The Potential of the Essential Fatty Acid-Deficient Hairless Rat as a Psoriasis Screening Model for Topical Anti-Proliferative Drugs

2002 ◽  
Vol 15 (6) ◽  
pp. 401-413 ◽  
Author(s):  
Monika Jensen ◽  
Lotte Groth ◽  
Gunhild Hølmer ◽  
Harald S. Hansen ◽  
Ann Fullerton
Keyword(s):  
Fatty Acid ◽  
Essential Fatty Acid ◽  
Screening Model ◽  
Essential Fatty Acid Deficient

scholarly journals Formation of Prostaglandin Cyclo-Peroxides and Prostaglandins by Phospholipase A2 in Platelets of Normal and Essential Fatty Acid Deficient Rats

1977 ◽  
Author(s):  
J.E. Vincent ◽  
F.J. Zijlstra
Keyword(s):  
Fatty Acid ◽  
Platelet Aggregation ◽  
Phospholipase A2 ◽  
Essential Fatty Acid ◽  
Essential Fatty Acid Deficient ◽  
Incubation Periods ◽  
Rat Platelets

Phospholipase A2 has a biphasic action upon rat platelet aggregation, enhancing after shorter and inhibiting after longer incubation periods. The first effect is inhibited by indomethacin.Cycloperoxides and thromboxane-like substances and prostaglandins are formed on incubation with the enzyme in the same amounts whether aggregation is induced or not. Formation of cycloperoxides and thromboxanes is not leading to aggregation. Phospholipase A2 enhances the aggregation of the platelets of essential fatty acid deficient rats. Only very small amounts of cycloperoxides and thromboxane-like substances are formed. It is concluded that cycloperoxides and thromboxanes can enhance, but not induce aggregation in rat platelets.

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