Wall Shear Stress Assessment in the Common Carotid Artery of End-Stage Renal Failure Patients

Nephron ◽  
2002 ◽  
Vol 92 (3) ◽  
pp. 557-563 ◽  
Author(s):  
S.K. Samijo ◽  
R. Barkhuysen ◽  
J.M. Willigers ◽  
K.M.L. Leunissen ◽  
L.A.F. Ledoux ◽  
...  
Keyword(s):  
Renal Failure ◽  
Shear Stress ◽  
Carotid Artery ◽  
Wall Shear Stress ◽  
Common Carotid Artery ◽  
Stress Assessment ◽  
End Stage Renal Failure ◽  
The Common ◽  
Wall Shear ◽  
End Stage

NIDDM is associated with lower wall shear stress of the common carotid artery

Diabetes ◽  
1999 ◽  
Vol 48 (1) ◽  
pp. 193-197 ◽  
Author(s):  
C. Irace ◽  
C. Carallo ◽  
A. Crescenzo ◽  
C. Motti ◽  
M. S. De Franceschi ◽  
...  
Keyword(s):  
Shear Stress ◽  
Carotid Artery ◽  
Wall Shear Stress ◽  
Common Carotid Artery ◽  
Lower Wall ◽  
The Common ◽  
Wall Shear

P36 NIDDM is associated with lower wall shear stress of the common carotid artery

1999 ◽  
Vol 145 ◽  
pp. S20 ◽  
Author(s):  
C Irace ◽  
C Carallo ◽  
MS De Franceschi ◽  
M Ciarnei ◽  
PL Mattioli ◽  
...  
Keyword(s):  
Shear Stress ◽  
Carotid Artery ◽  
Wall Shear Stress ◽  
Common Carotid Artery ◽  
Lower Wall ◽  
The Common ◽  
Wall Shear

Basic study on estimation method of wall shear stress in common carotid artery using blood flow imaging

2020 ◽  
Vol 59 (SK) ◽  
pp. SKKE16 ◽  
Author(s):  
Ryo Nagaoka ◽  
Kazuma Ishikawa ◽  
Michiya Mozumi ◽  
Magnus Cinthio ◽  
Hideyuki Hasegawa
Keyword(s):  
Blood Flow ◽  
Shear Stress ◽  
Carotid Artery ◽  
Wall Shear Stress ◽  
Common Carotid Artery ◽  
Estimation Method ◽  
Flow Imaging ◽  
Basic Study ◽  
Blood Flow Imaging ◽  
Wall Shear

scholarly journals Reproducibility of wall shear stress assessment with the paraboloid method in the internal carotid artery with velocity encoded MRI in healthy young individuals

2007 ◽  
Vol 26 (3) ◽  
pp. 598-605 ◽  
Author(s):  
Frieke M.A. Box ◽  
Rob J. van der Geest ◽  
Jeroen van der Grond ◽  
Matthias J.P. van Osch ◽  
Aeilko H. Zwinderman ◽  
...  
Keyword(s):  
Shear Stress ◽  
Carotid Artery ◽  
Wall Shear Stress ◽  
Internal Carotid Artery ◽  
Internal Carotid ◽  
Stress Assessment ◽  
Wall Shear

Wall Shear Stress Measurement by Ultrafast Vector Flow Imaging for Atherosclerotic Carotid Stenosis

2019 ◽  
Author(s):  
Guillaume Goudot ◽  
Jonathan Poree ◽  
Olivier Pedreira ◽  
Lina Khider ◽  
Pierre Julia ◽  
...  
Keyword(s):  
Shear Stress ◽  
Carotid Artery ◽  
Wall Shear Stress ◽  
Carotid Stenosis ◽  
Common Carotid Artery ◽  
Frame Rate ◽  
Carotid Artery Plaque ◽  
Local Flow ◽  
Linear Probe ◽  
Wall Shear

Objective Carotid plaque vulnerability assessment could guide the decision to perform endarterectomy. Ultrafast ultrasound imaging (UF) can evaluate local flow velocities over an entire 2D image, allowing measurement of the wall shear stress (WSS). We aimed at evaluating the feasibility of WSS measurement in a prospective series of patients with carotid stenosis. Methods UF acquisitions, performed with a linear probe, had an effective frame rate of 5000 Hz. The flow velocity was imaged over the entire plaque area. WSS was computed with the vector field speed using the formula: with the blood velocity and μ, the blood viscosity. The WSS measurement method was validated using a calibrated phantom. In vivo, WSS was analyzed in 5 areas of the carotid wall: common carotid artery, plaque ascent, plaque peak, plaque descent, internal carotid artery. Results Good correlation was found between in vitro measurement and the theoretical WSS values (R2 = 0.95; p < 0.001). 33 patients were prospectively evaluated, with a median carotid stenosis degree of 80 % [75–85]. The maximum WSS value over the cardiac cycle follows the shape of the plaque with an increase during the ascent, reaching its maximum value of 3.25 Pa [2.26–4.38] at the peak of the plaque, and a decrease after passing of the peak (0.93 Pa [0.80–1.19]) lower than the WSS values in the non-stenotic areas (1.47 Pa [1.12–1.77] for the common carotid artery). Conclusion UF allowed local and direct evaluation of the plaque’s WSS, thus better characterizing local hemodynamics to identify areas of vulnerability. Key Points: 

