Short-Term Growth Response to GH Treatment and Considerations upon the Limits of Short-Term Growth Predictions

2002 ◽  
Vol 58 (2) ◽  
pp. 71-77 ◽  
Author(s):  
M. Hermanussen ◽  
R. Gausche ◽  
A. Keller ◽  
W. Kiess ◽  
M. Brabec ◽  
...  
Keyword(s):  
Growth Response ◽  
Short Term ◽  
Gh Treatment

scholarly journals THE SHORT-TERM INCREASES OF IGF-I AND IGFBP-3 DURING GH TREATMENT PREDICT THE LONG-TERM GROWTH RESPONSE IN SHORT CHILDREN

1993 ◽  
Vol 33 ◽  
pp. S48-S48
Author(s):  
W F Blum ◽  
S Rosberg ◽  
M B Ranke ◽  
K Albertsson-Wikland
Keyword(s):  
Growth Response ◽  
Short Term ◽  
Gh Treatment ◽  
Short Children ◽  
Igf I ◽  
Igfbp 3

scholarly journals GH TREATMENT IN IDIOPATHIC SHORT STATURE: INFLUENCE OF PUBERTY AND SEX ON SKELETAL MATURATION AND GROWTH RESPONSE

1994 ◽  
Vol 35 (2) ◽  
pp. 263-263
Author(s):  
R L Hintz ◽  
K Attie ◽  
A Johanson ◽  
J Baptista ◽  
J Frane ◽  
...  
Keyword(s):  
Short Stature ◽  
Growth Response ◽  
Idiopathic Short Stature ◽  
Skeletal Maturation ◽  
Gh Treatment

Effects of short-term growth hormone treatment on liver and muscle transcriptomes in rainbow trout (Oncorhynchus mykiss)

2008 ◽  
Vol 32 (3) ◽  
pp. 380-392 ◽  
Author(s):  
Scott A. Gahr ◽  
Roger L. Vallejo ◽  
Gregory M. Weber ◽  
Brian S. Shepherd ◽  
Jeffrey T. Silverstein ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Rate ◽  
Rainbow Trout ◽  
Lipid Metabolism ◽  
Real Time ◽  
Real Time Pcr ◽  
Hormone Receptors ◽  
Target Tissue ◽  
Short Term ◽  
Gh Treatment

Although studies have established that exogenous growth hormone (GH) treatment stimulates growth in fish, its effects on target tissue gene expression are not well characterized. We assessed the effects of Posilac (Monsanto, St. Louis, MO), a recombinant bovine GH, on tissue transcript levels in rainbow trout selected from two high-growth rate and two low-growth rate families. Transcript abundance was measured in liver and muscle with the Genome Research in Atlantic Salmon Project (GRASP) 16K cDNA microarray. A selection of the genes identified as altered by the microarray and transcripts for insulin-like growth factors, growth hormone receptors (GHRs), and myostatins were measured by real-time PCR in the liver, muscle, brain, kidney, intestine, stomach, gill, and heart. In general, transcripts identified as differentially regulated in the muscle on the microarray showed similar directional changes of expression in the other nonhepatic tissues. A total of 114 and 66 transcripts were identified by microarray as differentially expressed with GH treatment across growth rate for muscle and liver, respectively. The largest proportion of these transcripts represented novel transcripts, followed by immune and metabolism-related genes. We have identified a number of genes related to lipid metabolism, supporting a modulation in lipid metabolism following GH treatment. Most notable among the growth-axis genes measured by real-time PCR were increases in GHR1 and -2 transcripts in liver and muscle. Our results indicate that short-term GH treatment activates the immune system, shifts the metabolic sectors, and modulates growth-regulating genes.

scholarly journals Growth Hormone Treatment in Short Children Born Prematurely—Data from KIGS

2011 ◽  
Vol 96 (6) ◽  
pp. 1687-1694 ◽  
Author(s):  
Margaret C. S. Boguszewski ◽  
Hanna Karlsson ◽  
Hartmut A. Wollmann ◽  
Patrick Wilton ◽  
Jovanna Dahlgren
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Growth Response ◽  
Growth Failure ◽  
Hormone Treatment ◽  
Height Velocity ◽  
First Year ◽  
Gh Treatment ◽  
Provocative Test ◽  
Short Children

