Production of Monospecific Antibody to Immunodominant Epitopes of the Caprine Arthritis Encephalitis Virus Transmembrane Glycoprotein and Analysis of Their Activity in vitro

Intervirology ◽  
2002 ◽  
Vol 45 (3) ◽  
pp. 177-182 ◽  
Author(s):  
Sophie Dufour ◽  
Marie-Luise Zahno ◽  
Hans-Rudolf Vogt ◽  
Ernst Peterhans ◽  
Giuseppe Bertoni
Keyword(s):  
Encephalitis Virus ◽  
Caprine Arthritis Encephalitis Virus ◽  
Monospecific Antibody ◽  
Transmembrane Glycoprotein ◽  
Immunodominant Epitopes

Systemic and in vitro expression of goat α1-acid glycoprotein during Caprine Arthritis-Encephalitis Virus infection

2009 ◽  
Vol 131 (1-2) ◽  
pp. 50-58 ◽  
Author(s):  
Fabrizio Ceciliani ◽  
Md Mizanur Rahman ◽  
Cristina Lecchi ◽  
Marina Maccalli ◽  
Giuliano Pisoni ◽  
...  
Keyword(s):  
Virus Infection ◽  
Encephalitis Virus ◽  
Caprine Arthritis Encephalitis Virus ◽  
In Vitro Expression ◽  
Acid Glycoprotein

scholarly journals Clearance of a Productive Lentivirus Infection in Calves Experimentally Inoculated with Caprine Arthritis-Encephalitis Virus

2003 ◽  
Vol 77 (11) ◽  
pp. 6430-6437 ◽  
Author(s):  
Thierry Morin ◽  
François Guiguen ◽  
Baya Amel Bouzar ◽  
Stéphanie Villet ◽  
Timothy Greenland ◽  
...  
Keyword(s):  
Blood Cells ◽  
Cytotoxic T Lymphocyte ◽  
Virus Genome ◽  
Encephalitis Virus ◽  
Caprine Arthritis Encephalitis Virus ◽  
Replication Competent Virus ◽  
Target Organs ◽  
New Hosts ◽  
Potential Vaccine

ABSTRACT Lentiviruses have long been considered host-specific pathogens, but several recent observations demonstrated their capacity to conquer new hosts from different species, genera, and families. From these cross-species infections emerged new animal and human infectious diseases. The successful colonization and adaptation of a lentivirus to a nonnatural host depends on unspecific and specific host barriers. Some of those barriers exert a relative control of viral replication (i.e., cytotoxic T-lymphocyte response, viral inhibitory factors), but none of them was found able to totally clear the infection once the retrovirus is fully adapted in its host. In this study we examined the evolution of the host-lentivirus interactions occurring in an experimental animal model of cross-species infection in order to analyze the efficiency of those barriers in preventing the establishment of a persistent infection. Five newborn calves were inoculated with caprine arthritis-encephalitis virus (CAEV), and the evolution of infection was studied for more than 12 months. All the animals seroconverted in the first 0.75 to 1 month following the inoculation and remained seropositive for the remaining time of the experiment. Viral infection was productive during 4 months with isolation of replication competent virus from the blood cells and organs of the early euthanized animals. After 4 months of infection, neither replication-competent virus nor virus genome could be detected in blood cells or in the classical target organs, even after an experimental immunosuppression. No evidence of in vitro restriction of CAEV replication was observed in cells from tissues explanted from organs of these calves. These data provide the demonstration of a natural clearance of lentivirus infection following experimental inoculation of a nonnatural host, enabling perspectives of development of new potential vaccine strategies to fight against lentivirus infections.

scholarly journals Caprine arthritis–encephalitis virus induces apoptosis in infected cells in vitro through the intrinsic pathway

Virology ◽  
2008 ◽  
Vol 375 (2) ◽  
pp. 452-463 ◽  
Author(s):  
Angela Rea-Boutrois ◽  
Guillemette Pontini ◽  
Tim Greenland ◽  
Patrick Mehlen ◽  
Yahia Chebloune ◽  
...  
Keyword(s):  
Encephalitis Virus ◽  
Intrinsic Pathway ◽  
Caprine Arthritis Encephalitis Virus ◽  
Infected Cells

scholarly journals Mammary transmission of caprine arthritis encephalitis virus: a 3D model for in vitro study

2005 ◽  
Vol 45 (4) ◽  
pp. 513-523 ◽  
Author(s):  
Christian Le Jan ◽  
Claire Bellaton ◽  
Timothy Greenland ◽  
Jean-François Mornex
Keyword(s):  
3D Model ◽  
In Vitro Study ◽  
Encephalitis Virus ◽  
Vitro Study ◽  
Caprine Arthritis Encephalitis Virus

Diversity of caprine arthritis–encephalitis virus promoters isolated from goat milk and passaged in vitro

2013 ◽  
Vol 196 (3) ◽  
pp. 431-438 ◽  
Author(s):  
Esperanza Gomez-Lucia ◽  
Joan Rowe ◽  
Carol Collar ◽  
Brian Murphy
Keyword(s):  
Goat Milk ◽  
Encephalitis Virus ◽  
Caprine Arthritis Encephalitis Virus
Sign in / Sign up

Export Citation Format

Share Document