Artificial Oxygen Carriers – a Critical Analysis

2002 ◽  
Vol 29 (3) ◽  
pp. 167-174 ◽  
Author(s):  
S. Dinkelmann ◽  
H. Northoff
Keyword(s):  
Critical Analysis ◽  
Oxygen Carriers ◽  
Artificial Oxygen Carriers

Translational research of hemoglobin vesicles as a transfusion alternative

2021 ◽  
Vol 28 ◽  
Author(s):  
Hiromi Sakai ◽  
Naoko Kobayashi ◽  
Tomoko Kure ◽  
Chie Okuda
Keyword(s):  
Blood Donation ◽  
Biologic Agent ◽  
Oxygen Carriers ◽  
Peripheral Tissues ◽  
Beneficial Effects ◽  
Phenothiazine Dyes ◽  
Artificial Oxygen Carriers ◽  
Donated Blood ◽  
Electron Mediators ◽  
Anti Inflammation

: Clinical situations arise in which blood for transfusion becomes scarce or unavailable. Considerable demand for a transfusion alternative persists because of various difficulties posed by blood donation and transfusion systems. Hemoglobin-vesicles (HbV) are artificial oxygen carriers being developed for use as a transfusion alternative. Just as biomembranes of red blood cells (RBCs) do, phospholipid vesicles (liposomes) for Hb encapsulation can protect the human body from toxic effects of molecular Hb. The main HbV component, Hb, is obtained from discarded human donated blood. Therefore, HbV can be categorized as a biologic agent targeting oxygen for peripheral tissues. The purification procedure strictly eliminates the possibility of viral contamination. It also removes all concomitant unstable enzymes present in RBC for utmost safety from infection. The deoxygenated HbVs, which are storable for over years at ambient temperature, can function as an alternative to blood transfusion for resuscitation from hemorrhagic shock and O2 therapeutics. Moreover, a recent study clarified beneficial effects for anti-oxidation and anti-inflammation by carbon monoxide (CO)-bound HbVs. Autoxidation of HbV (HbO2 → metHb + O2-.) is unavoidable after intravenous administration. Co-injection of methylene blue can extract the intraerythrocytic glycolytic electron energy effectively and reduce metHb. Other phenothiazine dyes can also function as electron mediators to improve the functional life span of HbV. This review paper summarizes recent progress of the research and development of HbV, aimed at clinical applications.

scholarly journals Manipulating hemoglobin oxygenation using silica nanoparticles: a novel prospect for artificial oxygen carriers

2018 ◽  
Vol 2 (2) ◽  
pp. 90-94 ◽  
Author(s):  
Stéphanie Devineau ◽  
Laurent Kiger ◽  
Frédéric Galacteros ◽  
Véronique Baudin-Creuza ◽  
Michael Marden ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Sickle Cell ◽  
Rational Design ◽  
Oxygen Carriers ◽  
Key Points ◽  
Tetrameric Structure ◽  
Artificial Oxygen Carriers ◽  
Hemoglobin Oxygenation ◽  
The Way

Key Points Silica nanoparticles act as an effector for human native and sickle cell hemoglobin while preserving their tetrameric structure. Manipulating hemoglobin oxygenation using nanoparticles opens the way for the rational design of hemoglobin-based oxygen carriers.

scholarly journals Artificial Oxygen Carriers

2017 ◽  
Vol 41 (4) ◽  
pp. 311-311 ◽  
Author(s):  
Paul S. Malchesky
Keyword(s):  
Oxygen Carriers ◽  
Artificial Oxygen Carriers

Artificial oxygen carriers and red blood cell substitutes

2019 ◽  
Vol 87 ◽  
pp. S48-S58 ◽  
Author(s):  
Christopher Bialas ◽  
Christopher Moser ◽  
Carrie A. Sims
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Oxygen Carriers ◽  
Artificial Oxygen Carriers

Review of Hemoglobin-Vesicles as Artificial Oxygen Carriers

2009 ◽  
Vol 33 (2) ◽  
pp. 139-145 ◽  
Author(s):  
Hiromi Sakai ◽  
Keitaro Sou ◽  
Hirohisa Horinouchi ◽  
Koichi Kobayashi ◽  
Eishun Tsuchida
Keyword(s):  
Oxygen Carriers ◽  
Artificial Oxygen Carriers

Artificial oxygen carriers for trauma: myth or reality?

2004 ◽  
Vol 65 (10) ◽  
pp. 582-588 ◽  
Author(s):  
Colin F Mackenzie ◽  
Cyndi Bucci
Keyword(s):  
Oxygen Carriers ◽  
Artificial Oxygen Carriers
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