Context: Children born prematurely with growth failure might benefit from GH treatment. Objectives: The aim was to evaluate the first year growth response to GH treatment in short children born prematurely and to identify predictors of the growth response. Design/Patients: A total of 3215 prepubertal children born prematurely who were on GH treatment were selected from KIGS (The Pfizer International Growth Database), a large observational database. They were classified according to gestational age as preterm (PT; 33 to no more than 37 wk) and very preterm (VPT; <33 wk), and according to birth weight as appropriate for gestational age [AGA; between −2 and +2 sd score (SDS)] and small for gestational age (SGA; −2 SDS or below). Results: Four groups were identified: PT AGA (n = 1928), VPT AGA (n = 629), PT SGA (n = 519), and VPT SGA (n = 139). GH treatment was started at a median age of 7.5, 7.2, 6.7, and 6.0 yr, respectively. After the first year of GH treatment, all four groups presented a significant increase in weight gain and height velocity, with a median increase in height SDS higher than 0.6. Using multiple stepwise regression analysis, 27% of the variation in height velocity could be explained by the GH dose, GH peak during provocative test, weight and age at GH start, adjusted parental height, and birth weight SDS. The first year growth response of the children born PT and SGA could be estimated by the SGA model published previously. Conclusion: Short children born prematurely respond well to the first year of GH treatment. Long-term follow-up is needed.

scholarly journals Consequences of lifetime isolated growth hormone (GH) deficiency and effects of short-term GH treatment on bone in adults with a mutation in the GHRH-receptor gene

2009 ◽  
Vol 70 (1) ◽  
pp. 35-40 ◽  
Author(s):  
Francisco J. A. de Paula ◽  
Miburge B. Góis-Júnior ◽  
Manuel H. Aguiar-Oliveira ◽  
Francisco de A. Pereira ◽  
Carla R. P. Oliveira ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Gh Deficiency ◽  
Receptor Gene ◽  
Short Term ◽  
Gh Treatment ◽  
Ghrh Receptor

scholarly journals Is a Two-Year Growth Response to Growth Hormone Treatment a Better Predictor of Poor Adult Height Outcome Than a First-Year Growth Response in Prepubertal Children With Growth Hormone Deficiency?

2021 ◽  
Vol 12 ◽  
Author(s):  
Saartje Straetemans ◽  
Raoul Rooman ◽  
Jean De Schepper
Keyword(s):  
Growth Hormone ◽  
Growth Response ◽  
Adult Height ◽  
Poor Response ◽  
Hormone Treatment ◽  
Hormone Deficiency ◽  
First Year ◽  
Gh Treatment ◽  
Height Gain ◽  
Design And Methods

ObjectiveThe first year response to growth hormone (GH) treatment is related to the total height gain in GH treated children, but an individual poor first year response is a weak predictor of a poor total GH effect in GH deficient (GHD) children. We investigated whether an underwhelming growth response after 2 years might be a better predictor of poor adult height (AH) outcome after GH treatment in GHD children.Design and methodsHeight data of GHD children treated with GH for at least 4 consecutive years of which at least two prepubertal and who attained (near) (n)AH were retrieved from the Belgian Register for GH treated children (n = 110, 63% boys). In ROC analyses, the change in height (ΔHt) SDS after the first and second GH treatment years were tested as predictors of poor AH outcome defined as: (1) nAH SDS <−2.0, or (2) nAH SDS minus mid-parental height SDS <−1.3, or (3) total ΔHt SDS <1.0. The cut-offs for ΔHt SDS and its sensitivity at a 95% specificity level to detect poor AH outcome were determined.ResultsEleven percent of the cohort had a total ΔHt SDS <1.0. ROC curve testing of first and second years ΔHt SDS as a predictor for total ΔHt SDS <1.0 had an AUC >70%. First-year ΔHt SDS <0.41 correctly identified 42% of the patients with poor AH outcome at a 95% specificity level, resulting in respectively 5/12 (4.6%) correctly identified poor final responders and 5/98 (4.5%) misclassified good final responders (ratio 1.0). ΔHt SDS after 2 prepubertal years had a cut-off level of 0.65 and a sensitivity of 50% at a 95% specificity level, resulting in respectively 6/12 (5.5%) correctly identified poor final responders and 5/98 (4.5%) misclassified good final responders (ratio 1.2).ConclusionIn GHD children the growth response after 2 prepubertal years of GH treatment did not meaningfully improve the prediction of poor AH outcome after GH treatment compared to first-year growth response parameters. Therefore, the decision to re-evaluate the diagnosis or adapt the GH dose in case of poor response after 1 year should not be postponed for another year.

The response of lupins to waterlogging

1976 ◽  
Vol 16 (81) ◽  
pp. 549 ◽  
Author(s):  
P Broue ◽  
DR Marshall ◽  
J Munday
Keyword(s):  
Root System ◽  
Vegetative Growth ◽  
Growth Response ◽  
Short Term ◽  
Controlled Environments

The growth response of species and lines of lupin (Lupinus spp.) to short-term flooding of the root system during vegetative growth was measured in glasshouse and controlled environments. L. luteus was consistently more flood tolerant than L. albus, L. angustifolius and L. mutabilis. Some data showed also that lines within species may vary in their response to flooding but the differences among lines were less marked than those among species.

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