Effect of Helicobacter pylori Infection on the Activity of Class I, III and IV Alcohol Dehydrogenase in the Human Stomach

Digestion ◽  
2002 ◽  
Vol 66 (1) ◽  
pp. 14-18 ◽  
Author(s):  
L. Chrostek ◽  
W. Jelski ◽  
M. Szmitkowski ◽  
W. Laszewicz
Keyword(s):  
Helicobacter Pylori ◽  
Alcohol Dehydrogenase ◽  
Human Stomach ◽  
Class I

scholarly journals The upstream stimulatory factor binds to and activates the promoter of the rat class I alcohol dehydrogenase gene

1991 ◽  
Vol 266 (23) ◽  
pp. 15457-15463 ◽  
Author(s):  
J.J. Potter ◽  
D. Cheneval ◽  
C.V. Dang ◽  
L.M. Resar ◽  
E. Mezey ◽  
...  
Keyword(s):  
Alcohol Dehydrogenase ◽  
Class I ◽  
Upstream Stimulatory Factor ◽  
Dehydrogenase Gene ◽  
Stimulatory Factor

Helicobacter pylori infection induces a decrease in immunoreactive-somatostatin concentrations of human stomach

1992 ◽  
Vol 37 (3) ◽  
pp. 409-416 ◽  
Author(s):  
Hiroshi Kaneko ◽  
Koichi Nakada ◽  
Terunori Mitsuma ◽  
Kiyoshi Uchida ◽  
Atsushi Furusawa ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Human Stomach ◽  
Helicobacter Pylori Infection

scholarly journals Mutational Analysis of Metronidazole Resistance in Helicobacter pylori

2005 ◽  
Vol 49 (3) ◽  
pp. 1236-1237 ◽  
Author(s):  
Jill M. Moore ◽  
Nina R. Salama
Keyword(s):  
Helicobacter Pylori ◽  
Mutational Analysis ◽  
Transposon Mutagenesis ◽  
Human Stomach ◽  
Metronidazole Resistance ◽  
H Pylori ◽  
Chromosomal Loci

ABSTRACT Metronidazole is one of a few antibiotics effective in eliminating Helicobacter pylori infection of the human stomach. Several chromosomal loci have been implicated in resistance to this drug. Saturation transposon mutagenesis of the H. pylori genome revealed inactivation of the rdxA gene as uniquely able to confer metronidazole resistance.

Class III human liver alcohol dehydrogenase: a novel structural type equidistantly related to the class I and class II enzymes

Biochemistry ◽  
1988 ◽  
Vol 27 (4) ◽  
pp. 1132-1140 ◽  
Author(s):  
Rudolf Kaiser ◽  
Barton Holmquist ◽  
John Hempel ◽  
Bert L. Vallee ◽  
Hans Jörnvall
Keyword(s):  
Alcohol Dehydrogenase ◽  
Human Liver ◽  
Structural Type ◽  
Class Ii ◽  
Class I ◽  
Class Iii ◽  
Liver Alcohol Dehydrogenase

Acid Acclimation byHelicobacter pylori

Physiology ◽  
2005 ◽  
Vol 20 (6) ◽  
pp. 429-438 ◽  
Author(s):  
George Sachs ◽  
David L. Weeks ◽  
Yi Wen ◽  
Elizabeth A. Marcus ◽  
David R. Scott ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Carbonic Anhydrase ◽  
Human Stomach ◽  
Peptic Ulcers ◽  
Acidic Media ◽  
Gram Negative ◽  
Urea Channel ◽  
Acid Acclimation ◽  
Unique Ability

Helicobacter pylori is a Gram-negative neutralophile associated with peptic ulcers and gastric cancer. It has a unique ability to colonize the human stomach by acid acclimation. It uses the pH-gated urea channel, UreI, to enhance urea access to intrabacterial urease and a membrane-anchored periplasmic carbonic anhydrase to regulate periplasmic pH to ~6.1 in acidic media, whereas other neutralophiles cannot regulate periplasmic pH and thus only transit the stomach.

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