3041Wall shear stress measurement by ultrafast vector flow imaging for atherosclerotic carotid stenosis

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
G Goudot ◽  
L Khider ◽  
O Pedreira ◽  
J M Poree ◽  
P Julia ◽  
...  
Keyword(s):  
Shear Stress ◽  
Carotid Artery ◽  
Wall Shear Stress ◽  
Internal Carotid Artery ◽  
Carotid Stenosis ◽  
Common Carotid Artery ◽  
Carotid Plaque ◽  
Internal Carotid ◽  
Plaque Vulnerability ◽  
Wall Shear

Abstract Background Carotid plaque vulnerability assessment is an important factor in guiding the decision to treat significant carotid stenosis. Ultrafast Ultrasound Imaging (UF) offers the possibility of evaluating local flow velocities over an entire 2D image, allowing access to velocity measurements in contact with the arterial wall and to measure the wall shear stress (WSS). Purpose To evaluate the feasibility of WSS measurement in a prospective series of patients with carotid stenosis. Methods A 7.5 MHz linear probe of an Aixplorer scanner was used. UF acquisitions had 3 tilted plane waves transmits (−10; 0; 10°) and an effective frame rate of 5000Hz. We evaluated the flow velocity in 5 areas of the carotid wall: common carotid artery (1), plaque ascent (2), plaque peak (3), plaque descent (4), internal carotid artery (5) (Figure). WSS was computed with the vector field speed using the following formula, WSS=μ·δn·v with v the blood velocity, n the normal vector to the vessel wall and μ, the blood viscosity, calculated from the hematocrit value for each patient. WSS measurement method was first validated using a laminar flow phantom and known viscosity. And then, 33 patients were then prospectively evaluated, with a median carotid stenosis degree of 80% [75–85]. Results Significant correlation was found between in vitro measurement and the theoretical WSS values (R2=0.95; p<0.001).In patients,the maximum WSS value over the cardiac cycle follows the shape of the plaque with an increase during the ascend, reaching its maximum value of 3.57 Pa [2.47–4.45] at the peak of the plaque, and a fall after passing the peak (0.99 Pa [0.8–1.32]) lower than the WSS values in the non-stenotic areas (1.55 Pa [1.13–1.90] for the common carotid artery) (Table). Table 1 Wall's area Wall shear stress (Pa) Min Max Delta 1. Common carotid artery 0.14 [0.05–0.27] 1.55 [1.13–1.90] 0.73 [0.55–0.96] 2. Plaque's ascent 0.39 [0.24–0.59] 2.63 [1.89–3.28] 1.20 [0.89–1.79] 3. Plaque's peak 0.60 [0.32–0.89] 3.57 [2.47–4.45] 1.78 [1.44–2.46] 4. Plaque's descent 0.16 [0.13–0.22] 0.99 [0.80–1.32] 0.52 [0.34–0.73] 5. Internal carotid artery 0.17 [0.13–0.35] 1.37 [1.04–1.75] 0.72 [0.50–0.87] Results are median [25th–75th percentile]. Figure 1 Conclusion UF provide reliable WSS values. High WSS was present at the peak of the plaque, whereas lowest WSS values were found at the post-stenotic zone. WSS evaluation may help to better characterize the carotid plaque vulnerability.

scholarly journals Multiscale Modeling of Endothelium Derived Wall Shear Stress Regulation in Common Carotid Artery

2019 ◽  
Vol 35 (6) ◽  
pp. 901-914
Author(s):  
Saeed Siri ◽  
Malikeh Nabaei ◽  
Nasser Fatouraee
Keyword(s):  
Mechanical Properties ◽  
Shear Stress ◽  
Carotid Artery ◽  
Wall Shear Stress ◽  
Common Carotid Artery ◽  
3D Model ◽  
Stable Condition ◽  
Patient Specific ◽  
Local Flow ◽  
Wall Shear

ABSTRACTShear induced autoregulation is the natural ability of organs to maintain the local hemodynamic stresses in a stable condition in spite of altering perfusion rate. Endothelium cells are shear sensitive mechanoreceptors that are responsible for regulating the arterial wall architecture and mechanical properties in order to maintain homeostasis. This occurs by means of vasoactive mediators, which cause vasodilation or vasoconstriction. In this paper we presented a multiscale model of local flow regulation. First, a lumped parameter model of the whole cardiovascular system was implemented. Then a 3D numerical model of human common carotid artery was constructed considering fluid-structure interaction. The CCA inflow waveform obtained from the extended 0D model was applied to the 3D model as the boundary condition. After applying the Head-Up Tilt test, the local hemodynamics were disturbed. By considering the wall shear stress as the regulation criterion, then altering the arterial mechanical properties and the following vasodilation, shear forces exerted on the inner lining of the vessel were regulated and returned to the normal range. The resulting 0D/3D model can be considered as a plat-form for a more complete model containing local and systemic cardiovascular control mechanisms and patient-specific geometries which can be used for clinical purposes.

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