Inturrisi ◽  
Paolo L. Manfredi
Keyword(s):  
Mood Disorders ◽  
Current Status

scholarly journals Psychomotor Retardation in Depression: A Systematic Review of Diagnostic, Pathophysiologic, and Therapeutic Implications

2013 ◽  
Vol 2013 ◽  
pp. 1-18 ◽  
Author(s):  
Djamila Bennabi ◽  
Pierre Vandel ◽  
Charalambos Papaxanthis ◽  
Thierry Pozzo ◽  
Emmanuel Haffen
Keyword(s):  
Mood Disorders ◽  
Bipolar Depression ◽  
Psychomotor Retardation ◽  
Current Status ◽  
Central Feature ◽  
Therapeutic Implications ◽  
Functional Deficits ◽  
Diagnostic Management ◽  
Depressive Subtypes ◽  
The Individual

Psychomotor retardation is a central feature of depression which includes motor and cognitive impairments. Effective management may be useful to improve the classification of depressive subtypes and treatment selection, as well as prediction of outcome in patients with depression. The aim of this paper was to review the current status of knowledge regarding psychomotor retardation in depression, in order to clarify its role in the diagnostic management of mood disorders. Retardation modifies all the actions of the individual, including motility, mental activity, and speech. Objective assessments can highlight the diagnostic importance of psychomotor retardation, especially in melancholic and bipolar depression. Psychomotor retardation is also related to depression severity and therapeutic change and could be considered a good criterion for the prediction of therapeutic effect. The neurobiological process underlying the inhibition of activity includes functional deficits in the prefrontal cortex and abnormalities in dopamine neurotransmission. Future investigations of psychomotor retardation should help improve the understanding of the pathophysiological mechanisms underlying mood disorders and contribute to improving their therapeutic management.

scholarly journals Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status

CNS Drugs ◽  
2021 ◽  
Author(s):  
Ioline D. Henter ◽  
Lawrence T. Park ◽  
Carlos A. Zarate
Keyword(s):  
Mood Disorders ◽  
Current Status

Current status of special planetary and lunar theories and ephemerides

1966 ◽  
Vol 25 ◽  
pp. 266-267
Author(s):  
R. L. Duncombe
Keyword(s):  
Observational Data ◽  
Current Status ◽  
Numerical Errors

An examination of some specialized lunar and planetary ephemerides has revealed inconsistencies in the adopted planetary masses, the presence of non-gravitational terms, and some outright numerical errors. They should be considered of temporary usefulness only, subject to subsequent amendment as required for the interpretation of observational data.

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