Association between Inducible Nitric Oxide Synthase Expression and p53 Status in Human Esophageal Squamous Cell Carcinoma

Oncology ◽  
2002 ◽  
Vol 64 (1) ◽  
pp. 90-96 ◽  
Author(s):  
Manabu Matsumoto ◽  
Mutsuo Furihata ◽  
Atsushi Kurabayashi ◽  
Keijiro Araki ◽  
Shiro Sasaguri ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Squamous Cell Carcinoma ◽  
Nitric Oxide Synthase ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Inducible Nitric Oxide Synthase ◽  
Squamous Cell ◽  
P53 Status ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

The importance of inducible nitric oxide synthase and nitrotyrosine as prognostic markers for oral squamous cell carcinoma

2019 ◽  
Vol 48 (10) ◽  
pp. 967-975 ◽  
Author(s):  
João Paulo Silva Servato ◽  
Carlos Ueira Vieira ◽  
Paulo Rogério de Faria ◽  
Sérgio Vitorino Cardoso ◽  
Adriano Mota Loyola
Keyword(s):  
Nitric Oxide ◽  
Squamous Cell Carcinoma ◽  
Nitric Oxide Synthase ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Inducible Nitric Oxide Synthase ◽  
Squamous Cell ◽  
Prognostic Markers ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Third Place — Resident Basic Science Award 1995: Immunohistochemical Characterization of Nitric Oxide Synthase Activity in Squamous Cell Carcinoma of the Head and Neck

1995 ◽  
Vol 113 (5) ◽  
pp. 541-549
Author(s):  
Kristina W. Rosbe ◽  
Jiri Prazma ◽  
Peter Petrusz ◽  
Whit Mims ◽  
Steve S. Ball ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Squamous Cell Carcinoma ◽  
Nitric Oxide Synthase ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Inducible Nitric Oxide Synthase ◽  
Squamous Cell ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity ◽  
Inducible Nitric Oxide

This study was designed to investigate the presence of nitric oxide in human squamous cell carcinoma of the head and neck. We localized the activity of nitric oxide synthase in these tumors through immunohistochemical analysis using antibodies to L-citrulline (a byproduct of nitric oxide synthase), to inducible nitric oxide synthase, and to constitutive nitric oxide synthase. We found presence of inducible enzyme in squamous cells throughout these tumors, with the highest intensity staining occurring directly around keratin pearls. Our findings suggest that inducible nitric oxide synthase activity is present in squamous cell carcinomas of the head and neck, leading us to conclude that inducible nitric oxide synthase may play a significant role in tumor growth.

scholarly journals Coexpression of COX-2 and iNOS in Angiogenesis of Superficial Esophageal Squamous Cell Carcinoma

2015 ◽  
Vol 100 (4) ◽  
pp. 733-743 ◽  
Author(s):  
Youichi Kumagai ◽  
Jun Sobajima ◽  
Morihiro Higashi ◽  
Toru Ishiguro ◽  
Minoru Fukuchi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Squamous Cell Carcinoma ◽  
Nitric Oxide Synthase ◽  
Esophageal Squamous Cell Carcinoma ◽  
Inducible Nitric Oxide Synthase ◽  
Squamous Epithelium ◽  
Early Stage ◽  
Cox 2 ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Using immunohistochemical staining, the present study was conducted to examine whether cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) affect angiogenesis in early-stage esophageal squamous cell carcinoma (ESCC). We also analyzed the correlation between these two factors. Cyclooxygenase 2, iNOS, and angiogenesis in early-stage ESCC are unclear. Using 10 samples of normal squamous epithelium, 7 samples of low-grade intraepithelial neoplasia (LGIN), and 45 samples of superficial esophageal cancer, we observed the expression of COX-2 and iNOS. We then investigated the COX-2 and iNOS immunoreactivity scores and the correlation between COX-2 or iNOS scores and microvessel density (MVD) using CD34 or CD105. The intensity of COX-2 or iNOS expression differed significantly according to histological type (P < 0.001). The scores of COX-2 and iNOS were lowest for normal squamous epithelium, followed in ascending order by LGIN, carcinoma in situ and tumor invading the lamina propria mucosae (M1-M2 cancer); and tumor invading the muscularis mucosa (M3) or deeper cancer. The differences were significant (P < 0.001). Cancers classified M1-M2 (P < 0.01 and P < 0.05, respectively); M3; or deeper cancer (P < 0.01) had significantly higher COX-2 and iNOS scores than normal squamous epithelium. There was a significant correlation between COX-2 and iNOS scores (P < 0.001, rs = 0.51). Correlations between COX-2 score and CD34-positive MVD or CD105-positive MVD were significant (rs = 0.53, P < 0.001; rs = 0.62, P < 0.001, respectively). Inducible nitric oxide synthase score was also significantly correlated with CD34 MVD and CD105 MVD (rs = 0.45, P < 0.001; rs = 0.60, P < 0.001, respectively). Chemoprevention of COX-2 or iNOS activity may blunt the development of ESCC from precancerous lesions.

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