Severe acute pancreatitis is related to increased early urinary levels of the activation peptide of pancreatic phospholipase A2

Pancreatology ◽  
2002 ◽  
Vol 2 (6) ◽  
pp. 535-542 ◽  
Author(s):  
Jens M. Mayer ◽  
Michael Raraty ◽  
John Slavin ◽  
Esko Kemppainen ◽  
John Fitzpatrick ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Phospholipase A2 ◽  
Severe Acute Pancreatitis ◽  
Pancreatic Phospholipase ◽  
Pancreatic Phospholipase A2 ◽  
Urinary Levels ◽  
Activation Peptide

Immunoreactive pancreatic phospholipase A2 and catalytically active phospholipases A2 in serum from patients with acute pancreatitis.

1988 ◽  
Vol 34 (6) ◽  
pp. 1052-1054 ◽  
Author(s):  
J U Eskola ◽  
T J Nevalainen ◽  
P Kortesuo
Keyword(s):  
Acute Pancreatitis ◽  
Catalytic Activity ◽  
Phospholipase A2 ◽  
Pla2 Activity ◽  
Serum Samples ◽  
Phospholipases A2 ◽  
Pancreatic Phospholipase ◽  
Pancreatic Phospholipase A2 ◽  
Before And After ◽  
Pla2 Enzyme

Abstract Measuring the content of immunoreactive pancreatic phospholipase A2 (PLA2; EC 3.1.1.4) and the catalytic activity of PLA2 in serum samples from five patients with acute pancreatitis, we found no correlation between these two measurements overall. To test the specificity of the method for catalytic PLA2, we measured PLA2 activity in serum samples before and after immunoadsorption with an antiserum to human pancreatic PLA2. The results suggest the presence of at least two immunologically distinct PLA2 enzyme proteins in sera from these patients. One of the enzymes is pancreatic in origin and may exist in active, inactive, or inhibited form. The activity profile of the second PLA2 enzyme in serum during acute pancreatitis differs from that for other common pancreatic enzymes. In the present experiment, the catalytic activity was not removed by treatment with the anti-human pancreatic PLA2 antiserum. The source of this second PLA2 activity is unknown. Some samples contained increased activities of both PLA2 forms.

Molecular Characterization of Murine Pancreatic Phospholipase A2

2001 ◽  
Vol 20 (3) ◽  
pp. 149-157 ◽  
Author(s):  
Asim K. Mandal ◽  
Zhongjian Zhang ◽  
Janice Y. Chou ◽  
Drazen Zimonjic ◽  
Catherine L. Keck ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Molecular Characterization ◽  
Pancreatic Phospholipase ◽  
Pancreatic Phospholipase A2
Sign in / Sign up

Export Citation Format

Share Document