Effects of Growth Hormone Replacement Therapy on Bone Markers and Bone Mineral Density in Growth Hormone-Deficient Adults

2000 ◽  
Vol 54 (1) ◽  
pp. 52-57 ◽  
Author(s):  
Anna G. Nilsson
Keyword(s):  
Bone Mineral Density ◽  
Growth Hormone ◽  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Bone Mineral ◽  
Bone Markers ◽  
Hormone Replacement ◽  
Growth Hormone Replacement ◽  
Mineral Density ◽  
Growth Hormone Replacement Therapy

scholarly journals Effects of Growth Hormone Replacement Therapy on Bone Mineral Density in Growth Hormone Deficient Adults: A Meta-Analysis

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Peng Xue ◽  
Yan Wang ◽  
Jie Yang ◽  
Yukun Li
Keyword(s):  
Bone Mineral Density ◽  
Growth Hormone ◽  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Bone Mineral ◽  
Meta Analysis ◽  
Hormone Replacement ◽  
Growth Hormone Replacement ◽  
Mineral Density ◽  
Growth Hormone Replacement Therapy

Objectives. Growth hormone deficiency patients exhibited reduced bone mineral density compared with healthy controls, but previous researches demonstrated uncertainty about the effect of growth hormone replacement therapy on bone in growth hormone deficient adults. The aim of this study was to determine whether the growth hormone replacement therapy could elevate bone mineral density in growth hormone deficient adults.Methods. In this meta-analysis, searches of Medline, Embase, and The Cochrane Library were undertaken to identify studies in humans of the association between growth hormone treatment and bone mineral density in growth hormone deficient adults. Random effects model was used for this meta-analysis.Results. A total of 20 studies (including one outlier study) with 936 subjects were included in our research. We detected significant overall association of growth hormone treatment with increased bone mineral density of spine, femoral neck, and total body, but some results of subgroup analyses were not consistent with the overall analyses.Conclusions. Our meta-analysis suggested that growth hormone replacement therapy could have beneficial influence on bone mineral density in growth hormone deficient adults, but, in some subject populations, the influence was not evident.

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