Trioxsalen in the Presence of UVA Is Able to Induce Nuclear Factor kappa B Binding Activity in HaCaT Keratinocytes

2002 ◽  
Vol 15 (5) ◽  
pp. 335-341 ◽  
Author(s):  
H. Sánchez Ruderisch ◽  
C. Schwarz ◽  
J. Shang ◽  
B. Tebbe
Keyword(s):  
Nuclear Factor Kappa B ◽  
Binding Activity ◽  
Nuclear Factor ◽  
Hacat Keratinocytes ◽  
Nuclear Factor Kappa

scholarly journals Ionizing radiation induces expression and binding activity of the nuclear factor kappa B.

1991 ◽  
Vol 88 (2) ◽  
pp. 691-695 ◽  
Author(s):  
M A Brach ◽  
R Hass ◽  
M L Sherman ◽  
H Gunji ◽  
R Weichselbaum ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Nuclear Factor Kappa B ◽  
Binding Activity ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

scholarly journals Progesterone Prevents Traumatic Brain Injury-Induced Intestinal Nuclear Factor kappa B Activation and Proinflammatory Cytokines Expression in Male Rats

2007 ◽  
Vol 2007 ◽  
pp. 1-7 ◽  
Author(s):  
Gang Chen ◽  
Jinxin Shi ◽  
Yasuo Ding ◽  
Hongxia Yin ◽  
Chunhua Hang
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Proinflammatory Cytokines ◽  
Nuclear Factor Kappa B ◽  
Mucosal Injury ◽  
Therapeutic Benefit ◽  
Binding Activity ◽  
Male Rats ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

We have previously shown that traumatic brain injury (TBI) can induce an upregulation of nuclear factor kappa B (NF-κB) and proinflammatory cytokines in the gut, which play an important role in the pathogenesis of acute gut mucosal injury mediated by inflammation. In this work, we investigated whether progesterone administration modulated intestinal NF-κB activity and proinflammatory cytokines expression after TBI in male rats. As a result, we found that administration of progesterone following TBI could decrease NF-κB binding activity, NF-κB p65 protein expression, and concentrations of interleukin-1β(IL-1β), and tumor necrosis factor-α(TNF-α) in the gut. TBI-induced damages of gut structure were ameliorated after progesterone injections. The results of the present study suggest that the therapeutic benefit of post-TBI progesterone injections might be due to its inhibitory effects on intestinal NF-κB activation and proinflammatory cytokines expression.

The role of nuclear factor-[kappa ]B in the biology and treatment of multiple myeloma

2001 ◽  
Vol 28 (6) ◽  
pp. 626-633 ◽  
Author(s):  
James R. Berenson ◽  
Hongjin M. Ma ◽  
Robert Vescio
Keyword(s):  
Multiple Myeloma ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

L-Tetrahydropalmatine Inhibits the Progression of Glioblastoma Tumor by Suppressing the Extracellular-Signal-Regulated Kinase/Nuclear Factor-Kappa B Signaling Pathway

2020 ◽  
Vol 19 (2) ◽  
pp. 164-171
Author(s):  
Feng Xue ◽  
Tingting Chen
Keyword(s):  
Glioblastoma Multiforme ◽  
Nuclear Factor Kappa B ◽  
Matrix Metalloproteinase 2 ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Extracellular Signal ◽  
Apoptosis Protein ◽  
Endothelial Growth Factor

Glioblastoma multiforme is the most common malignancy of central nervous system. Herein we have evaluated the effect of L-tetrahydropalmatine, an isoquinoline alkaloid, on the tumor growth both in vivo and in vitro using C6 glioblastoma multiforme cells and BALB/c mice injected subcutaneously with C6/luc2 cells. The results of these studies show that L-tetrahydropalmatine exhibited cytotoxic effect on C6 glioblastoma multiforme cells, suppressed nuclear factor-kappa B activity, suppressed the levels of tumor-linked proteins such as matrix metalloproteinase-2/9, Cyclin-D1, vascular endothelial growth factor, and X-linked inhibitor of apoptosis protein via ERK/nuclear factor-kappa B cascade. Further, L-tetrahydropalmatine inhibited the cell migration and invasion properties of C6 cells, and also suppressed the tumor weight and volume in mice. Immunohistochemical staining of tumor tissues suggested that L-tetrahydropalmatine inhibited the extracellular-signal-regulated kinase/nuclear factor-kappa B cascade and suppressed the levels of Cyclin-D1; matrix metalloproteinase-2/9; X-linked inhibitor of apoptosis protein; and vascular endothelial growth factor, and also the progression and growth of glioblastoma multiforme in mice. In summary, L-tetrahydropalmatine inhibits the ERK/nuclear factor-kappa B cascade, decreases the tumor volume, and inhibits the proteins responsible for tumor growth both in vivo and in vitro.

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